7DB7
Crystal structure of Mycobacterium tuberculosis phenylalanyl-tRNA synthetase in complex with compound GDI05-001
Summary for 7DB7
Entry DOI | 10.2210/pdb7db7/pdb |
Related | 7DAW |
Descriptor | Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit, 1-[3-[2-(1H-indol-3-yl)ethylsulfamoyl]phenyl]-3-(1,3-thiazol-2-yl)urea, ... (5 entities in total) |
Functional Keywords | aminoacylation, trna-binding, aminoacyl-trna synthetase, atp-binding, ligase |
Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) More |
Total number of polymer chains | 2 |
Total formula weight | 129189.35 |
Authors | |
Primary citation | Wang, H.,Xu, M.,Engelhart, C.A.,Zhang, X.,Yan, B.,Pan, M.,Xu, Y.,Fan, S.,Liu, R.,Xu, L.,Hua, L.,Schnappinger, D.,Chen, S. Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis . J.Biol.Chem., 2021 Cited by PubMed: 33397709DOI: 10.1074/jbc.RA120.016477 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.71 Å) |
Structure validation
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