PDB: 595 件ウェブページステータス検索Chemie searchBIRD

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1RQQ	Crystal Structure of the Insulin Receptor Kinase in Complex with the SH2 Domain of APS 分子名称: BISUBSTRATE INHIBITOR, Insulin receptor, MANGANESE (II) ION, ... 著者 Hu, J, Liu, J, Ghirlando, R, Saltiel, A.R, Hubbard, S.R. 登録日 2003-12-06 公開日 2003-12-30 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor. Mol.Cell, 12, 2003
1RPY	CRYSTAL STRUCTURE OF THE DIMERIC SH2 DOMAIN OF APS 分子名称: SULFATE ION, adaptor protein APS 著者 Hu, J, Liu, J, Ghirlando, R, Saltiel, A.R, Hubbard, S.R. 登録日 2003-12-03 公開日 2003-12-23 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor. Mol.Cell, 12, 2003
1RJA	Solution Structure and Backbone Dynamics of the Nonreceptor Tyrosine Kinase PTK6/Brk SH2 Domain 分子名称: Tyrosine-protein kinase 6 著者 Hong, E, Shin, J, Lee, W. 登録日 2003-11-18 公開日 2004-07-20 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Solution Structure and Backbone Dynamics of the Non-receptor Protein-tyrosine Kinase-6 Src Homology 2 Domain J.Biol.Chem., 279, 2004
1R1S	Structural Basis for Differential Recognition of Tyrosine Phosphorylated Sites in the Linker for Activation of T cells (LAT) by the Adaptor Protein Gads 分子名称: GRB2-related adaptor protein 2, LAT pY226 peptide, SULFATE ION 著者 Cho, S, Mariuzza, R.A. 登録日 2003-09-24 公開日 2004-09-28 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads. Embo J., 23, 2004
1R1Q	Structural Basis for Differential Recognition of Tyrosine Phosphorylated Sites in the Linker for Activation of T cells (LAT) by the Adaptor Protein Gads 分子名称: GRB2-related adaptor protein 2, LAT pY191 peptide, SULFATE ION 著者 Cho, S, Mariuzza, R.A. 登録日 2003-09-24 公開日 2004-09-28 最終更新日 2018-04-04 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads. Embo J., 23, 2004
1R1P	Structural Basis for Differential Recognition of Tyrosine Phosphorylated Sites in the Linker for Activation of T cells (LAT) by the Adaptor Protein Gads 分子名称: GRB2-related adaptor protein 2, LAT pY171 peptide, SULFATE ION 著者 Cho, S, Mariuzza, R.A. 登録日 2003-09-24 公開日 2004-09-28 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads. Embo J., 23, 2004
1QG1	GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN COMPLEXED WITH AN SHC-DERIVED PEPTIDE 分子名称: PROTEIN (GROWTH FACTOR RECEPTOR BINDING PROTEIN), PROTEIN (SHC-DERIVED PEPTIDE) 著者 Ogura, K. 登録日 1999-04-19 公開日 1999-04-27 最終更新日 2023-12-27 実験手法 SOLUTION NMR 主引用文献 Solution structure of the SH2 domain of Grb2 complexed with the Shc-derived phosphotyrosine-containing peptide. J.Mol.Biol., 289, 1999
1QCF	CRYSTAL STRUCTURE OF HCK IN COMPLEX WITH A SRC FAMILY-SELECTIVE TYROSINE KINASE INHIBITOR 分子名称: 1-TER-BUTYL-3-P-TOLYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE, Tyrosine-protein kinase HCK 著者 Schindler, T, Sicheri, F, Pico, A, Gazit, A, Levitzki, A, Kuriyan, J. 登録日 1999-05-04 公開日 1999-06-08 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor. Mol.Cell, 3, 1999
1QAD	Crystal Structure of the C-Terminal SH2 Domain of the P85 alpha Regulatory Subunit of Phosphoinositide 3-Kinase: An SH2 domain mimicking its own substrate 分子名称: PI3-KINASE P85 ALPHA SUBUNIT 著者 Hoedemaeker, P.J, Siegal, G, Roe, M, Driscoll, P.C, Abrahams, J.P.A. 登録日 1999-02-26 公開日 1999-10-27 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of the C-terminal SH2 domain of the p85alpha regulatory subunit of phosphoinositide 3-kinase: an SH2 domain mimicking its own substrate. J.Mol.Biol., 292, 1999
1PIC	PHOSPHATIDYLINOSITOL 3-KINASE, P85-ALPHA SUBUNIT: C-TERMINAL SH2 DOMAIN COMPLEXED WITH A TYR751 PHOSPHOPEPTIDE FROM THE PDGF RECEPTOR, NMR, MINIMIZED MEAN STRUCTURE 分子名称: BETA-PLATELET-DERIVED GROWTH FACTOR RECEPTOR, PHOSPHATIDYLINOSITOL 3-KINASE 著者 Breeze, A.L, Kara, B.V, Barratt, D.G, Anderson, M, Smith, J.C, Luke, R.W, Best, J.R, Cartlidge, S.A. 登録日 1997-06-23 公開日 1997-09-17 最終更新日 2022-02-23 実験手法 SOLUTION NMR 主引用文献 Structure of a specific peptide complex of the carboxy-terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3-kinase. EMBO J., 15, 1996
1P13	Crystal Structure of the Src SH2 Domain Complexed with Peptide (SDpYANFK) 分子名称: CACODYLATE ION, Peptide, Proto-oncogene tyrosine-protein kinase Src 著者 Sonnenburg, E.D, Bilwes, A, Hunter, T, Noel, J.P. 登録日 2003-04-11 公開日 2003-08-19 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 The structure of the membrane distal phosphatase domain of RPTPalpha reveals interdomain flexibility and an SH2 domain interaction region. Biochemistry, 42, 2003
