8SB0
 
 | | CryoEM structure of DH270.I4.6-CH848.10.17 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CH848.10.17.SOSIP gp120, CH848.10.17.SOSIP gp41, ... | | 著者 | Henderson, R, Zhou, Y, Stalls, V, Bartesaghi, B, Acharya, P. | | 登録日 | 2023-04-02 | | 公開日 | 2023-04-19 | | 最終更新日 | 2023-05-31 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Structural basis for breadth development in the HIV-1 V3-glycan targeting DH270 antibody clonal lineage.
Nat Commun, 14, 2023
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8SB1
 | | CryoEM structure of DH270.I3-CH848.10.17 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CH848.10.17 gp120, CH848.10.17.SOSIP gp41, ... | | 著者 | Henderson, R, Zhou, Y, Stalls, V, Bartesaghi, B, Acharya, P. | | 登録日 | 2023-04-02 | | 公開日 | 2023-04-19 | | 最終更新日 | 2023-05-31 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Structural basis for breadth development in the HIV-1 V3-glycan targeting DH270 antibody clonal lineage.
Nat Commun, 14, 2023
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8SB2
 | | CryoEM structure of DH270.I2-CH848.10.17 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CH848.10.17.SOSIP gp120, CH848.10.17.SOSIP gp41, ... | | 著者 | Henderson, R, Zhou, Y, Stalls, V, Bartesaghi, B, Acharya, P. | | 登録日 | 2023-04-02 | | 公開日 | 2023-04-19 | | 最終更新日 | 2023-05-31 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural basis for breadth development in the HIV-1 V3-glycan targeting DH270 antibody clonal lineage.
Nat Commun, 14, 2023
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8SB4
 | | CryoEM structure of DH270.1-CH848.10.17 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CH848.10.17 gp120, CH848.10.17 gp41, ... | | 著者 | Henderson, R, Zhou, Y, Stalls, V, Bartesaghi, B, Acharya, P. | | 登録日 | 2023-04-02 | | 公開日 | 2023-04-19 | | 最終更新日 | 2023-05-31 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural basis for breadth development in the HIV-1 V3-glycan targeting DH270 antibody clonal lineage.
Nat Commun, 14, 2023
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8SD2
 | | Crystal structure of the A/Puerto Rico/8/1934 (H1N1) influenza virus hemagglutinin in complex with small molecule fusion inhibitor compound 4 | | 分子名称: | (S~6~S)-N-{3-chloro-4-[(2S)-2-phenylmorpholine-4-carbonyl]phenyl}-5,7-dihydro-6H-pyrrolo[3,4-b]pyridine-6-sulfonimidoyl fluoride, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Kadam, R.U, Zhu, X.Y, Wilson, I.A. | | 登録日 | 2023-04-06 | | 公開日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | Ultrapotent influenza hemagglutinin fusion inhibitors developed through SuFEx-enabled high-throughput medicinal chemistry.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8SD4
 | | Crystal structure of the A/Puerto Rico/8/1934 (H1N1) influenza virus hemagglutinin in complex with small molecule fusion inhibitor compound 7 | | 分子名称: | (S~1~S)-N-{3,5-dichloro-4-[(2S)-2-phenylmorpholine-4-carbonyl]phenyl}-3-[(dimethylamino)methyl]azetidine-1-sulfonimidoyl fluoride, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, ... | | 著者 | Kadam, R.U, Zhu, X, Wilson, I.A. | | 登録日 | 2023-04-06 | | 公開日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (3.11 Å) | | 主引用文献 | Ultrapotent influenza hemagglutinin fusion inhibitors developed through SuFEx-enabled high-throughput medicinal chemistry.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8SDH
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8SGM
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8SGO
 | | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus pregnenolone sulfate | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ... | | 著者 | Legesse, D.H, Fan, C, Teng, J, Zhuang, Y, Howard, R.J, Noviello, C.M, Lindahl, E, Hibbs, R.E. | | 登録日 | 2023-04-12 | | 公開日 | 2023-08-30 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.65 Å) | | 主引用文献 | Structural insights into opposing actions of neurosteroids on GABA A receptors.
Nat Commun, 14, 2023
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8SI9
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8SID
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8SJ9
 | | Crystal structure of the H1 hemagglutinin COBRA X6 | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Dzimianski, J.V, DuBois, R.M. | | 登録日 | 2023-04-17 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | | 主引用文献 | Structural basis for the broad antigenicity of the computationally optimized influenza hemagglutinin X6.
Structure, 2024
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8SK7
 | | Cryo-EM structure of designed Influenza HA binder, HA_20, bound to Influenza HA (Strain: Iowa43) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HA_20 minibinder (RFdiffusion-designed), ... | | 著者 | Borst, A.J, Bennett, N.R. | | 登録日 | 2023-04-18 | | 公開日 | 2023-06-14 | | 最終更新日 | 2023-09-13 | | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | | 主引用文献 | De novo design of protein structure and function with RFdiffusion.
