7A0S
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![BU of 7a0s by Molmil](/molmil-images/mine/7a0s) | 50S Deinococcus radiodurans ribosome bounded with mycinamicin I | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | 著者 | Breiner, E, Eyal, Z, Matzov, D, Halfon, Y, Cimicata, G, Rozenberg, H, Zimmerman, E, Bashan, A, Yonath, A. | 登録日 | 2020-08-10 | 公開日 | 2021-08-18 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.22 Å) | 主引用文献 | Ribosome-binding and anti-microbial studies of the mycinamicins, 16-membered macrolide antibiotics from Micromonospora griseorubida. Nucleic Acids Res., 49, 2021
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8ER6
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![BU of 8er6 by Molmil](/molmil-images/mine/8er6) | FKBP12-FRB in Complex with Compound 11 | 分子名称: | (3S,5R,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30R,34aS)-5,9,27-trihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-5,6,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-octadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,11,28,29(4H,31H)-tetrone, 1,2-ETHANEDIOL, Peptidyl-prolyl cis-trans isomerase FKBP1A, ... | 著者 | Tomlinson, A.C.A, Yano, J.K. | 登録日 | 2022-10-11 | 公開日 | 2022-12-28 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors. J.Med.Chem., 66, 2023
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8ER7
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![BU of 8er7 by Molmil](/molmil-images/mine/8er7) | FKBP12-FRB in Complex with Compound 12 | 分子名称: | (3S,5R,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-5,10,21-trimethoxy-6,8,12,14,20,26-hexamethyl-5,6,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-octadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,11,28,29(4H,31H)-tetrone, CHLORIDE ION, Peptidyl-prolyl cis-trans isomerase FKBP1A, ... | 著者 | Tomlinson, A.C.A, Yano, J.K. | 登録日 | 2022-10-11 | 公開日 | 2022-12-28 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.07 Å) | 主引用文献 | Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors. J.Med.Chem., 66, 2023
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8Q1S
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![BU of 8q1s by Molmil](/molmil-images/mine/8q1s) | Pathogenic mutations of human phosphorylation sites affect protein-protein interactions | 分子名称: | 1,2-ETHANEDIOL, 14-3-3 protein epsilon, BROMIDE ION, ... | 著者 | Roske, Y, Daumke, O, Rrustemi, T, Selbach, M. | 登録日 | 2023-08-01 | 公開日 | 2024-02-21 | 最終更新日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (3.23 Å) | 主引用文献 | Pathogenic mutations of human phosphorylation sites affect protein-protein interactions. Nat Commun, 15, 2024
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1M0L
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![BU of 1m0l by Molmil](/molmil-images/mine/1m0l) | BACTERIORHODOPSIN/LIPID COMPLEX AT 1.47 A RESOLUTION | 分子名称: | 1-[2,6,10.14-TETRAMETHYL-HEXADECAN-16-YL]-2-[2,10,14-TRIMETHYLHEXADECAN-16-YL]GLYCEROL, 2,10,23-TRIMETHYL-TETRACOSANE, BACTERIORHODOPSIN, ... | 著者 | Lanyi, J.K. | 登録日 | 2002-06-13 | 公開日 | 2002-09-11 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Crystallographic structure of the K intermediate of bacteriorhodopsin: conservation of free energy after photoisomerization of the retinal. J.Mol.Biol., 321, 2002
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5UJA
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![BU of 5uja by Molmil](/molmil-images/mine/5uja) | Cryo-EM structure of bovine multidrug resistance protein 1 (MRP1) bound to leukotriene C4 | 分子名称: | (5~{S},6~{R},7~{E},9~{E},11~{Z},14~{Z})-6-[(2~{R})-2-[[(4~{S})-4-azanyl-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]-3-( 2-hydroxy-2-oxoethylamino)-3-oxidanylidene-propyl]sulfanyl-5-oxidanyl-icosa-7,9,11,14-tetraenoic acid, bovine multidrug resistance protein 1 (MRP1),Multidrug resistance-associated protein 1 | 著者 | Johnson, Z.L, Chen, J. | 登録日 | 2017-01-17 | 公開日 | 2017-02-22 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | 主引用文献 | Structural Basis of Substrate Recognition by the Multidrug Resistance Protein MRP1. Cell, 168, 2017
