PDB: 2596 件ウェブページステータス検索Chemie searchBIRD

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5X9O	Crystal structure of the BCL6 BTB domain in complex with Compound 1a 分子名称: 1,2-ETHANEDIOL, 5-[(2-chloranyl-4-nitro-phenyl)amino]-1,3-dihydrobenzimidazol-2-one, B-cell lymphoma 6 protein, ... 著者 Sogabe, S, Ida, K, Lane, W, Snell, G. 登録日 2017-03-08 公開日 2017-08-16 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design Bioorg. Med. Chem., 25, 2017
8JU9	Molecular mechanism of the one-component regulator RccR on bacterial metabolism and virulence 分子名称: 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, 2-KETO-DEOXY-GALACTOSE, DI(HYDROXYETHYL)ETHER, ... 著者 Rui, B, Yibo, Z. 登録日 2023-06-25 公開日 2024-01-17 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Molecular mechanism of the one-component regulator RccR on bacterial metabolism and virulence. Nucleic Acids Res., 52, 2024
5X9P	Crystal structure of the BCL6 BTB domain in complex with Compound 5 分子名称: 3-[[4-chloranyl-2-nitro-5-[(2-oxidanylidene-1,3-dihydrobenzimidazol-5-yl)amino]phenyl]amino]propanoic acid, B-cell lymphoma 6 protein 著者 Sogabe, S, Ida, K, Lane, W, Snell, G. 登録日 2017-03-08 公開日 2017-08-16 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design Bioorg. Med. Chem., 25, 2017
4L9J	Crystal structure of S. aureus MepR in DNA-binding conformation 分子名称: MepR 著者 Birukou, I, Brennan, R.G. 登録日 2013-06-18 公開日 2013-09-11 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (3.45 Å) 主引用文献 The molecular mechanisms of allosteric mutations impairing MepR repressor function in multidrug-resistant strains of Staphylococcus aureus. MBio, 4, 2013
4L9V	Crystal structure of Se-Met derivative MepR F27L mutant from multidrug resistant S. aureus clinical isolate 分子名称: MepR 著者 Birukou, I, Brennan, R.G. 登録日 2013-06-18 公開日 2013-09-11 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (2.374 Å) 主引用文献 The molecular mechanisms of allosteric mutations impairing MepR repressor function in multidrug-resistant strains of Staphylococcus aureus. MBio, 4, 2013
1GXR	WD40 Region of Human Groucho/TLE1 分子名称: CALCIUM ION, TRANSDUCIN-LIKE ENHANCER PROTEIN 1 著者 Pearl, L.H, Roe, S.M, Pickles, L.M. 登録日 2002-04-10 公開日 2002-06-13 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Crystal Structure of the C-Terminal Wd40 Repeat Domain of the Human Groucho/Tle1 Transcriptional Corepressor Structure, 10, 2002
1MYL	SUBSTITUTING HYDROPHOBIC RESIDUES FOR A BURIED SALT BRIDGE ENHANCES PROTEIN STABILITY BUT DOES NOT REDUCE CONFORMATIONAL SPECIFICITY 分子名称: ARC REPRESSOR 著者 Schildbach, J.F, Waldburger, C.D, Sauer, R.T. 登録日 1994-10-06 公開日 1995-01-26 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Are buried salt bridges important for protein stability and conformational specificity? Nat.Struct.Biol., 2, 1995
2KC9	Structure of E. coli toxin RelE (R81A/R83A) mutant in the free state 分子名称: Toxin relE 著者 Li, G, Zhang, Y, Inouye, M, Ikura, M. 登録日 2008-12-17 公開日 2009-03-17 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Inhibitory mechanism of Escherichia coli RelE-RelB toxin-antitoxin module involves a helix displacement near an mRNA interferase active site. J.Biol.Chem., 284, 2009
