4TXY
 
 | | Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase, a prokaryotic cGAS homolog | | 分子名称: | Cyclic AMP-GMP synthase, MAGNESIUM ION | | 著者 | Kranzusch, P.J, Lee, A.S.Y, Wilson, S.C, Solovykh, M.S, Vance, R.E, Berger, J.M, Doudna, J.A. | | 登録日 | 2014-07-07 | | 公開日 | 2014-08-13 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (3.0001 Å) | | 主引用文献 | Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity.
Cell, 158, 2014
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3EHI
 | | Crystal Structure of Human Thymidyalte Synthase M190K with Loop 181-197 stabilized in the inactive conformation | | 分子名称: | 1,2-ETHANEDIOL, SULFATE ION, Thymidylate synthase | | 著者 | Lovelace, L.L, Gibson, L.M, Johnson, S.R, Berger, S.H, Lebioda, L. | | 登録日 | 2008-09-12 | | 公開日 | 2009-08-18 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Variants of human thymidylate synthase with loop 181-197 stabilized in the inactive conformation.
Protein Sci., 18, 2009
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4RVQ
 | | PWI-like domain of Chaetomium thermophilum Brr2 | | 分子名称: | 1,2-ETHANEDIOL, Pre-mRNA splicing helicase-like protein, SULFATE ION | | 著者 | Absmeier, E, Rosenberger, L, Santos, K.F, Becke, C, Wahl, M.C. | | 登録日 | 2014-11-27 | | 公開日 | 2015-04-01 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.135 Å) | | 主引用文献 | A noncanonical PWI domain in the N-terminal helicase-associated region of the spliceosomal Brr2 protein.
Acta Crystallogr.,Sect.D, 71, 2015
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4KCD
 | | Crystal Structure of the NMDA Receptor GluN3A Ligand Binding Domain Apo State | | 分子名称: | GLYCEROL, Glutamate receptor ionotropic, NMDA 3A | | 著者 | Yao, Y, Lau, A.Y, Mayer, M.L. | | 登録日 | 2013-04-24 | | 公開日 | 2013-07-31 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | | 主引用文献 | Conformational Analysis of NMDA Receptor GluN1, GluN2, and GluN3 Ligand-Binding Domains Reveals Subtype-Specific Characteristics.
Structure, 21, 2013
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4TW9
 | | Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1delta and epsilon with nanomolar inhibitory activity on cancer cell proliferation | | 分子名称: | CHLORIDE ION, Casein kinase I isoform delta, N-(2,2-difluoro-5H-[1,3]dioxolo[4,5-f]benzimidazol-6-yl)-2-{[2-(trifluoromethoxy)benzoyl]amino}-1,3-thiazole-4-carboxamide, ... | | 著者 | Richter, J, Bischof, J, Zaja, M, Kohlhof, H, Othersen, O, Vitt, D, Alscher, V, Pospiech, I, Garcia-Reyes, B, Berg, S, Leban, J, Knippschild, U. | | 登録日 | 2014-06-30 | | 公開日 | 2014-07-30 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Difluoro-dioxolo-benzoimidazol-benzamides As Potent Inhibitors of CK1 delta and epsilon with Nanomolar Inhibitory Activity on Cancer Cell Proliferation.
J.Med.Chem., 57, 2014
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4TYV
 | | Ensemble refinement of the E502A variant of sacteLam55A from Streptomyces sp. SirexAA-E in complex with glucose | | 分子名称: | 1,2-ETHANEDIOL, Putative secreted protein, beta-D-glucopyranose | | 著者 | Bianchetti, C.M, Takasuka, T.E, Yik, E.J, Bergeman, L.F, Fox, B.G. | | 登録日 | 2014-07-09 | | 公開日 | 2015-03-18 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Active site and laminarin binding in glycoside hydrolase family 55.
J.Biol.Chem., 290, 2015
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4TUU
 | | Isolated p110a subunit of PI3Ka provides a platform for structure-based drug design | | 分子名称: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | | 著者 | Chen, P, Deng, Y.-L, Bergqvist, S, Falk, M, Liu, W, Timofeevski, S. | | 登録日 | 2014-06-24 | | 公開日 | 2014-08-06 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | | 主引用文献 | Engineering of an isolated p110 alpha subunit of PI3K alpha permits crystallization and provides a platform for structure-based drug design.
Protein Sci., 23, 2014
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3DOW
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6U5R
 | | Calcium-bound MthK closed state | | 分子名称: | CALCIUM ION, Calcium-gated potassium channel MthK | | 著者 | Fan, C, Nimigean, C.M. | | 登録日 | 2019-08-28 | | 公開日 | 2020-03-25 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Ball-and-chain inactivation in a calcium-gated potassium channel.
Nature, 580, 2020
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7MJ9
 | | HLA-A*02:01 bound to Neuroblastoma Derived mutant IGFBPL1 peptide | | 分子名称: | Beta-2-microglobulin, Insulin-like growth factor-binding protein-like 1 altered peptide, MHC class I antigen | | 著者 | Toor, J.S, Tripathi, S.M, Truong, H.V, Yarmarkovich, M, Maris, J.M, Sgourakis, N.G. | | 登録日 | 2021-04-19 | | 公開日 | 2021-08-18 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs.
Nature, 599, 2021
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7MJ6
 | | HLA-A*02:01 bound to Neuroblastoma Derived IGFBPL1 peptide | | 分子名称: | Beta-2-microglobulin, GLYCEROL, Insulin-like growth factor-binding protein-like 1 peptide, ... | | 著者 | Toor, J.S, Tripathi, S.M, Truong, H.V, Yarmarkovich, M, Maris, J.M, Sgourakis, N.G. | | 登録日 | 2021-04-19 | | 公開日 | 2021-08-18 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs.
Nature, 599, 2021
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7MJ7
 | | HLA-A*02:01 bound to Neuroblastoma Derived IGFBPL1 peptide | | 分子名称: | Beta-2-microglobulin, GLYCEROL, Insulin-like growth factor-binding protein-like 1 peptide, ... | | 著者 | Toor, J.S, Tripathi, S.M, Truong, H.V, Yarmarkovich, M, Maris, J.M, Sgourakis, N.G. | | 登録日 | 2021-04-19 | | 公開日 | 2021-08-18 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs.
Nature, 599, 2021
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7MJA
 | | HLA-A*24:02 bound to Neuroblastoma derived PHOX2B peptide | | 分子名称: | Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ... | | 著者 | Toor, J.S, Tripathi, S.M, Truong, H.V, Yarmarkovich, M, Maris, J.M, Sgourakis, N.G. | | 登録日 | 2021-04-19 | | 公開日 | 2021-08-18 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs.
Nature, 599, 2021
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7MJ8
 | | HLA-A*02:01 bound to Neuroblastoma Derived IGFBPL1 peptide | | 分子名称: | Beta-2-microglobulin, GLYCEROL, Insulin-like growth factor-binding protein-like 1 peptide, ... | | 著者 | Toor, J.S, Tripathi, S.M, Truong, H.V, Yarmarkovich, M, Maris, J.M, Sgourakis, N.G. | | 登録日 | 2021-04-19 | | 公開日 | 2021-08-18 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs.
Nature, 599, 2021
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4TNE
 | | Crystal Structure of Human Transthyretin Thr119Tyr Mutant | | 分子名称: | GLYCEROL, Transthyretin | | 著者 | Saelices, L, Cascio, D, Sawaya, M, Eisenberg, D.S. | | 登録日 | 2014-06-03 | | 公開日 | 2015-10-21 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Uncovering the Mechanism of Aggregation of Human Transthyretin.
J.Biol.Chem., 290, 2015
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4TPJ
 | | Selectivity mechanism of a bacterial homologue of the human drug peptide transporters PepT1 and PepT2 | | 分子名称: | ALA-ALA-ALA, DODECYL-BETA-D-MALTOSIDE, Proton:oligopeptide symporter POT family, ... | | 著者 | Guettou, F, Quistgaard, E, Raba, M, Moberg, P, Low, C, Nordlund, P. | | 登録日 | 2014-06-07 | | 公開日 | 2014-07-09 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3.201 Å) | | 主引用文献 | Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2.
