5DJV
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5DJR
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![BU of 5djr by Molmil](/molmil-images/mine/5djr) | Crystal structure of human FPPS in complex with biaryl compound 6 | 分子名称: | 1H,1'H-4,4'-biindole-2-carboxylic acid, Farnesyl pyrophosphate synthase, GLYCEROL, ... | 著者 | Rondeau, J.M, Bourgier, E, Lehmann, S. | 登録日 | 2015-09-02 | 公開日 | 2015-09-30 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding. Chemmedchem, 10, 2015
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2RND
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3HVC
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![BU of 3hvc by Molmil](/molmil-images/mine/3hvc) | Crystal structure of human p38alpha MAP kinase | 分子名称: | 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE, Mitogen-activated protein kinase 14 | 著者 | Perry, J.J, Tainer, J.A. | 登録日 | 2009-06-15 | 公開日 | 2009-06-30 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | p38alpha MAP kinase C-terminal domain binding pocket characterized by crystallographic and computational analyses. J.Mol.Biol., 391, 2009
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2RMY
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7W3O
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![BU of 7w3o by Molmil](/molmil-images/mine/7w3o) | Crystal structure of human CYB5R3 | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, NADH-cytochrome b5 reductase 3 soluble form | 著者 | Noda, N.N. | 登録日 | 2021-11-25 | 公開日 | 2022-12-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3. Nat Commun, 13, 2022
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8PK0
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![BU of 8pk0 by Molmil](/molmil-images/mine/8pk0) | human mitoribosomal large subunit assembly intermediate 1 with GTPBP10-GTPBP7 | 分子名称: | 16S rRNA + pre-H68-71 segment, 39S ribosomal protein L10, mitochondrial, ... | 著者 | Kummer, E, Nguyen, T.G, Ritter, C. | 登録日 | 2023-06-23 | 公開日 | 2023-12-13 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | 主引用文献 | Structural insights into the role of GTPBP10 in the RNA maturation of the mitoribosome. Nat Commun, 14, 2023
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7UQB
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![BU of 7uqb by Molmil](/molmil-images/mine/7uqb) | Nucleoplasmic pre-60S intermediate of the Nog2 containing pre-rotation state from a SPB1-D52A strain with AlF4 | 分子名称: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 25S rRNA, 5.8S rRNA, ... | 著者 | Sekulski, K, Cruz, V.E, Weirich, C.S, Erzberger, J.P. | 登録日 | 2022-04-19 | 公開日 | 2023-03-15 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.43 Å) | 主引用文献 | rRNA methylation by Spb1 regulates the GTPase activity of Nog2 during 60S ribosomal subunit assembly. Nat Commun, 14, 2023
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7UOO
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![BU of 7uoo by Molmil](/molmil-images/mine/7uoo) | Nucleoplasmic pre-60S intermediate of the Nog2 containing pre-rotation state | 分子名称: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 25S rRNA, 5.8S rRNA, ... | 著者 | Sekulski, K, Cruz, V.E, Weirich, C.S, Erzberger, J.P. | 登録日 | 2022-04-13 | 公開日 | 2023-03-15 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.34 Å) | 主引用文献 | rRNA methylation by Spb1 regulates the GTPase activity of Nog2 during 60S ribosomal subunit assembly. Nat Commun, 14, 2023
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7UQZ
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![BU of 7uqz by Molmil](/molmil-images/mine/7uqz) | Nucleoplasmic pre-60S intermediate of the Nog2 containing pre-rotation state from a SPB1 D52A strain | 分子名称: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 25S rRNA, 5.8S rRNA, ... | 著者 | Sekulski, K, Cruz, V.E, Weirich, C.S, Erzberger, J.P. | 登録日 | 2022-04-20 | 公開日 | 2023-03-15 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.44 Å) | 主引用文献 | rRNA methylation by Spb1 regulates the GTPase activity of Nog2 during 60S ribosomal subunit assembly. Nat Commun, 14, 2023
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7V08
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![BU of 7v08 by Molmil](/molmil-images/mine/7v08) | Nucleoplasmic pre-60S intermediate of the Nog2 containing pre-rotation state from a Spb1 D52A suppressor 3 strain | 分子名称: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 25S rRNA, 5.8S rRNA, ... | 著者 | Sekulski, K, Cruz, V.E, Weirich, C.S, Erzberger, J.P. | 登録日 | 2022-05-10 | 公開日 | 2023-03-15 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.36 Å) | 主引用文献 | rRNA methylation by Spb1 regulates the GTPase activity of Nog2 during 60S ribosomal subunit assembly. Nat Commun, 14, 2023
