7W77
cryo-EM structure of human NaV1.3/beta1/beta2-bulleyaconitineA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0001518 | cellular_component | voltage-gated sodium channel complex |
| B | 0006814 | biological_process | sodium ion transport |
| B | 0017080 | molecular_function | sodium channel regulator activity |
| C | 0016020 | cellular_component | membrane |
| D | 0001518 | cellular_component | voltage-gated sodium channel complex |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005248 | molecular_function | voltage-gated sodium channel activity |
| D | 0005261 | molecular_function | monoatomic cation channel activity |
| D | 0005272 | molecular_function | sodium channel activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0006814 | biological_process | sodium ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0016528 | cellular_component | sarcoplasm |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0034702 | cellular_component | monoatomic ion channel complex |
| D | 0035725 | biological_process | sodium ion transmembrane transport |
| D | 0048266 | biological_process | behavioral response to pain |
| D | 0055085 | biological_process | transmembrane transport |
| D | 0086002 | biological_process | cardiac muscle cell action potential involved in contraction |
| D | 0086010 | biological_process | membrane depolarization during action potential |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 867 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| D | MET1-SER128 | |
| D | GLY1465-VAL1527 | |
| D | LYS1576-ILE1587 | |
| D | LYS1636-ALA1654 | |
| D | ARG176-PRO189 | |
| D | PRO231-ASP249 | |
| D | VAL422-PRO760 | |
| D | ILE811-TRP824 | |
| D | TRP865-GLY880 | |
| D | LEU984-TRP1207 | |
| D | LYS1258-ALA1271 | |
| D | PHE1318-SER1334 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S1 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| D | LEU129-LEU147 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 321 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| D | SER148-THR154 | |
| D | ALA1291-GLY1298 | |
| D | ASN1355-VAL1403 | |
| D | ALA1426-LEU1442 | |
| D | GLU1546-LEU1556 | |
| D | LEU1606-THR1618 | |
| D | GLY1673-THR1694 | |
| D | ILE1718-GLY1747 | |
| D | SER208-SER213 | |
| D | MET270-THR368 | |
| D | ARG394-TYR400 | |
| D | GLU780-SER790 | |
| D | GLU845-GLY846 | |
| D | GLY900-ASP928 | |
| D | ASP950-ILE962 | |
| D | GLU1226-THR1238 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S2 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| D | LYS155-ALA175 | |
| C | ARG135 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S3 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| D | TRP190-VAL207 | |
| B | ASN114 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 16 |
| Details | TRANSMEM: Helical; Name=S4 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| D | ALA214-ILE230 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S5 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| D | VAL250-PHE269 | |
| C | ASN74 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 87 |
| Details | INTRAMEM: Pore-forming => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| D | PHE369-LEU393 | |
| D | PHE929-TRP949 | |
| D | GLY1404-ALA1425 | |
| D | PHE1695-PRO1717 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S6 of repeat I => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| D | MET401-ALA421 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S1 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| D | PHE761-MET779 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S2 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| D | VAL791-LYS810 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S3 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| D | ASN825-VAL844 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S4 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| D | LEU847-SER864 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S5 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| D | ALA881-VAL899 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=S6 of repeat II => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| D | VAL963-LEU983 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S1 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| D | PHE1208-PHE1225 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S2 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| D | MET1239-LEU1257 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S3 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| D | TRP1272-ASN1290 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S4 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| D | ALA1299-ARG1317 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=S5 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| D | ILE1335-VAL1354 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=S6 of repeat III => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| D | TYR1443-ILE1464 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S1 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| D | PHE1528-VAL1545 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=S2 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| D | VAL1557-LEU1575 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S3 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| D | GLY1588-PHE1605 |
| site_id | SWS_FT_FI25 |
| Number of Residues | 16 |
| Details | TRANSMEM: Helical; Name=S4 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| D | LEU1619-ILE1635 |
| site_id | SWS_FT_FI26 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=S5 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| D | LEU1655-PHE1672 |
| site_id | SWS_FT_FI27 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=S6 of repeat IV => ECO:0000250|UniProtKB:D0E0C2 |
| Chain | Residue | Details |
| D | ILE1748-ILE1770 |
| site_id | SWS_FT_FI28 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P08104 |
| Chain | Residue | Details |
| D | SER484 | |
| D | SER485 | |
| D | SER486 |
| site_id | SWS_FT_FI29 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKC => ECO:0000250|UniProtKB:Q14524 |
| Chain | Residue | Details |
| D | SER1501 |
| site_id | SWS_FT_FI30 |
| Number of Residues | 8 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| D | ASN211 | |
| D | ASN290 | |
| D | ASN296 | |
| D | ASN302 | |
| D | ASN307 | |
| D | ASN339 | |
| D | ASN1366 | |
| D | ASN1380 |