1OPL	Structural basis for the auto-inhibition of c-Abl tyrosine kinase 分子名称: 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, MYRISTIC ACID, proto-oncogene tyrosine-protein kinase 著者 Nagar, B, Hantschel, O, Young, M.A, Scheffzek, K, Veach, D, Bornmann, W, Clarkson, B, Superti-Furga, G, Kuriyan, J. 登録日 2003-03-06 公開日 2003-04-08 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (3.42 Å) 主引用文献 Structural basis for the autoinhibition of c-Abl tyrosine kinase Cell(Cambridge,Mass.), 112, 2003
1OPK	Structural basis for the auto-inhibition of c-Abl tyrosine kinase 分子名称: 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, GLYCEROL, MYRISTIC ACID, ... 著者 Nagar, B, Hantschel, O, Young, M.A, Scheffzek, K, Veach, D, Bornmann, W, Clarkson, B, Superti-Furga, G, Kuriyan, J. 登録日 2003-03-06 公開日 2003-04-08 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural basis for the autoinhibition of c-Abl tyrosine kinase Cell(Cambridge,Mass.), 112, 2003
1OO4	P395S mutant of the p85 regulatory subunit of the N-terminal src homology 2 domain of PI3-Kinase complexed to a peptide derived from PDGFr 分子名称: 8-mer peptide from PDGFr, Phosphatidylinositol 3-kinase regulatory alpha subunit 著者 Guenther, U.L, Weyrauch, B, Schaffhausen, B. 登録日 2003-03-03 公開日 2003-03-25 最終更新日 2023-11-15 実験手法 SOLUTION NMR 主引用文献 Nuclear magnetic resonance structure of the P395S mutant of the N-SH2 domain of the p85 subunit of PI3 kinase: an SH2 domain with altered specificity Biochemistry, 42, 2003
1OO3	P395S mutant of the p85 regulatory subunit of the N-terminal src homology 2 domain of PI3-Kinase 分子名称: Phosphatidylinositol 3-kinase regulatory alpha subunit 著者 Guenther, U.L, Weyrauch, B, Schaffhausen, B. 登録日 2003-03-03 公開日 2003-03-25 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Nuclear magnetic resonance structure of the P395S mutant of the N-SH2 domain of the p85 subunit of PI3 kinase: an SH2 domain with altered specificity Biochemistry, 42, 2003
1O4R	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78783. 分子名称: (PHENYL-PHOSPHONO-METHYL)-PHOSPHONIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 著者 Lange, G, Loenze, P, Liesum, A. 登録日 2003-06-15 公開日 2004-02-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4Q	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU79256. 分子名称: PHENYL(SULFO)ACETIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 著者 Lange, G, Loenze, P, Liesum, A. 登録日 2003-06-15 公開日 2004-02-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4P	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78791. 分子名称: 2-PHENYLMALONIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 著者 Lange, G, Loenze, P, Liesum, A. 登録日 2003-06-15 公開日 2004-02-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4O	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PHENYLPHOSPHATE. 分子名称: PHENYL DIHYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 著者 Lange, G, Loenze, P, Liesum, A. 登録日 2003-06-15 公開日 2004-02-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4N	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH OXALIC ACID. 分子名称: OXALIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 著者 Lange, G, Loenze, P, Liesum, A. 登録日 2003-06-15 公開日 2004-02-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4M	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH MALONICACID. 分子名称: MALONIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 著者 Lange, G, Loenze, P, Liesum, A. 登録日 2003-06-15 公開日 2004-02-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4L	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH FRAGMENT2. 分子名称: CITRIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 著者 Lange, G, Loenze, P, Liesum, A. 登録日 2003-06-15 公開日 2004-02-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4K	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PASBN. 分子名称: BENZYL 2-FORMYLPHENYL HYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 著者 Lange, G, Loenze, P, Liesum, A. 登録日 2003-06-15 公開日 2004-02-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4J	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH ISO24. 分子名称: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, [(4-ETHYLPHENYL)AMINO]CARBONYLPHOSPHONIC ACID 著者 Lange, G, Loenze, P, Liesum, A. 登録日 2003-06-15 公開日 2004-02-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003
1O4I	CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PAS219. 分子名称: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, cyclohexylmethyl 2-formylphenyl hydrogen (S)-phosphate 著者 Lange, G, Loenze, P, Liesum, A. 登録日 2003-06-15 公開日 2004-02-17 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors. J.Med.Chem., 46, 2003

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