6P24
Escherichia coli tRNA synthetase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004826 | molecular_function | phenylalanine-tRNA ligase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006412 | biological_process | translation |
| A | 0006432 | biological_process | phenylalanyl-tRNA aminoacylation |
| A | 0009328 | cellular_component | phenylalanine-tRNA ligase complex |
| A | 0043039 | biological_process | tRNA aminoacylation |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000049 | molecular_function | tRNA binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004826 | molecular_function | phenylalanine-tRNA ligase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006412 | biological_process | translation |
| B | 0006432 | biological_process | phenylalanyl-tRNA aminoacylation |
| B | 0009328 | cellular_component | phenylalanine-tRNA ligase complex |
| B | 0016020 | cellular_component | membrane |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000049 | molecular_function | tRNA binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| C | 0004826 | molecular_function | phenylalanine-tRNA ligase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006412 | biological_process | translation |
| C | 0006432 | biological_process | phenylalanyl-tRNA aminoacylation |
| C | 0009328 | cellular_component | phenylalanine-tRNA ligase complex |
| C | 0043039 | biological_process | tRNA aminoacylation |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000049 | molecular_function | tRNA binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0003723 | molecular_function | RNA binding |
| D | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| D | 0004826 | molecular_function | phenylalanine-tRNA ligase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006412 | biological_process | translation |
| D | 0006432 | biological_process | phenylalanyl-tRNA aminoacylation |
| D | 0009328 | cellular_component | phenylalanine-tRNA ligase complex |
| D | 0016020 | cellular_component | membrane |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue MG A 401 |
| Chain | Residue |
| A | GLU252 |
| B | GLU463 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue MG A 402 |
| Chain | Residue |
| A | ILE101 |
| A | GLU102 |
| A | ASN103 |
| A | HOH516 |
| B | ASN503 |
| B | ASP504 |
| D | LYS505 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue MG A 403 |
| Chain | Residue |
| A | GLU256 |
| A | GLU268 |
| B | GLU31 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue MG A 404 |
| Chain | Residue |
| A | GLY308 |
| A | THR310 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue MG A 405 |
| Chain | Residue |
| A | LYS327 |
| D | LEU627 |
| D | HOH933 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 406 |
| Chain | Residue |
| A | LYS262 |
| A | ASN263 |
| A | LEU267 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue HEZ A 407 |
| Chain | Residue |
| A | GLN208 |
| A | PHE250 |
| A | GLY271 |
| A | PHE295 |
| A | GLY296 |
| A | MET297 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue TRS A 408 |
| Chain | Residue |
| A | GLY104 |
| A | LEU106 |
| A | LYS327 |
| B | ASN503 |
| D | ARG497 |
| D | LEU627 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue PEG A 409 |
| Chain | Residue |
| A | ASP215 |
| A | THR216 |
| B | GLN480 |
| D | GLN480 |
| site_id | AD1 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 410 |
| Chain | Residue |
| A | GLU237 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue TRS A 411 |
| Chain | Residue |
| A | PRO97 |