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5M0M
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![BU of 5m0m by Molmil](/molmil-images/mine/5m0m) | Structure-based evolution of a hybrid steroid series of Autotaxin inhibitors | 分子名称: | (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate, CALCIUM ION, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, ... | 著者 | Keune, W.-J, Heidebrecht, T, Perrakis, A. | 登録日 | 2016-10-05 | 公開日 | 2017-08-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Rational Design of Autotaxin Inhibitors by Structural Evolution of Endogenous Modulators. J. Med. Chem., 60, 2017
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5M0S
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![BU of 5m0s by Molmil](/molmil-images/mine/5m0s) | Structure-based evolution of a hybrid steroid series of Autotaxin inhibitors | 分子名称: | CALCIUM ION, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, GLYCEROL, ... | 著者 | Keune, W.-J, Heidebrecht, T, Perrakis, A. | 登録日 | 2016-10-05 | 公開日 | 2017-08-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Rational Design of Autotaxin Inhibitors by Structural Evolution of Endogenous Modulators. J. Med. Chem., 60, 2017
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1U65
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![BU of 1u65 by Molmil](/molmil-images/mine/1u65) | Ache W. CPT-11 | 分子名称: | (4S)-4,11-DIETHYL-4-HYDROXY-3,14-DIOXO-3,4,12,14-TETRAHYDRO-1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLIN-9-YL 1,4'-BIPIPERIDINE-1'-CARBOXYLATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholinesterase, ... | 著者 | Harel, M, Hyatt, J.L, Brumshtein, B, Morton, C.L, Wadkins, R.W, Silman, I, Sussman, J.L, Potter, P.M, Israel Structural Proteomics Center (ISPC) | 登録日 | 2004-07-29 | 公開日 | 2005-07-19 | 最終更新日 | 2021-06-02 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action Mol.Pharmacol., 67, 2005
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7KF1
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![BU of 7kf1 by Molmil](/molmil-images/mine/7kf1) | |
1C8R
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![BU of 1c8r by Molmil](/molmil-images/mine/1c8r) | BACTERIORHODOPSIN D96N BR STATE AT 2.0 A RESOLUTION | 分子名称: | 1-[2,6,10.14-TETRAMETHYL-HEXADECAN-16-YL]-2-[2,10,14-TRIMETHYLHEXADECAN-16-YL]GLYCEROL, 2,10,23-TRIMETHYL-TETRACOSANE, PROTEIN (BACTERIORHODOPSIN), ... | 著者 | Luecke, H. | 登録日 | 1999-07-29 | 公開日 | 1999-10-20 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural changes in bacteriorhodopsin during ion transport at 2 angstrom resolution. Science, 286, 1999
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1C3W
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![BU of 1c3w by Molmil](/molmil-images/mine/1c3w) | BACTERIORHODOPSIN/LIPID COMPLEX AT 1.55 A RESOLUTION | 分子名称: | 1-[2,6,10.14-TETRAMETHYL-HEXADECAN-16-YL]-2-[2,10,14-TRIMETHYLHEXADECAN-16-YL]GLYCEROL, 2,10,23-TRIMETHYL-TETRACOSANE, BACTERIORHODOPSIN (GROUND STATE WILD TYPE "BR"), ... | 著者 | Luecke, H. | 登録日 | 1999-07-28 | 公開日 | 1999-09-15 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structure of bacteriorhodopsin at 1.55 A resolution. J.Mol.Biol., 291, 1999
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7L5R
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![BU of 7l5r by Molmil](/molmil-images/mine/7l5r) | Crystal Structure of the Oxacillin-hydrolyzing Class D Extended-spectrum Beta-lactamase OXA-14 from Pseudomonas aeruginosa | 分子名称: | Beta-lactamase, GLYCEROL, SULFATE ION | 著者 | Minasov, G, Shuvalova, L, Rosas-Lemus, M, Brunzelle, J.S, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2020-12-22 | 公開日 | 2021-12-29 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Functional and Structural Characterization of OXA-935, a Novel OXA-10-Family beta-Lactamase from Pseudomonas aeruginosa. Antimicrob.Agents Chemother., 66, 2022
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8DL4