3BR0	Crystal Structure of the Complex of Malachite Green Bound to QacR(E120Q), a Mutant of a Multidrug Binding Transcriptional Repressor 分子名称: HTH-type transcriptional regulator qacR, IMIDAZOLE, MALACHITE GREEN, ... 著者 Brooks, B.E. 登録日 2007-12-20 公開日 2008-12-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Formal electrostatic interactions do not govern QacR-cation affinity To be Published
3BQZ	Crystal Structure of the Complex of Malachite Green Bound to QacR(E90Q), a Mutant of a Multidrug Binding Transcriptional Repressor 分子名称: HTH-type transcriptional regulator qacR, IMIDAZOLE, MALACHITE GREEN, ... 著者 Brooks, B.E. 登録日 2007-12-20 公開日 2008-12-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Formal electrostatic interactions do not govern QacR-cation affinity To be Published
1QTG	AVERAGED NMR MODEL OF SWITCH ARC, A DOUBLE MUTANT OF ARC REPRESSOR 分子名称: Transcriptional repressor arc 著者 Cordes, M.H.J, Walsh, N.P, McKnight, C.J, Sauer, R.T. 登録日 1999-06-27 公開日 1999-07-12 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Evolution of a protein fold in vitro. Science, 284, 1999
1XA7	Crystal structure of the benzylpenicillin-acylated BlaR1 sensor domain from Staphylococcus aureus 分子名称: OPEN FORM - PENICILLIN G, Regulatory protein BlaR1 著者 Wilke, M.S, Hills, T.L, Zhang, H.Z, Chambers, H.F, Strynadka, N.C. 登録日 2004-08-25 公開日 2004-09-21 最終更新日 2018-10-24 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structures of the Apo and penicillin-acylated forms of the BlaR1 beta-lactam sensor of Staphylococcus aureus. J.Biol.Chem., 279, 2004
3DEU	Crystal structure of transcription regulatory protein slyA from Salmonella typhimurium in complex with salicylate ligands 分子名称: 2-HYDROXYBENZOIC ACID, Transcriptional regulator slyA 著者 Le Trong, I, Brzovic, P.S, Fang, F.C, Libby, S.J, Stenkamp, R.E. 登録日 2008-06-10 公開日 2008-06-24 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The Evolution of SlyA/RovA Transcription Factors from Repressors to Countersilencers in Enterobacteriaceae . Mbio, 10, 2019
4IVN	The Vibrio vulnificus NanR protein complexed with ManNAc-6P 分子名称: 2-acetamido-2-deoxy-6-O-phosphono-alpha-D-mannopyranose, Transcriptional regulator 著者 Hwang, J, Kim, M.H. 登録日 2013-01-23 公開日 2013-07-17 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural insights into the regulation of sialic acid catabolism by the Vibrio vulnificus transcriptional repressor NanR Proc.Natl.Acad.Sci.USA, 110, 2013
2MD5	Structure of uninhibited ETV6 ETS domain 分子名称: Transcription factor ETV6 著者 De, S, Mcintosh, L.P, Chan, A.C, Coyne, H.J, Okon, M, Graves, B.J, Murphy, M.E. 登録日 2013-08-29 公開日 2013-12-25 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Steric Mechanism of Auto-Inhibitory Regulation of Specific and Non-Specific DNA Binding by the ETS Transcriptional Repressor ETV6. J.Mol.Biol., 426, 2014
1GMG	ALANINE 31 PROLINE MUTANT OF ROP PROTEIN, MONOCLINIC FORM 分子名称: REGULATORY PROTEIN ROP 著者 Glykos, N.M, Kokkinidis, M. 登録日 2001-09-13 公開日 2002-09-12 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure Determination of a Small Protein Through a 23-Dimensional Molecular-Replacement Search. Acta Crystallogr.,Sect.D, 59, 2003
7RCU	Synthetic Max homodimer mimic in complex with DNA 分子名称: 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, 2-(2,5-dioxopyrrolidin-1-yl)acetamide, ACETAMIDE, ... 著者 Speltz, T, Qiao, Z, Shangguan, S, Fanning, S, Greene, J, Moellering, R. 登録日 2021-07-08 公開日 2022-09-14 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Targeting MYC with modular synthetic transcriptional repressors derived from bHLH DNA-binding domains. Nat.Biotechnol., 41, 2023
