7Z6J
 
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3KAS
 | | Machupo virus GP1 bound to human transferrin receptor 1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein, ... | | 著者 | Abraham, J, Corbett, K.D, Harrison, S.C. | | 登録日 | 2009-10-19 | | 公開日 | 2010-03-09 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis for receptor recognition by New World hemorrhagic fever arenaviruses.
Nat.Struct.Mol.Biol., 17, 2010
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8XJ2
 | | MAT2A in complex with SAM and allosteric inhibitor SCR-7952 | | 分子名称: | 7-chloranyl-5-(2-cyclopropylpyridin-3-yl)-1-methyl-imidazo[4,5-c]quinolin-4-one, S-ADENOSYLMETHIONINE, S-adenosylmethionine synthase isoform type-2 | | 著者 | Zhou, F. | | 登録日 | 2023-12-20 | | 公開日 | 2024-12-25 | | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | | 主引用文献 | MAT2A in complex with SAM and allosteric inhibitor SCR-7952
To Be Published
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5GSA
 | | EED in complex with an allosteric PRC2 inhibitor | | 分子名称: | Histone-lysine N-methyltransferase EZH2, N-(furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, Polycomb protein EED | | 著者 | Zhao, K, Zhao, M, Luo, X, Zhang, H. | | 登録日 | 2016-08-15 | | 公開日 | 2017-02-01 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | | 主引用文献 | An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of
Nat. Chem. Biol., 13, 2017
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6HM5
 | | Crystal structure of TOPBP1 BRCT0,1,2 in complex with a RAD9 phosphopeptide | | 分子名称: | Cell cycle checkpoint control protein RAD9A, DNA topoisomerase II binding protein 1 | | 著者 | Day, M, Rappas, M, Oliver, A.W, Pearl, L.H. | | 登録日 | 2018-09-12 | | 公開日 | 2018-10-17 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.330038 Å) | | 主引用文献 | BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands.
Elife, 7, 2018
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5JF8
 | | Crystal structure of type 2 PDF from Streptococcus agalactiae in complex with inhibitor RAS358 (21) | | 分子名称: | ACETATE ION, IMIDAZOLE, Peptide deformylase, ... | | 著者 | Fieulaine, S, Giglione, C, Meinnel, T. | | 登録日 | 2016-04-19 | | 公開日 | 2016-11-30 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | A unique peptide deformylase platform to rationally design and challenge novel active compounds.
Sci Rep, 6, 2016
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5GVE
 | | Human TOP3B-TDRD3 complex | | 分子名称: | DNA topoisomerase 3-beta-1, MAGNESIUM ION, Tudor domain-containing protein 3 | | 著者 | Goto-Ito, S, Yamagata, A, Sato, Y, Takahashi, T.S, Fukai, S. | | 登録日 | 2016-09-05 | | 公開日 | 2017-06-14 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.606 Å) | | 主引用文献 | Structural basis of the interaction between Topoisomerase III beta and the TDRD3 auxiliary factor
Sci Rep, 7, 2017
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7S7A
 | | Crystal structure of CDK2 liganded with compound EF3019 | | 分子名称: | 1,2-ETHANEDIOL, 2-{[2-(2H-indazol-3-yl)ethyl]amino}-5-(trifluoromethyl)benzoic acid, Cyclin-dependent kinase 2 | | 著者 | Sun, L, Schonbrunn, E. | | 登録日 | 2021-09-15 | | 公開日 | 2022-09-28 | | 最終更新日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice.
J.Med.Chem., 66, 2023
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3NEG
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5GJP
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6EUH
 | | The GH43, Beta 1,3 Galactosidase, BT3683 with galactodeoxynojirimycin | | 分子名称: | (2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol, Beta-glucanase, CALCIUM ION | | 著者 | Cartmell, A, Gilbert, H.J. | | 登録日 | 2017-10-30 | | 公開日 | 2018-10-17 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A surface endogalactanase in Bacteroides thetaiotaomicron confers keystone status for arabinogalactan degradation.
Nat Microbiol, 3, 2018
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9BLP
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8IA5
 | | Small peptide enhances the binding of nutline-3a to N-terminal domain of MdmX | | 分子名称: | 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, 9-mer peptide, ... | | 著者 | Cheng, X.Y, Wei, Q.Y, Huang, Y, Su, Z.D. | | 登録日 | 2023-02-07 | | 公開日 | 2023-02-22 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Small peptide enhances the binding of nutline-3a to N-terminal domain of MdmX
To Be Published
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9W49
 | | Cryo-EM structure of human kappa opioid receptor -G protein signaling complex bound with U-50488H | | 分子名称: | 2-(3,4-dichlorophenyl)-~{N}-methyl-~{N}-[(1~{R},2~{R})-2-pyrrolidin-1-ylcyclohexyl]ethanamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Suno-Ikeda, C, Takai, T, Hirose, M, Inoue, A, Sugita, Y, Kato, T, Kobayashi, T, Suno, R. | | 登録日 | 2025-07-31 | | 公開日 | 2025-11-19 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural and dynamic insights into the biased signaling mechanism of the human kappa opioid receptor.
