PDB: 41 件ウェブページステータス検索Chemie searchBIRD

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5MGU	Kinetic and Structural Changes in HsmtPheRS, Induced by Pathogenic Mutations in Human FARS2 分子名称: PHENYLALANINE, Phenylalanine--tRNA ligase, mitochondrial 著者 Kartvelishvili, E, Tworowski, D, Vernon, H, Chrzanowska-Lightowlers, Z, Moor, N, Wang, J, Wong, L.-J, Safro, M. 登録日 2016-11-22 公開日 2017-05-03 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Kinetic and structural changes in HsmtPheRS, induced by pathogenic mutations in human FARS2. Protein Sci., 26, 2017
5MGV	Kinetic and Structural Changes in HsmtPheRS, Induced by Pathogenic Mutations in Human FARS2 分子名称: Phenylalanine--tRNA ligase, mitochondrial 著者 Kartvelishvili, E, Tworowski, D, Vernon, H, Chrzanowska-Lightowlers, Z, Moor, N, Wang, J, Wong, L.-J, Safro, M. 登録日 2016-11-22 公開日 2017-05-03 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Kinetic and structural changes in HsmtPheRS, induced by pathogenic mutations in human FARS2. Protein Sci., 26, 2017
5MGW	Kinetic and Structural Changes in HsmtPheRS, Induced by Pathogenic Mutations in Human FARS2 分子名称: PHENYLALANINE, Phenylalanine--tRNA ligase, mitochondrial 著者 Kartvelishvili, E, Tworowski, D, Vernon, H, Chrzanowska-Lightowlers, Z, Moor, N, Wang, J, Wong, L.-J, Safro, M. 登録日 2016-11-22 公開日 2017-05-03 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 Kinetic and structural changes in HsmtPheRS, induced by pathogenic mutations in human FARS2. Protein Sci., 26, 2017
6OZ5	Escherichia coli tRNA synthetase in complex with compound 3 分子名称: 1,2-ETHANEDIOL, 2-({[(2S)-1-cyclohexylpropan-2-yl]amino}methyl)phenol, DI(HYDROXYETHYL)ETHER, ... 著者 Kahne, D, Baidin, V, Owens, T.W. 登録日 2019-05-15 公開日 2020-11-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Simple Secondary Amines Inhibit Growth of Gram-Negative Bacteria through Highly Selective Binding to Phenylalanyl-tRNA Synthetase. J.Am.Chem.Soc., 143, 2021
6P24	Escherichia coli tRNA synthetase 分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... 著者 Kahne, D, Baidin, V, Owens, T.W. 登録日 2019-05-20 公開日 2020-11-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Simple Secondary Amines Inhibit Growth of Gram-Negative Bacteria through Highly Selective Binding to Phenylalanyl-tRNA Synthetase. J.Am.Chem.Soc., 143, 2021
6P26	Escherichia coli tRNA synthetase in complex with compound 1 分子名称: N-benzyl-2-(cyclohex-1-en-1-yl)ethan-1-amine, Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit 著者 Kahne, D, Baidin, V, Owens, T.W. 登録日 2019-05-21 公開日 2020-11-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.16 Å) 主引用文献 Simple Secondary Amines Inhibit Growth of Gram-Negative Bacteria through Highly Selective Binding to Phenylalanyl-tRNA Synthetase. J.Am.Chem.Soc., 143, 2021
6P8T	Acinetobacter baumannii tRNA synthetase in complex with compound 1 分子名称: MAGNESIUM ION, N-benzyl-2-(cyclohex-1-en-1-yl)ethan-1-amine, Phenylalanine--tRNA ligase alpha subunit, ... 著者 Kahne, D, Baidin, V, Owens, T.W. 登録日 2019-06-07 公開日 2020-11-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Simple Secondary Amines Inhibit Growth of Gram-Negative Bacteria through Highly Selective Binding to Phenylalanyl-tRNA Synthetase. J.Am.Chem.Soc., 143, 2021
7DAW	Crystal structure of Mycobacterium tuberculosis phenylalanyl-tRNA synthetase 分子名称: Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit, SULFATE ION 著者 Xu, M, Zhang, X, Xu, L, Chen, S. 登録日 2020-10-18 公開日 2021-01-13 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.83 Å) 主引用文献 Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis . J.Biol.Chem., 2021
7DB7	Crystal structure of Mycobacterium tuberculosis phenylalanyl-tRNA synthetase in complex with compound GDI05-001 分子名称: 1-[3-[2-(1H-indol-3-yl)ethylsulfamoyl]phenyl]-3-(1,3-thiazol-2-yl)urea, Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit, ... 著者 Xu, M, Zhang, X, Xu, L, Chen, S. 登録日 2020-10-19 公開日 2021-01-13 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.71 Å) 主引用文献 Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis . J.Biol.Chem., 2021
7DB8	Crystal structure of Mycobacterium tuberculosis phenylalanyl-tRNA synthetase in complex with compound PF-3845 分子名称: N-pyridin-3-yl-4-[[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methyl]piperidine-1-carboxamide, Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit, ... 著者 Xu, M, Zhang, X, Xu, L, Chen, S. 登録日 2020-10-19 公開日 2021-01-13 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis . J.Biol.Chem., 2021
7K98	Preaminoacylation complex of M. tuberculosis PheRS with cognate precursor tRNA and 5'-O-(N-phenylalanyl)sulfamoyl-adenosine (F-AMS) 分子名称: 5'-O-(L-phenylalanylsulfamoyl)adenosine, CHLORIDE ION, GLYCEROL, ... 著者 Michalska, K, Chang, C, Jedrzejczak, R, Wower, J, Baragana, B, Forte, B, Gilbert, I.H, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2020-09-28 公開日 2021-05-12 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 Mycobacterium tuberculosis Phe-tRNA synthetase: structural insights into tRNA recognition and aminoacylation. Nucleic Acids Res., 49, 2021
7K9M	Crystal structure of the complex of M. tuberculosis PheRS with cognate precursor tRNA and 5'-O-(N-phenylalanyl)sulfamoyl-adenosine 分子名称: 5'-O-(L-phenylalanylsulfamoyl)adenosine, GLYCEROL, HEXAETHYLENE GLYCOL, ... 著者 Michalska, K, Chang, C, Jedrzejczak, R, Wower, J, Baragana, B, Forte, B, Gilbert, I.H, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2020-09-29 公開日 2021-05-12 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Mycobacterium tuberculosis Phe-tRNA synthetase: structural insights into tRNA recognition and aminoacylation. Nucleic Acids Res., 49, 2021
7KA0	Crystal structure of the complex of M. tuberculosis PheRS with cognate precursor tRNA and phenylalanine 分子名称: ACETATE ION, GLYCEROL, MAGNESIUM ION, ... 著者 Chang, C, Michalska, K, Jedrzejczak, R, Wower, J, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2020-09-29 公開日 2021-05-12 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Mycobacterium tuberculosis Phe-tRNA synthetase: structural insights into tRNA recognition and aminoacylation. Nucleic Acids Res., 49, 2021
7KAB	M. tuberculosis PheRS complex with cognate precursor tRNA and phenylalanine 分子名称: GLYCEROL, MAGNESIUM ION, PHENYLALANINE, ... 著者 Chang, C, Michalska, K, Jedrzejczak, R, Wower, J, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2020-09-30 公開日 2021-05-12 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Mycobacterium tuberculosis Phe-tRNA synthetase: structural insights into tRNA recognition and aminoacylation. Nucleic Acids Res., 49, 2021
7N8Y	Oxidized PheRS G318W from Salmonella enterica serovar Typhimurium 分子名称: Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit 著者 Srinivas, P, Dunham, C.M. 登録日 2021-06-16 公開日 2021-10-06 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.65 Å) 主引用文献 Oxidation alters the architecture of the phenylalanyl-tRNA synthetase editing domain to confer hyperaccuracy. Nucleic Acids Res., 49, 2021
8P8X	Crystal structure of a pathogenic mutant variant of human mitochodnrial PheRS 分子名称: PHENYLALANINE, Phenylalanine--tRNA ligase, mitochondrial 著者 Chen, W, Kuhle, B. 登録日 2023-06-03 公開日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 Clinical and molecular characterization of novel FARS2 variants causing neonatal mitochondrial disease. Mol.Genet.Metab., 140, 2023

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