6S7H
| Human CD73 (5'-nucleotidase) in complex with PSB12489 (an AOPCP derivative) in the closed state | 分子名称: | (N6,N6)-methyl,benzyl-C2-chloro-(alpha,beta)-methylene-ADP, 5'-nucleotidase, CALCIUM ION, ... | 著者 | Pippel, J, Strater, N. | 登録日 | 2019-07-04 | 公開日 | 2020-07-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | X-Ray Co-Crystal Structure Guides the Way to Subnanomolar Competitive Ecto-5'-Nucleotidase (CD73) Inhibitors for Cancer Immunotherapy Adv Ther, 2019
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4H2F
| Human ecto-5'-nucleotidase (CD73): crystal form I (open) in complex with adenosine | 分子名称: | 5'-nucleotidase, ADENOSINE, CALCIUM ION, ... | 著者 | Straeter, N, Knapp, K.M, Zebisch, M, Pippel, J. | 登録日 | 2012-09-12 | 公開日 | 2012-11-28 | 最終更新日 | 2014-10-08 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Crystal Structure of the Human Ecto-5'-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling. Structure, 20, 2012
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1HPU
| 5'-NUCLEOTIDASE (CLOSED FORM), COMPLEX WITH AMPCP | 分子名称: | 5'-NUCLEOTIDASE, MANGANESE (II) ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER | 著者 | Knoefel, T, Straeter, N. | 登録日 | 2000-12-13 | 公開日 | 2002-03-20 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Mechanism of hydrolysis of phosphate esters by the dimetal center of 5'-nucleotidase based on crystal structures. J.Mol.Biol., 309, 2001
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6Z9D
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3IVD
| Putative 5'-Nucleotidase (c4898) from Escherichia Coli in complex with Uridine | 分子名称: | CHLORIDE ION, FE (III) ION, MANGANESE (II) ION, ... | 著者 | Ramagopal, U.A, Toro, R, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | 登録日 | 2009-08-31 | 公開日 | 2009-09-29 | 最終更新日 | 2021-02-10 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Putative 5'-Nucleotidase (c4898) from Escherichia Coli in complex with Uridine To be Published
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5H7W
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6XUE
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6XUQ
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4Q7F
| 1.98 Angstrom Crystal Structure of Putative 5'-Nucleotidase from Staphylococcus aureus in complex with Adenosine. | 分子名称: | (2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-tetrahydro-2-(hydroxymethyl)furan-3-ol, 5' nucleotidase family protein, MAGNESIUM ION, ... | 著者 | Minasov, G, Nocadello, S, Shuvalova, L, Dubrovska, I, Winsor, J, Bagnoli, F, Falugi, F, Bottomley, M, Grandi, G, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2014-04-24 | 公開日 | 2014-05-07 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | 1.98 Angstrom Crystal Structure of Putative 5'-Nucleotidase from Staphylococcus aureus in complex with Adenosine. TO BE PUBLISHED
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4H2I
| Human ecto-5'-nucleotidase (CD73): crystal form III (closed) in complex with AMPCP | 分子名称: | 5'-nucleotidase, CALCIUM ION, CHLORIDE ION, ... | 著者 | Straeter, N, Knapp, K.M, Zebisch, M, Pippel, J. | 登録日 | 2012-09-12 | 公開日 | 2012-11-28 | 最終更新日 | 2018-06-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structure of the Human Ecto-5'-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling. Structure, 20, 2012
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6TWA
| Human CD73 (ecto 5'-nucleotidase) in complex with PSB12646 (an AOPCP derivative, compound 20 in publication) in the closed state | 分子名称: | 5'-nucleotidase, CALCIUM ION, ZINC ION, ... | 著者 | Pippel, J, Strater, N. | 登録日 | 2020-01-12 | 公開日 | 2020-02-19 | 最終更新日 | 2020-04-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | 2-Substituted alpha , beta-Methylene-ADP Derivatives: Potent Competitive Ecto-5'-nucleotidase (CD73) Inhibitors with Variable Binding Modes. J.Med.Chem., 63, 2020