| A | ARG100 |
| D | GLU622 |
| site_id | AD3 |
| Number of Residues | 1 |
| Details | binding site for residue MG B 801 |
| Chain | Residue |
| B | GLU31 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 802 |
| Chain | Residue |
| A | HOH518 |
| A | HOH545 |
| B | LEU416 |
| B | GLU459 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 803 |
| Chain | Residue |
| B | THR253 |
| B | ASN254 |
| B | MET264 |
| B | HOH929 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue MG B 804 |
| Chain | Residue |
| B | HIS488 |
| C | SER118 |
| site_id | AD7 |
| Number of Residues | 8 |
| Details | binding site for residue PEG B 805 |
| Chain | Residue |
| B | HIS265 |
| B | ILE304 |
| B | MET313 |
| B | GLY314 |
| B | GLY315 |
| B | ILE316 |
| B | GLU334 |
| B | HOH905 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for residue PGE B 806 |
| Chain | Residue |
| B | MET1 |
| B | LYS2 |
| B | VAL162 |
| B | CYS241 |
| B | ASP355 |
| B | HIS358 |
| B | ARG359 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 807 |
| Chain | Residue |
| B | ASP423 |
| B | GLU439 |
| B | GLY440 |
| B | ASP442 |
| B | GLU443 |
| B | TRP444 |
| site_id | AE1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 808 |
| Chain | Residue |
| B | PRO401 |
| B | SER450 |
| B | PHE453 |
| site_id | AE2 |
| Number of Residues | 2 |
| Details | binding site for residue PEG B 809 |
| Chain | Residue |
| B | ALA554 |
| B | LEU673 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue PEG B 810 |
| Chain | Residue |
| B | PRO138 |
| B | TYR150 |
| B | LEU151 |
| B | TRP233 |
| site_id | AE4 |
| Number of Residues | 5 |
| Details | binding site for residue PEG B 811 |
| Chain | Residue |
| B | PRO190 |
| B | GLU191 |
| B | ILE192 |
| B | LYS371 |
| B | HOH933 |
| site_id | AE5 |
| Number of Residues | 6 |
| Details | binding site for residue PEG B 812 |
| Chain | Residue |
| B | ALA81 |
| B | LEU119 |
| B | GLU124 |
| B | HIS131 |
| B | GLY133 |
| B | HOH975 |
| site_id | AE6 |
| Number of Residues | 3 |
| Details | binding site for residue PGE B 813 |
| Chain | Residue |
| A | ARG321 |
| B | GLN563 |
| D | GLN763 |
| site_id | AE7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 814 |
| Chain | Residue |
| D | ASN739 |
| D | LEU740 |
| A | PRO97 |
| B | GLU603 |
| B | HIS604 |
| B | TRP605 |
| site_id | AE8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 815 |
| Chain | Residue |
| B | GLU439 |
| B | GLN445 |
| B | ASN606 |
| D | HEZ803 |
| site_id | AE9 |
| Number of Residues | 5 |
| Details | binding site for residue MG C 401 |
| Chain | Residue |
| C | GLU256 |
| C | GLU268 |
| C | EDO406 |
| C | HOH543 |
| D | GLU31 |
| site_id | AF1 |
| Number of Residues | 4 |
| Details | binding site for residue MG C 402 |
| Chain | Residue |
| C | GLU252 |
| D | ASP454 |
| D | ASP460 |
| D | GLU463 |
| site_id | AF2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 403 |
| Chain | Residue |
| B | TYR615 |
| C | ILE92 |
| C | ASP93 |
| C | LEU96 |
| site_id | AF3 |
| Number of Residues | 6 |
| Details | binding site for residue PEG C 404 |
| Chain | Residue |
| B | ARG497 |
| B | ARG692 |
| B | HOH951 |
| C | GLY104 |
| C | LYS327 |
| D | ASN503 |
| site_id | AF4 |
| Number of Residues | 2 |
| Details | binding site for residue PEG C 405 |
| Chain | Residue |
| C | ASN144 |
| C | HIS276 |
| site_id | AF5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO C 406 |
| Chain | Residue |
| C | TYR247 |
| C | GLU256 |
| C | MG401 |
| C | HOH533 |
| D | GLU31 |
| site_id | AF6 |
| Number of Residues | 7 |
