6P24

Escherichia coli tRNA synthetase

Summary for 6P24

Entry DOI	10.2210/pdb6p24/pdb
Descriptor	Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit, MAGNESIUM ION, ... (10 entities in total)
Functional Keywords	inhibitor, aminoacyl-trna synthetase, phers, antibacterial, ligase
Biological source	Escherichia coli (strain K12) More
Total number of polymer chains	4
Total formula weight	253449.95
Authors	Kahne, D.,Baidin, V.,Owens, T.W. (deposition date: 2019-05-20, release date: 2020-11-18, Last modification date: 2023-10-11)
Primary citation	Baidin, V.,Owens, T.W.,Lazarus, M.B.,Kahne, D. Simple Secondary Amines Inhibit Growth of Gram-Negative Bacteria through Highly Selective Binding to Phenylalanyl-tRNA Synthetase. J.Am.Chem.Soc., 143:623-627, 2021 Cited by PubMed: 33411531 DOI: 10.1021/jacs.0c11113 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.12 Å)

Structure validation