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![BU of 8dl4 by Molmil](/molmil-images/mine/8dl4) | S. CEREVISIAE CYP51 COMPLEXED WITH Courmarin-containing INHIBITOR | 分子名称: | 7-(diethylamino)-N-[(2S)-2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]-2-oxo-2H-1-benzopyran-3-carboxamide, Lanosterol 14-alpha demethylase, PENTAETHYLENE GLYCOL, ... | 著者 | Ruma, Y.N, Keniya, M.V, Tyndall, J.D, Monk, B.C. | 登録日 | 2022-07-06 | 公開日 | 2022-08-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | S. CEREVISIAE CYP51 COMPLEXED WITH Courmarin-containing INHIBITOR To Be Published
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6NAH
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![BU of 6nah by Molmil](/molmil-images/mine/6nah) | |
5H9N
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![BU of 5h9n by Molmil](/molmil-images/mine/5h9n) | Crystal structure of LTBP1 Y114A mutant in complex with leukotriene C4 | 分子名称: | (5~{S},6~{R},7~{E},9~{E},11~{Z},14~{Z})-6-[(2~{R})-2-[[(4~{S})-4-azanyl-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]-3-(2-hydroxy-2-oxoethylamino)-3-oxidanylidene-propyl]sulfanyl-5-oxidanyl-icosa-7,9,11,14-tetraenoic acid, Lipocalin AI-4 | 著者 | Andersen, J.F. | 登録日 | 2015-12-28 | 公開日 | 2016-05-11 | 最終更新日 | 2017-05-24 | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | 主引用文献 | Structure and Ligand-Binding Mechanism of a Cysteinyl Leukotriene-Binding Protein from a Blood-Feeding Disease Vector. Acs Chem.Biol., 11, 2016
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5HA0
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![BU of 5ha0 by Molmil](/molmil-images/mine/5ha0) | Crystal structure of the LTBP1 leukotriene d4 complex | 分子名称: | (5~{S},6~{R},7~{E},9~{E},11~{Z},14~{Z})-6-[(2~{R})-2-azanyl-3-(2-hydroxy-2-oxoethylamino)-3-oxidanylidene-propyl]sulfanyl-5-oxidanyl-icosa-7,9,11,14-tetraenoic acid, Lipocalin AI-4 | 著者 | Andersen, J.F. | 登録日 | 2015-12-29 | 公開日 | 2016-05-11 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.441 Å) | 主引用文献 | Structure and Ligand-Binding Mechanism of a Cysteinyl Leukotriene-Binding Protein from a Blood-Feeding Disease Vector. Acs Chem.Biol., 11, 2016
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5F15
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![BU of 5f15 by Molmil](/molmil-images/mine/5f15) | Crystal Structure of ArnT from Cupriavidus metallidurans bound to Undecaprenyl phosphate | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-amino-4-deoxy-L-arabinose (L-Ara4N) transferase, CHLORIDE ION, ... | 著者 | Petrou, V.I, Clarke, O.B, Tomasek, D, Banerjee, S, Rajashankar, K.R, Mancia, F, New York Consortium on Membrane Protein Structure (NYCOMPS) | 登録日 | 2015-11-30 | 公開日 | 2016-02-17 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structures of aminoarabinose transferase ArnT suggest a molecular basis for lipid A glycosylation. Science, 351, 2016
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5J7A
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![BU of 5j7a by Molmil](/molmil-images/mine/5j7a) | Bacteriorhodopsin ground state structure obtained with Serial Femtosecond Crystallography | 分子名称: | 1-[2,6,10.14-TETRAMETHYL-HEXADECAN-16-YL]-2-[2,10,14-TRIMETHYLHEXADECAN-16-YL]GLYCEROL, Bacteriorhodopsin, RETINAL | 著者 | Nogly, P, Panneels, V, Nelson, G, Gati, C, Kimura, T, Milne, C, Milathianaki, D, Kubo, M, Wu, W, Conrad, C, Coe, J, Bean, R, Zhao, Y, Bath, P, Dods, R, Harimoorthy, R, Beyerlein, K.R, Rheinberger, J, James, D, DePonte, D, Li, C, Sala, L, Williams, G, Hunter, M, Koglin, J.E, Berntsen, P, Nango, E, Iwata, S, Chapman, H.N, Fromme, P, Frank, M, Abela, R, Boutet, S, Barty, A, White, T.A, Weierstall, U, Spence, J, Neutze, R, Schertler, G, Standfuss, J. | 登録日 | 2016-04-06 | 公開日 | 2016-08-31 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Lipidic cubic phase injector is a viable crystal delivery system for time-resolved serial crystallography. Nat Commun, 7, 2016
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5Y4H
