8SK7

Cryo-EM structure of designed Influenza HA binder, HA_20, bound to Influenza HA (Strain: Iowa43)

Summary for 8SK7

Entry DOI	10.2210/pdb8sk7/pdb
EMDB information	40557
Descriptor	Hemagglutinin HA1 chain, Hemagglutinin, HA_20 minibinder (RFdiffusion-designed), ... (6 entities in total)
Functional Keywords	flu, influenza, hemagglutinin, ha, iowa43, ha_20, de novo protein, minibinder, binder, designed protein, fusion protein, glycoprotein, de novo protein-viral protein complex, de novo protein/viral protein
Biological source	Influenza A virus More
Total number of polymer chains	9
Total formula weight	215503.28
Authors	Borst, A.J.,Bennett, N.R. (deposition date: 2023-04-18, release date: 2023-06-14, Last modification date: 2023-09-13)
Primary citation	Watson, J.L.,Juergens, D.,Bennett, N.R.,Trippe, B.L.,Yim, J.,Eisenach, H.E.,Ahern, W.,Borst, A.J.,Ragotte, R.J.,Milles, L.F.,Wicky, B.I.M.,Hanikel, N.,Pellock, S.J.,Courbet, A.,Sheffler, W.,Wang, J.,Venkatesh, P.,Sappington, I.,Torres, S.V.,Lauko, A.,De Bortoli, V.,Mathieu, E.,Ovchinnikov, S.,Barzilay, R.,Jaakkola, T.S.,DiMaio, F.,Baek, M.,Baker, D. De novo design of protein structure and function with RFdiffusion. Nature, 620:1089-1100, 2023 Cited by PubMed: 37433327 DOI: 10.1038/s41586-023-06415-8 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.93 Å)

Structure validation