4MNY
 
 | | Crystal structure of urokinase-type plasminogen activator (uPA) complexed with bicyclic peptide UK903 | | 分子名称: | ACETATE ION, GLYCEROL, N,N',N''-benzene-1,3,5-triyltris(2-bromoacetamide), ... | | 著者 | Chen, S, Pojer, F, Heinis, C. | | 登録日 | 2013-09-11 | | 公開日 | 2014-02-05 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Peptide ligands stabilized by small molecules.
Angew.Chem.Int.Ed.Engl., 53, 2014
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7S7L
 | | Complex of tissue inhibitor of metalloproteinases-1 (TIMP-1) mutant (L34G/M66S/E67Y/L133N/S155L) with matrix metalloproteinase-3 catalytic domain (MMP-3cd) | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, CALCIUM ION, ... | | 著者 | Coban, M, Raeeszadeh-Sarmazdeh, M, Hockla, A, Sankaran, B, Radisky, E.S. | | 登録日 | 2021-09-16 | | 公開日 | 2022-03-16 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | Engineering of tissue inhibitor of metalloproteinases TIMP-1 for fine discrimination between closely related stromelysins MMP-3 and MMP-10.
J.Biol.Chem., 298, 2022
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7S7M
 | | Complex of tissue inhibitor of metalloproteinases-1 (TIMP-1) mutant (L34G/M66D/T98G/P131S/Q153N) with matrix metalloproteinase-3 catalytic domain (MMP-3cd) | | 分子名称: | CALCIUM ION, Metalloproteinase inhibitor 1, Stromelysin-1, ... | | 著者 | Coban, M, Raeeszadeh-Sarmazdeh, M, Sankaran, B, Hockla, A, Radisky, E.S. | | 登録日 | 2021-09-16 | | 公開日 | 2022-03-16 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Engineering of tissue inhibitor of metalloproteinases TIMP-1 for fine discrimination between closely related stromelysins MMP-3 and MMP-10.
J.Biol.Chem., 298, 2022
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2Y70
 | | CRYSTALLOGRAPHIC STRUCTURE OF GM23, MUTANT G89D, AN EXAMPLE OF CATALYTIC MIGRATION FROM TIM TO THIAMIN PHOSPHATE SYNTHASE. | | 分子名称: | ACETATE ION, SULFATE ION, TRIOSE-PHOSPHATE ISOMERASE | | 著者 | Saab-Rincon, G, Olvera, L, Olvera, M, Rudino-Pinera, E, Soberon, X, Morett, E. | | 登録日 | 2011-01-27 | | 公開日 | 2011-12-07 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Evolutionary Walk between (Beta/Alpha)(8) Barrels: Catalytic Migration from Triosephosphate Isomerase to Thiamin Phosphate Synthase.
J.Mol.Biol., 416, 2012
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2Y6Z
 | | Crystallographic structure of GM23 an example of Catalytic migration from TIM to thiamin phosphate synthase. | | 分子名称: | PYROPHOSPHATE 2-, THIAMIN PHOSPHATE, TRIOSE-PHOSPHATE ISOMERASE | | 著者 | Saab-Rincon, G, Olvera, L, Olvera, M, Rudino-Pinera, E, Soberon, X, Morett, E. | | 登録日 | 2011-01-27 | | 公開日 | 2011-12-07 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Evolutionary Walk between (Beta/Alpha)(8) Barrels: Catalytic Migration from Triosephosphate Isomerase to Thiamin Phosphate Synthase.
J.Mol.Biol., 416, 2012
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8PN7
 | | Engineered glycolyl-CoA carboxylase (G20R variant) with bound CoA | | 分子名称: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, COENZYME A, Propionyl-CoA carboxylase alpha subunit, ... | | 著者 | Zarzycki, J, Marchal, D.G, Schulz, L, Prinz, S, Erb, T.J. | | 登録日 | 2023-06-30 | | 公開日 | 2023-11-29 | | 最終更新日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (2.03 Å) | | 主引用文献 | Machine Learning-Supported Enzyme Engineering toward Improved CO 2 -Fixation of Glycolyl-CoA Carboxylase.
Acs Synth Biol, 12, 2023
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8PN8
 | | Engineered glycolyl-CoA carboxylase (L100N variant) with bound CoA | | 分子名称: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, COENZYME A, Propionyl-CoA carboxylase alpha subunit, ... | | 著者 | Zarzycki, J, Marchal, D.G, Schulz, L, Prinz, S, Erb, T.J. | | 登録日 | 2023-06-30 | | 公開日 | 2023-11-29 | | 最終更新日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (2.31 Å) | | 主引用文献 | Machine Learning-Supported Enzyme Engineering toward Improved CO 2 -Fixation of Glycolyl-CoA Carboxylase.
Acs Synth Biol, 12, 2023
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5OD1
 | | Structure of the engineered metalloesterase MID1sc10 complexed with a phosphonate transition state analogue | | 分子名称: | GLYCEROL, MID1sc10, ZINC ION, ... | | 著者 | Mittl, P.R.E, Studer, S, Hansen, D.A, Hilvert, D. | | 登録日 | 2017-07-04 | | 公開日 | 2018-12-12 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | | 主引用文献 | Evolution of a highly active and enantiospecific metalloenzyme from short peptides.
