4TW9

Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1delta and epsilon with nanomolar inhibitory activity on cancer cell proliferation

Summary for 4TW9

Entry DOI	10.2210/pdb4tw9/pdb
Descriptor	Casein kinase I isoform delta, SULFATE ION, octyl beta-L-talopyranoside, ... (7 entities in total)
Functional Keywords	transferase, ck1delta, ck1epsilon, phosphorylation, small molecule inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	71192.10
Authors	Richter, J.,Bischof, J.,Zaja, M.,Kohlhof, H.,Othersen, O.,Vitt, D.,Alscher, V.,Pospiech, I.,Garcia-Reyes, B.,Berg, S.,Leban, J.,Knippschild, U. (deposition date: 2014-06-30, release date: 2014-07-30, Last modification date: 2024-05-08)
Primary citation	Richter, J.,Bischof, J.,Zaja, M.,Kohlhof, H.,Othersen, O.,Vitt, D.,Alscher, V.,Pospiech, I.,Garcia-Reyes, B.,Berg, S.,Leban, J.,Knippschild, U. Difluoro-dioxolo-benzoimidazol-benzamides As Potent Inhibitors of CK1 delta and epsilon with Nanomolar Inhibitory Activity on Cancer Cell Proliferation. J.Med.Chem., 57:7933-7946, 2014 Cited by PubMed: 25191940 DOI: 10.1021/jm500600b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation