6P8T

Acinetobacter baumannii tRNA synthetase in complex with compound 1

Summary for 6P8T

• Entry DOI: 10.2210/pdb6p8t/pdb
• Descriptor: Phenylalanine--tRNA ligase beta subunit, Phenylalanine--tRNA ligase alpha subunit, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: inhibitor, aminoacyl-trna synthetase, phers, antibacterial, ligase
• Biological source: Acinetobacter baumannii (strain ATCC 19606 / DSM 30007 / CIP 70.34 / JCM 6841 / NBRC 109757 / NCIMB 12457 / NCTC 12156 / 81); More
• Total number of polymer chains: 8
• Total formula weight: 500977.78

Authors

Kahne, D.,Baidin, V.,Owens, T.W. (deposition date: 2019-06-07, release date: 2020-11-18, Last modification date: 2023-10-11)

• Primary citation: Baidin, V.,Owens, T.W.,Lazarus, M.B.,Kahne, D.; Simple Secondary Amines Inhibit Growth of Gram-Negative Bacteria through Highly Selective Binding to Phenylalanyl-tRNA Synthetase.; J.Am.Chem.Soc., 143:623-627, 2021; PubMed: 33411531; DOI: 10.1021/jacs.0c11113

Experimental method

X-RAY DIFFRACTION (3.15 Å)