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![BU of 5y4h by Molmil](/molmil-images/mine/5y4h) | Human SIRT3 in complex with halistanol sulfate | 分子名称: | NAD-dependent protein deacetylase sirtuin-3, mitochondrial, THr-Arg-Ser-GLY-ALY-VAL-MET-ARG-ARG-LEU-ARG-ARG, ... | 著者 | Kudo, N, Ito, A, Yoshida, M. | 登録日 | 2017-08-03 | 公開日 | 2018-05-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Halistanol sulfates I and J, new SIRT1-3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria J. Antibiot., 71, 2018
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2QZK
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![BU of 2qzk by Molmil](/molmil-images/mine/2qzk) | Crystal structure of human Beta Secretase complexed with I21 | 分子名称: | 2-[(5R)-5-amino-5-methyl-4,16-dioxo-14-phenyl-3-oxa-15-azatricyclo[15.3.1.1~7,11~]docosa-1(21),7(22),8,10,12,14,17,19-octaen-19-yl]benzonitrile, Beta-secretase 1 | 著者 | Munshi, S. | 登録日 | 2007-08-16 | 公開日 | 2008-04-29 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Strategies toward improving the brain penetration of macrocyclic tertiary carbinamine BACE-1 inhibitors. Bioorg.Med.Chem.Lett., 17, 2007
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8IUG
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![BU of 8iug by Molmil](/molmil-images/mine/8iug) | Cryo-EM structure of the RC-LH core complex from roseiflexus castenholzii | 分子名称: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 2-O-octyl-beta-D-glucopyranose, ... | 著者 | Wang, G.-L, Qi, C.-H, Yu, L.-J. | 登録日 | 2023-03-24 | 公開日 | 2023-11-22 | 最終更新日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | 主引用文献 | New insights on the photocomplex of Roseiflexus castenholzii revealed from comparisons of native and carotenoid-depleted complexes. J.Biol.Chem., 299, 2023
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2M1P
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![BU of 2m1p by Molmil](/molmil-images/mine/2m1p) | [Aba5,14]BTD-2 | 分子名称: | [Aba5,14]BTD-2 | 著者 | Conibear, A.C, Rosengren, K, Daly, N.L, Troiera Henriques, S, Craik, D.J. | 登録日 | 2012-12-04 | 公開日 | 2013-02-27 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | The cyclic cystine ladder in theta-defensins is important for structure and stability, but not antibacterial activity. J.Biol.Chem., 288, 2013
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4ZHX
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![BU of 4zhx by Molmil](/molmil-images/mine/4zhx) | Novel binding site for allosteric activation of AMPK | 分子名称: | (5S,6R,7R,9R,13cR,14R,16aS)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,14,15,16,16a-octahydro-5H,13cH-5,9-epoxy-4b,9a,1 5-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-ol, 3-[4-(2-hydroxyphenyl)phenyl]-4-oxidanyl-6-oxidanylidene-7H-thieno[2,3-b]pyridine-5-carbonitrile, 5'-AMP-activated protein kinase catalytic subunit alpha-2, ... | 著者 | Langendorf, C.G, Ngoei, K.R, Issa, S.M.A, Ling, N, Gorman, M.A, Parker, M.W, Sakamoto, K, Scott, J.W, Oakhill, J.S, Kemp, B.E. | 登録日 | 2015-04-27 | 公開日 | 2016-03-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | 主引用文献 | Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding. Nat Commun, 7, 2016
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7D5L
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![BU of 7d5l by Molmil](/molmil-images/mine/7d5l) | Discovery of BMS-986144, a Third Generation, Pan Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection | 分子名称: | NS3/4A Protease, ZINC ION, [1,1,1-tris(fluoranyl)-2-methyl-propan-2-yl] ~{N}-[(1~{S},4~{R},6~{S},7~{Z},11~{R},13~{R},14~{S},18~{R})-13-ethyl-18-(7-fluoranyl-6-methoxy-isoquinolin-1-yl)oxy-11-methyl-4-[(1-methylcyclopropyl)sulfonylcarbamoyl]-2,15-bis(oxidanylidene)-3,16-diazatricyclo[14.3.0.0^{4,6}]nonadec-7-en-14-yl]carbamate | 著者 | Ghosh, K, Anumula, R, Kumar, A. | 登録日 | 2020-09-26 | 公開日 | 2020-12-16 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Discovery of BMS-986144, a Third-Generation, Pan-Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection. J.Med.Chem., 63, 2020
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