Nature, 620, 2023
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8SKU
 | | Structure of human SIgA1 in complex with human CD89 (FcaR1) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin J chain, ... | | 著者 | Liu, Q, Stadtmueller, B.M. | | 登録日 | 2023-04-20 | | 公開日 | 2023-10-25 | | 最終更新日 | 2023-11-08 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | SIgA structures bound to Streptococcus pyogenes M4 and human CD89 provide insights into host-pathogen interactions.
Nat Commun, 14, 2023
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8SKV
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8SL1
 | | Cryo-EM structure of PAPP-A2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Judge, R.A, Stoll, V.S, Eaton, D, Hao, Q, Bratkowski, M.A. | | 登録日 | 2023-04-20 | | 公開日 | 2023-11-08 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.13 Å) | | 主引用文献 | Cryo-EM structure of human PAPP-A2 and mechanism of substrate recognition.
Commun Chem, 6, 2023
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8SMI
 | | Crystal structure of antibody WRAIR-2123 in complex with SARS-CoV-2 receptor binding domain | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, WRAIR-2123 Fab heavy chain, ... | | 著者 | Sankhala, R.S, Jensen, J.L, Joyce, M.G. | | 登録日 | 2023-04-26 | | 公開日 | 2023-12-13 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Antibody targeting of conserved sites of vulnerability on the SARS-CoV-2 spike receptor-binding domain.
Structure, 32, 2024
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8SNP
 | | Crystal structure of mouse Netrin-1 in complex with samarium ions | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Heide, F, Legare, S, Stetefeld, J. | | 登録日 | 2023-04-27 | | 公開日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Investigating the structural and functional roles of calcium binding in Netrin-1
To Be Published
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8SPH
 | | Crystal structure of chimeric omicron RBD (strain XBB.1) complexed with human ACE2 | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhang, W, Shi, K, Aihara, H, Li, F. | | 登録日 | 2023-05-03 | | 公開日 | 2023-08-02 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | | 主引用文献 | Structural evolution of SARS-CoV-2 omicron in human receptor recognition.
J.Virol., 97, 2023
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8SPI
 | | Crystal structure of chimeric omicron RBD (strain XBB.1.5) complexed with human ACE2 | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhang, W, Shi, K, Aihara, H, Li, F. | | 登録日 | 2023-05-03 | | 公開日 | 2023-08-02 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3.06 Å) | | 主引用文献 | Structural evolution of SARS-CoV-2 omicron in human receptor recognition.
J.Virol., 97, 2023
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8SUF
 | | The complex of TOL-1 ectodomain bound to LAT-1 Lectin domain | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Latrophilin-like protein 1, ... | | 著者 | Carmona Rosas, G, Li, J, Arac, D, Ozkan, E. | | 登録日 | 2023-05-12 | | 公開日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (4 Å) | | 主引用文献 | Structural basis and functional roles for Toll-like receptor binding to Latrophilin adhesion-GPCR in embryo development
To Be Published
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8SUR
 | | TMEM16F bound with Niclosamide | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide, ... | | 著者 | Feng, S, Cheng, Y. | | 登録日 | 2023-05-13 | | 公開日 | 2023-09-06 | | 最終更新日 | 2023-11-01 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase.
Nat Commun, 14, 2023
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8SW4
 | | BG505 GT1.1 SOSIP in complex with NHP Fabs 21N13, 21M20 and RM20A3 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 21M20 heavy chain variable region, ... | | 著者 | Ozorowski, G, Torres, J.L, Zhang, S, Ward, A.B. | | 登録日 | 2023-05-17 | | 公開日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | | 主引用文献 | Neutralizing antibodies induced in non-human primates by germline targeting Env trimer
To Be Published
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8SWV
 | | BG505 Boost2 SOSIP.664 in complex with NHP polyclonal antibody IF1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IF1 Heavy Chain, ... | | 著者 | Pratap, P.P, Antansijevic, A, Ozorowski, G, Ward, A.B. | | 登録日 | 2023-05-19 | | 公開日 | 2024-05-22 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | | 主引用文献 | Priming antibody responses to the fusion peptide in rhesus macaques.
Npj Vaccines, 9, 2024
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8SWW
 | | BG505 Boost2 SOSIP.664 in complex with NHP polyclonal antibody IF3 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, NHP polyclonal antibody IF3 Heavy Chain, ... | | 著者 | Pratap, P.P, Antansijevic, A, Ward, A.B. | | 登録日 | 2023-05-19 | | 公開日 | 2024-05-22 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Priming antibody responses to the fusion peptide in rhesus macaques.
Npj Vaccines, 9, 2024
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