4TUU

Isolated p110a subunit of PI3Ka provides a platform for structure-based drug design

Summary for 4TUU

Related4TV3
DescriptorPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (2 entities in total)
Functional Keywordslipid kinase activity, atpase activity, surface plasmon resonance (spr), isothermal titration calorimetry (itc)., transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight109983.09
Authors
Chen, P.,Deng, Y.-L.,Bergqvist, S.,Falk, M.,Liu, W.,Timofeevski, S. (deposition date: 2014-06-24, release date: 2014-08-06, Last modification date: 2015-02-04)
Primary citation
Chen, P.,Deng, Y.L.,Bergqvist, S.,Falk, M.D.,Liu, W.,Timofeevski, S.,Brooun, A.
Engineering of an isolated p110 alpha subunit of PI3K alpha permits crystallization and provides a platform for structure-based drug design.
Protein Sci., 23:1332-1340, 2014
PubMed: 25043846 (PDB entries with the same primary citation)
DOI: 10.1002/pro.2517
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.64 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.26321.4%4.5%7.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
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PDB entries from 2020-07-29