Science, 362, 2018
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5OD9
 | | Structure of the engineered metalloesterase MID1sc9 | | 分子名称: | (2~{S})-2-phenylpropanoic acid, 1,2-ETHANEDIOL, CHLORIDE ION, ... | | 著者 | Studer, S, Mittl, P.R.E, Hilvert, D. | | 登録日 | 2017-07-05 | | 公開日 | 2018-12-12 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.13 Å) | | 主引用文献 | Evolution of a highly active and enantiospecific metalloenzyme from short peptides.
Science, 362, 2018
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7DMX
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7DNB
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3ZJK
 | | crystal structure of Ttb-gly F401S mutant | | 分子名称: | BETA GLYCOSIDASE, CHLORIDE ION, GLYCEROL | | 著者 | Teze, D, Tran, V, Tellier, C, Dion, M, Leroux, C, Roncza, J, Czjzek, M. | | 登録日 | 2013-01-18 | | 公開日 | 2013-02-13 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Semi-Rational Approach for Converting a Gh1 Beta-Glycosidase Into a Beta-Transglycosidase.
Protein Eng.Des.Sel., 27, 2014
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7DNA
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5UF6
 | | The 2.8 A Electron Microscopy Structure of Adeno-Associated Virus-DJ Bound by a Heparanoid Pentasaccharide | | 分子名称: | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranoside, capsid protein VP1 | | 著者 | Xie, Q, Spear, J.M, Noble, A.J, Sousa, D.R, Meyer, N.L, Davulcu, O, Zhang, F, Linhardt, R.J, Stagg, S.M, Chapman, M. | | 登録日 | 2017-01-03 | | 公開日 | 2017-05-24 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | The 2.8 angstrom Electron Microscopy Structure of Adeno-Associated Virus-DJ Bound by a Heparinoid Pentasaccharide.
Mol Ther Methods Clin Dev, 5, 2017
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8TNR
 | | Cryo-EM structure of DDB1dB:CRBN:PT-179:SD40, conformation 2 | | 分子名称: | 2-[(3S)-2,6-dioxopiperidin-3-yl]-5-(morpholin-4-yl)-1H-isoindole-1,3(2H)-dione, DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, ... | | 著者 | Roy Burman, S.S, Hunkeler, M, Fischer, E.S. | | 登録日 | 2023-08-02 | | 公開日 | 2024-03-13 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Continuous evolution of compact protein degradation tags regulated by selective molecular glues.
Science, 383, 2024
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8TNP
 | | Cryo-EM structure of DDB1dB:CRBN:Pomalidomide:SD40 | | 分子名称: | DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, Protein cereblon, ... | | 著者 | Roy Burman, S.S, Hunkeler, M, Fischer, E.S. | | 登録日 | 2023-08-02 | | 公開日 | 2024-03-13 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Continuous evolution of compact protein degradation tags regulated by selective molecular glues.
Science, 383, 2024
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8TNQ
 | | Cryo-EM structure of DDB1dB:CRBN:PT-179:SD40, conformation 1 | | 分子名称: | 2-[(3S)-2,6-dioxopiperidin-3-yl]-5-(morpholin-4-yl)-1H-isoindole-1,3(2H)-dione, DNA damage-binding protein 1, Maltose/maltodextrin-binding periplasmic protein,SD40, ... | | 著者 | Roy Burman, S.S, Hunkeler, M, Fischer, E.S. | | 登録日 | 2023-08-02 | | 公開日 | 2024-03-13 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (2.41 Å) | | 主引用文献 | Continuous evolution of compact protein degradation tags regulated by selective molecular glues.
Science, 383, 2024
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5EHT
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6Q7P
 | | Crystal structure of OE1.2 | | 分子名称: | 1,2-ETHANEDIOL, 1-PHENYLETHANONE, MAGNESIUM ION, ... | | 著者 | Levy, C.W. | | 登録日 | 2018-12-13 | | 公開日 | 2019-06-05 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Design and evolution of an enzyme with a non-canonical organocatalytic mechanism.
Nature, 570, 2019
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6Q7R
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6Q7O
 | | Crystal structure of OE1 | | 分子名称: | CALCIUM ION, OE1 | | 著者 | Levy, C.W. | | 登録日 | 2018-12-13 | | 公開日 | 2019-06-05 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Design and evolution of an enzyme with a non-canonical organocatalytic mechanism.
Nature, 570, 2019
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6Q7N
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6Q7Q
 | | Crystal structure of OE1.3 | | 分子名称: | OE1.3 | | 著者 | Levy, C.W. | | 登録日 | 2018-12-13 | | 公開日 | 2019-06-05 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Design and evolution of an enzyme with a non-canonical organocatalytic mechanism.
Nature, 570, 2019
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8APZ
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8AQ0
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