7DB7

Crystal structure of Mycobacterium tuberculosis phenylalanyl-tRNA synthetase in complex with compound GDI05-001

Summary for 7DB7

• Entry DOI: 10.2210/pdb7db7/pdb
• Related: 7DAW
• Descriptor: Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit, 1-[3-[2-(1H-indol-3-yl)ethylsulfamoyl]phenyl]-3-(1,3-thiazol-2-yl)urea, ... (5 entities in total)
• Functional Keywords: aminoacylation, trna-binding, aminoacyl-trna synthetase, atp-binding, ligase
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv); More
• Total number of polymer chains: 2
• Total formula weight: 129189.35

Authors

Xu, M.,Zhang, X.,Xu, L.,Chen, S. (deposition date: 2020-10-19, release date: 2021-01-13, Last modification date: 2023-11-29)

• Primary citation: Wang, H.,Xu, M.,Engelhart, C.A.,Zhang, X.,Yan, B.,Pan, M.,Xu, Y.,Fan, S.,Liu, R.,Xu, L.,Hua, L.,Schnappinger, D.,Chen, S.; Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis .; J.Biol.Chem., 2021; PubMed: 33397709; DOI: 10.1074/jbc.RA120.016477

Experimental method

X-RAY DIFFRACTION (2.71 Å)