Nat.Struct.Mol.Biol., 21, 2014
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4TQG
 | | Crystal structure of Megavirus UDP-GlcNAc 4,6-dehydratase, 5-epimerase Mg534 | | 分子名称: | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Putative dTDP-d-glucose 4 6-dehydratase | | 著者 | Jeudy, S, Piacente, F, De Castro, C, Molinaro, A, Salis, A, Damonte, G, Bernardi, C, Tonetti, M, Claverie, J.M, Abergel, C. | | 登録日 | 2014-06-11 | | 公開日 | 2014-06-25 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Giant Virus Megavirus chilensis Encodes the Biosynthetic Pathway for Uncommon Acetamido Sugars.
J.Biol.Chem., 289, 2014
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6U5P
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4TVK
 | | TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH A CHLOROTACRINE-JUGLONE HYBRID INHIBITOR | | 分子名称: | 2-({2-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]ethyl}amino)-5-hydroxynaphthalene-1,4-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Pesaresi, A, Samez, S, Lamba, D. | | 登録日 | 2014-06-27 | | 公開日 | 2014-10-08 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Multitarget Drug Design Strategy: Quinone-Tacrine Hybrids Designed To Block Amyloid-beta Aggregation and To Exert Anticholinesterase and Antioxidant Effects.
J.Med.Chem., 57, 2014
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3HAQ
 | | Crystal structure of bacteriorhodopsin mutant I148A crystallized from bicelles | | 分子名称: | 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Bacteriorhodopsin, DECANE, ... | | 著者 | Joh, N.H, Yang, D, Bowie, J.U. | | 登録日 | 2009-05-02 | | 公開日 | 2009-09-22 | | 最終更新日 | 2021-10-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Similar energetic contributions of packing in the core of membrane and water-soluble proteins.
J.Am.Chem.Soc., 131, 2009
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5FH5
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7MRW
 | | Native RhopH complex of the malaria parasite Plasmodium falciparum | | 分子名称: | Cytoadherence linked asexual protein 3.1, High molecular weight rhoptry protein 2, High molecular weight rhoptry protein 3 | | 著者 | Ho, C.M, Jih, J, Lai, M, Li, X.R, Goldberg, D.E, Beck, J.R, Zhou, Z.H. | | 登録日 | 2021-05-10 | | 公開日 | 2021-09-15 | | 実験手法 | ELECTRON MICROSCOPY (3.72 Å) | | 主引用文献 | Native structure of the RhopH complex, a key determinant of malaria parasite nutrient acquisition.
Proc.Natl.Acad.Sci.USA, 118, 2021
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4TLS
 | | Crystal Structure of Human Transthyretin Glu92Pro Mutant | | 分子名称: | GLYCEROL, PHOSPHATE ION, SODIUM ION, ... | | 著者 | Saelices, L, Cascio, D, Sawaya, M, Eisenberg, D.S. | | 登録日 | 2014-05-30 | | 公開日 | 2015-10-21 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Uncovering the Mechanism of Aggregation of Human Transthyretin.
J.Biol.Chem., 290, 2015
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3HAN
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4RRN
 | | 8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors | | 分子名称: | (4S,4a'S,10a'R)-2-amino-8'-(2-fluoropyridin-3-yl)-1-methyl-3',4',4a',10a'-tetrahydro-2'H-spiro[imidazole-4,10'-pyrano[3,2-b]chromen]-5(1H)-one, Beta-secretase 1, NICKEL (II) ION | | 著者 | Thomas, A.A, Hunt, K.W, Newhouse, B, Watts, R.J, Liu, X, Vigers, G.P.A, Smith, D, Rhodes, S.P, Brown, K.D, Otten, J.N, Burkard, M, Cox, A.A, Geck Do, M.K, Dutcher, D, Rana, S, DeLisle, R.K, Regal, K, Wright, A.D, Groneberg, R, Liao, J, Scearce-Levie, K, Siu, M, Purkey, H.E, Lyssikatos, J.P. | | 登録日 | 2014-11-06 | | 公開日 | 2014-12-03 | | 最終更新日 | 2014-12-31 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | 8-Tetrahydropyran-2-yl Chromans: Highly Selective Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors.
J.Med.Chem., 57, 2014
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