| Details | binding site for residue TRS C 407 |
| Chain | Residue |
| C | GLY124 |
| C | THR126 |
| C | GLN181 |
| C | PRO184 |
| C | ILE185 |
| C | ARG186 |
| C | ILE187 |
| site_id | AF7 |
| Number of Residues | 2 |
| Details | binding site for residue EDO C 408 |
| Chain | Residue |
| C | ARG192 |
| D | SER572 |
| site_id | AF8 |
| Number of Residues | 4 |
| Details | binding site for residue MG D 801 |
| Chain | Residue |
| D | ASP33 |
| D | GLU159 |
| D | ILE160 |
| D | SER161 |
| site_id | AF9 |
| Number of Residues | 2 |
| Details | binding site for residue MG D 802 |
| Chain | Residue |
| D | ASN687 |
| D | ASP691 |
| site_id | AG1 |
| Number of Residues | 6 |
| Details | binding site for residue HEZ D 803 |
| Chain | Residue |
| A | ILE92 |
| A | ASP93 |
| A | LEU96 |
| B | EDO815 |
| D | TYR615 |
| D | LYS754 |
| site_id | AG2 |
| Number of Residues | 5 |
| Details | binding site for residue HEZ D 804 |
| Chain | Residue |
| D | MET27 |
| D | GLY470 |
| D | TYR471 |
| D | ASN472 |
| D | ASN473 |
| site_id | AG3 |
| Number of Residues | 8 |
| Details | binding site for residue HEZ D 805 |
| Chain | Residue |
| D | TRP7 |
| D | GLU10 |
| D | TRP11 |
| D | LYS237 |
| D | TYR255 |
| D | GLU259 |
| D | ARG375 |
| D | HOH1098 |
| site_id | AG4 |
| Number of Residues | 4 |
| Details | binding site for residue HEZ D 806 |
| Chain | Residue |
| D | TYR150 |
| D | LEU151 |
| D | LEU232 |
| D | TRP233 |
| site_id | AG5 |
| Number of Residues | 3 |
| Details | binding site for residue TRS D 807 |
| Chain | Residue |
| D | ASP200 |
| D | ASP201 |
| D | LYS222 |
| site_id | AG6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO D 808 |
| Chain | Residue |
| D | PRO366 |
| D | SER450 |
| D | ARG452 |
| D | PHE453 |
| D | HOH934 |
| D | HOH982 |
| site_id | AG7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 809 |
| Chain | Residue |
| D | PHE122 |
| D | SER128 |
| D | LYS235 |
| D | GLU236 |
| site_id | AG8 |
| Number of Residues | 2 |
| Details | binding site for residue EDO D 810 |
| Chain | Residue |
| D | HIS525 |
| D | GLU683 |
| site_id | AG9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 811 |
| Chain | Residue |
| C | GLU102 |
| D | GLY506 |
| D | ARG568 |
| site_id | AH1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 812 |
| Chain | Residue |
| D | PRO704 |
| D | ASN706 |
| D | THR768 |
| D | LEU769 |
| site_id | AH2 |
| Number of Residues | 5 |
| Details | binding site for residue PEG D 813 |
| Chain | Residue |
| D | HIS265 |
| D | ILE304 |
| D | MET313 |
| D | GLY315 |
| D | GLU334 |
| site_id | AH3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO D 814 |
| Chain | Residue |
| B | LEU110 |
| B | ARG111 |
| D | ASP291 |
| D | GLY351 |
| D | HOH944 |
| D | HOH1021 |
| site_id | AH4 |
| Number of Residues | 3 |
| Details | binding site for residue PEG D 815 |
| Chain | Residue |
| D | LYS728 |
| D | VAL736 |
| D | VAL738 |
| site_id | AH5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 816 |
| Chain | Residue |
| D | LYS235 |
| D | SER245 |
| D | ILE246 |
| site_id | AH6 |
| Number of Residues | 2 |
| Details | binding site for residue EDO D 817 |
| Chain | Residue |
| D | ARG279 |
| D | ASP306 |
| site_id | AH7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO D 818 |
| Chain | Residue |
| B | PHE741 |
| B | ASP742 |
| D | HIS604 |
| D | TRP605 |
| D | ASN606 |
| D | LEU607 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| D | GLU463 | |
| D | GLU464 | |
| B | GLU464 | |
| D | ASP454 | |
| D | ASP460 | |
| B | ASP454 | |
| B | ASP460 | |
| B | GLU463 |
