5XJL

Crystal Structure of the Gemin2-binding domain of SMN, Gemin2 in Complex with SmD1/D2/F/E/G from Human

Replaces:  3S6N

Summary for 5XJL

• Entry DOI: 10.2210/pdb5xjl/pdb
• Descriptor: Gem-associated protein 2, Small nuclear ribonucleoprotein Sm D1, Small nuclear ribonucleoprotein Sm D2, ... (8 entities in total)
• Functional Keywords: splicing
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus, gem: O14893 Q16637; Cytoplasm, cytosol : P62314 P62316 P62304 P62306 P62308
• Total number of polymer chains: 7
• Total formula weight: 91589.90

Authors

Zhang, R. (deposition date: 2017-05-02, release date: 2018-05-02, Last modification date: 2024-03-27)

• Primary citation: Zhang, R.,So, B.R.,Li, P.,Yong, J.,Glisovic, T.,Wan, L.,Dreyfuss, G.; Structure of a key intermediate of the SMN complex reveals Gemin2's crucial function in snRNP assembly; Cell, 146:384-395, 2011; PubMed: 21816274; DOI: 10.1016/j.cell.2011.06.043

Experimental method

X-RAY DIFFRACTION (2.5 Å)