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3F0M
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3F0L
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5OOM
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![BU of 5oom by Molmil](/molmil-images/mine/5oom) | Structure of a native assembly intermediate of the human mitochondrial ribosome with unfolded interfacial rRNA | 分子名称: | 16S ribosomal RNA, 39S ribosomal protein L10, mitochondrial, ... | 著者 | Brown, A, Rathore, S, Kimanius, D, Aibara, S, Bai, X.C, Rorbach, J, Amunts, A, Ramakrishnan, V. | 登録日 | 2017-08-08 | 公開日 | 2017-09-13 | 最終更新日 | 2023-03-15 | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | 主引用文献 | Structures of the human mitochondrial ribosome in native states of assembly. Nat. Struct. Mol. Biol., 24, 2017
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8QU5
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![BU of 8qu5 by Molmil](/molmil-images/mine/8qu5) | mt-LSU assembly intermediate in GTPBP8 knock-out cells, state 2 | 分子名称: | 16S ribosomal RNA, 39S ribosomal protein L10, mitochondrial, ... | 著者 | Valentin Gese, G, Cipullo, M, Rorbach, J, Hallberg, B.M. | 登録日 | 2023-10-13 | 公開日 | 2024-06-26 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.42 Å) | 主引用文献 | GTPBP8 plays a role in mitoribosome formation in human mitochondria. Nat Commun, 15, 2024
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5XJL
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3FWN
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![BU of 3fwn by Molmil](/molmil-images/mine/3fwn) | Dimeric 6-phosphogluconate dehydrogenase complexed with 6-phosphogluconate and 2'-monophosphoadenosine-5'-diphosphate | 分子名称: | 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, 6-PHOSPHOGLUCONIC ACID, 6-phosphogluconate dehydrogenase, ... | 著者 | Chen, Y.-Y, Ko, T.-P, Lo, L.-P, Lin, C.-H, Wang, A.H.-J. | 登録日 | 2009-01-19 | 公開日 | 2009-09-01 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Conformational changes associated with cofactor/substrate binding of 6-phosphogluconate dehydrogenase from Escherichia coli and Klebsiella pneumoniae: Implications for enzyme mechanism J.Struct.Biol., 169, 2010
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4RSE
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![BU of 4rse by Molmil](/molmil-images/mine/4rse) | Crystal structure of RPE65 in complex with MB-001 and palmitate | 分子名称: | (1R)-3-amino-1-{3-[(2,6,6-trimethylcyclohex-1-en-1-yl)methoxy]phenyl}propan-1-ol, FE (II) ION, PALMITIC ACID, ... | 著者 | Kiser, P.D, Shi, W, Palczewski, K. | 登録日 | 2014-11-07 | 公開日 | 2015-04-15 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Catalytic mechanism of a retinoid isomerase essential for vertebrate vision. Nat.Chem.Biol., 11, 2015
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4RSC
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![BU of 4rsc by Molmil](/molmil-images/mine/4rsc) | Crystal structure of RPE65 in complex with emixustat and palmitate | 分子名称: | (1R)-3-amino-1-[3-(cyclohexylmethoxy)phenyl]propan-1-ol, FE (II) ION, PALMITIC ACID, ... | 著者 | Kiser, P.D, Shi, W, Palczewski, K. | 登録日 | 2014-11-07 | 公開日 | 2015-04-15 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Catalytic mechanism of a retinoid isomerase essential for vertebrate vision. Nat.Chem.Biol., 11, 2015
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4FXF
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6L3A
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![BU of 6l3a by Molmil](/molmil-images/mine/6l3a) | Cytochrome P450 107G1 (RapN) with everolimus | 分子名称: | Cytochrome P450, Everolimus, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Km, V.C, Kim, D.H, Lim, Y.R, Lee, I.H, Lee, J.H, Kang, L.W. | 登録日 | 2019-10-10 | 公開日 | 2020-09-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural insights into CYP107G1 from rapamycin-producing Streptomyces rapamycinicus. Arch.Biochem.Biophys., 692, 2020
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4FXJ
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6L39
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![BU of 6l39 by Molmil](/molmil-images/mine/6l39) | Cytochrome P450 107G1 (RapN) | 分子名称: | Cytochrome P450, DI(HYDROXYETHYL)ETHER, PHOSPHATE ION, ... | 著者 | Kim, V.C, Kim, D.H, Lim, Y.R, Lee, I.H, Lee, J.H, Kang, L.W. | 登録日 | 2019-10-10 | 公開日 | 2020-09-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.97 Å) | 主引用文献 | Structural insights into CYP107G1 from rapamycin-producing Streptomyces rapamycinicus. Arch.Biochem.Biophys., 692, 2020
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7NND
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7NMX
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