Nat Commun, 16, 2025
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4ZKV
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3K8L
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7UCH
 | | AprA Methyltransferase 1 - GNAT in complex with Mn2+ , SAM, and Di-methyl-malonate | | 分子名称: | AprA Methyltransferase 1, GLYCEROL, MANGANESE (II) ION, ... | | 著者 | Skiba, M.A, Lao, Y, Smith, J.L. | | 登録日 | 2022-03-16 | | 公開日 | 2022-06-01 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | | 主引用文献 | Structural Basis for Control of Methylation Extent in Polyketide Synthase Metal-Dependent C -Methyltransferases.
Acs Chem.Biol., 17, 2022
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4ZOA
 | | Crystal Structure of beta-glucosidase from Listeria innocua in complex with isofagomine | | 分子名称: | 5-HYDROXYMETHYL-3,4-DIHYDROXYPIPERIDINE, DI(HYDROXYETHYL)ETHER, Lin1840 protein, ... | | 著者 | Nakajima, M, Yoshida, R, Miyanaga, A, Abe, K, Takahashi, Y, Sugimoto, N, Toyoizumi, H, Nakai, H, Kitaoka, M, Taguchi, H. | | 登録日 | 2015-05-06 | | 公開日 | 2016-05-18 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | | 主引用文献 | Functional and Structural Analysis of a beta-Glucosidase Involved in beta-1,2-Glucan Metabolism in Listeria innocua
Plos One, 11, 2016
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4O5O
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9JBE
 | | Cryo-EM structure of the human LYCHOS in complex with cholesterol and cholesteryl hemisuccinate in the contracted state | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, CHOLESTEROL, ... | | 著者 | Yu, S, Liang, L. | | 登録日 | 2024-08-27 | | 公開日 | 2025-07-16 | | 最終更新日 | 2025-08-27 | | 実験手法 | ELECTRON MICROSCOPY (3.31 Å) | | 主引用文献 | Structural insights into cholesterol sensing by the LYCHOS-mTORC1 pathway.
Nat Commun, 16, 2025
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4NRU
 | | Murine Norovirus RNA-dependent-RNA-polymerase in complex with Compound 6, a suramin derivative | | 分子名称: | 4-({4-methyl-3-[(3-nitrobenzoyl)amino]benzoyl}amino)naphthalene-1,5-disulfonic acid, MAGNESIUM ION, RNA dependent RNA polymerase | | 著者 | Milani, M, Croci, R, Pezzullo, M, Tarantino, D, Mastrangelo, E, Bolognesi, M. | | 登録日 | 2013-11-27 | | 公開日 | 2014-10-15 | | 最終更新日 | 2024-11-27 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds.
Plos One, 9, 2014
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7YRY
 | | F1-ATPase of Acinetobacter baumannii | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... | | 著者 | Saw, W.-G, Grueber, G. | | 登録日 | 2022-08-11 | | 公開日 | 2023-06-21 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Atomic insights of an up and down conformation of the Acinetobacter baumannii F 1 -ATPase subunit epsilon and deciphering the residues critical for ATP hydrolysis inhibition and ATP synthesis.
Faseb J., 37, 2023
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8XJF
 | | Crystal structure of Arabidopsis N-amino acetyltransferase 2 bound to HEPES, Acetyl CoA, GABA, and glycerol | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETYL COENZYME *A, GAMMA-AMINO-BUTANOIC ACID, ... | | 著者 | Arold, S.T, Hameed, U.F.S. | | 登録日 | 2023-12-21 | | 公開日 | 2024-12-25 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of Arabidopsis N-amino acetyltransferase 2 bound to HEPES, Acetyl CoA, GABA, and glycerol
To Be Published
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4NYH
 | | Orthorhombic crystal form of pir1 dual specificity phosphatase core | | 分子名称: | CHLORIDE ION, PHOSPHATE ION, RNA/RNP complex-1-interacting phosphatase | | 著者 | Sankhala, R.S, Lokareddy, R.K, Cingolani, G. | | 登録日 | 2013-12-10 | | 公開日 | 2014-01-08 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Structure of Human PIR1, an Atypical Dual-Specificity Phosphatase.
Biochemistry, 53, 2014
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5A71
 | | Open and closed conformations and protonation states of Candida antarctica Lipase B: atomic resolution native | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ISOPROPYL ALCOHOL, LIPASE B, ... | | 著者 | Stauch, B, Fisher, S.J, Cianci, M. | | 登録日 | 2015-07-02 | | 公開日 | 2015-10-21 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (0.91 Å) | | 主引用文献 | Open and Closed States of Candida Antarctica Lipase B: Protonation and the Mechanism of Interfacial Activation.
J.Lipid Res., 56, 2015
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