2Z4J	Crystal structure of AR LBD with SHP peptide NR Box 2 分子名称: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, Nuclear receptor 0B2 著者 Jouravel, N, Fletterick, R.J. 登録日 2007-06-19 公開日 2007-12-04 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Interaction between the androgen receptor and a segment of its corepressor SHP Acta Crystallogr.,Sect.D, 63, 2007
3BPX	Crystal Structure of MarR 分子名称: 2-HYDROXYBENZOIC ACID, SODIUM ION, Transcriptional regulator 著者 Saridakis, V, Shahinas, D, Xu, X, Christendat, D. 登録日 2007-12-19 公開日 2008-05-20 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural insight on the mechanism of regulation of the MarR family of proteins: high-resolution crystal structure of a transcriptional repressor from Methanobacterium thermoautotrophicum. J.Mol.Biol., 377, 2008
4LLL	Crystal structure of S. aureus MepR-DNA complex 分子名称: MepR, Palindromized mepR operator sequence 著者 Birukou, I, Brennan, R.G. 登録日 2013-07-09 公開日 2014-05-14 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.036 Å) 主引用文献 Structural mechanism of transcription regulation of the Staphylococcus aureus multidrug efflux operon mepRA by the MarR family repressor MepR. Nucleic Acids Res., 42, 2014
4LLN	Crystal structure of S. aureus MepR-DNA complex 分子名称: MepR, Palindromized mepR operator sequence 著者 Birukou, I, Brennan, R.G. 登録日 2013-07-09 公開日 2014-05-14 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.842 Å) 主引用文献 Structural mechanism of transcription regulation of the Staphylococcus aureus multidrug efflux operon mepRA by the MarR family repressor MepR. Nucleic Acids Res., 42, 2014
4HQM	The crystal structure of QsrR-menadione complex 分子名称: 2-methylnaphthalene-1,4-diol, QsrR protein 著者 Ji, Q, Zhang, L, Jones, M.B, Sun, F, Deng, X, Liang, H, Brugarolas, P, Gao, N, Peterson, S.N, Lan, L, Bae, T, He, C. 登録日 2012-10-25 公開日 2013-03-06 最終更新日 2013-05-22 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR. Proc.Natl.Acad.Sci.USA, 110, 2013
4HQE	The crystal structure of QsrR-DNA complex 分子名称: DNA (5'-D(*AP*GP*TP*AP*TP*AP*AP*TP*TP*AP*TP*TP*AP*TP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*AP*TP*AP*AP*TP*AP*AP*TP*TP*AP*TP*AP*CP*T)-3'), Transcriptional regulator QsrR 著者 He, C, Ji, Q, Zhang, L. 登録日 2012-10-25 公開日 2013-03-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.299 Å) 主引用文献 Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR. Proc.Natl.Acad.Sci.USA, 110, 2013
1QX8	Crystal structure of a five-residue deletion mutant of the Rop protein 分子名称: Regulatory protein ROP 著者 Glykos, N.M, Vlassi, M, Papanikolaou, Y, Kotsifaki, D, Cesareni, G, Kokkinidis, M. 登録日 2003-09-04 公開日 2004-09-28 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Loopless Rop: structure and dynamics of an engineered homotetrameric variant of the repressor of primer protein. Biochemistry, 45, 2006
6AZ6	Streptococcus agalactiae GntR 分子名称: GntR family transcriptional regulator 著者 Pellock, S.J, Redinbo, M.R. 登録日 2017-09-10 公開日 2017-12-20 最終更新日 2019-12-04 実験手法 X-RAY DIFFRACTION (1.909 Å) 主引用文献 Structural basis for the regulation of beta-glucuronidase expression by human gut Enterobacteriaceae. Proc. Natl. Acad. Sci. U.S.A., 115, 2018

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