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3ZU0
| Structure of Haemophilus influenzae NAD nucleotidase (NadN) | 分子名称: | NAD NUCLEOTIDASE, PHOSPHATE ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... | 著者 | Garavaglia, S, Bruzzone, S, Cassani, C, Canella, L, Allegrone, G, Sturla, L, Mannino, E, Millo, E, De Flora, A, Rizzi, M. | 登録日 | 2011-07-13 | 公開日 | 2011-12-14 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.001 Å) | 主引用文献 | The High-Resolution Crystal Structure of Periplasmic Haemophilus Influenzae Nad Nucleotidase Reveals a Novel Enzymatic Function of Human Cd73 Related to Nad Metabolism. Biochem.J., 441, 2012
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6S7F
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3QFK
| 2.05 Angstrom Crystal Structure of Putative 5'-Nucleotidase from Staphylococcus aureus in complex with alpha-ketoglutarate | 分子名称: | 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, DI(HYDROXYETHYL)ETHER, ... | 著者 | Minasov, G, Wawrzak, Z, Krishna, S.N, Halavaty, A, Shuvalova, L, Dubrovska, I, Winsor, J, Kiryukhina, O, Bagnoli, F, Falugi, F, Bottomley, M, Grandi, G, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2011-01-21 | 公開日 | 2011-02-09 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | 2.05 Angstrom Crystal Structure of Putative 5'-Nucleotidase from Staphylococcus aureus in complex with alpha-ketoglutarate. TO BE PUBLISHED
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2WDF
| Termus thermophilus Sulfate thiohydrolase SoxB | 分子名称: | MANGANESE (II) ION, SULFUR OXIDATION PROTEIN SOXB, TERTIARY-BUTYL ALCOHOL | 著者 | Sauve, V, Roversi, P, Leath, K.J, Garman, E.F, Antrobus, R, Lea, S.M, Berks, B.C. | 登録日 | 2009-03-24 | 公開日 | 2009-06-16 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Mechanism for the Hydrolysis of a Sulfur-Sulfur Bond Based on the Crystal Structure of the Thiosulfohydrolase Soxb. J.Biol.Chem., 284, 2009
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6XUG
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1OI8
| 5'-Nucleotidase (E. coli) with an Engineered Disulfide Bridge (P90C, L424C) | 分子名称: | CARBONATE ION, MANGANESE (II) ION, PROTEIN USHA, ... | 著者 | Schultz-Heienbrok, R, Maier, T, Straeter, N. | 登録日 | 2003-06-10 | 公開日 | 2004-06-10 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Trapping a 96 Degree Domain Rotation in Two Distinct Conformations by Engineered Disulfide Bridges Protein Sci., 13, 2004
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1OID
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1HO5
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6Z9B
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7D0V
| Crystal structure of Taiwan cobra 5'-nucleotidase | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Snake venom 5'-nucleotidase, ... | 著者 | Tsai, M.-H, Lin, I.-J, Lin, C.-C, Wu, W.-G. | 登録日 | 2020-09-12 | 公開日 | 2021-09-15 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.175 Å) | 主引用文献 | Crystal structure of Taiwan cobra 5'-nucleotidase To Be Published
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4H1S
| Crystal Structure of a Truncated Soluble form of Human CD73 with Ecto-5'-Nucleotidase activity | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5'-nucleotidase, PHOSPHATE ION, ... | 著者 | Heuts, D.P, Weissenborn, M.J, Olkhov, R.V, Shaw, A.M, Levy, C.W, Scrutton, N.S. | 登録日 | 2012-09-11 | 公開日 | 2012-10-03 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of a soluble form of human CD73 with ecto-5'-nucleotidase activity. Chembiochem, 13, 2012
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7QGO
| Human CD73 (ecto 5'-nucleotidase) in complex with MRS4602 (a 3-methyl-CMPCP derivative, compound 21 in paper) in the closed state (crystal form III) | 分子名称: | 5'-nucleotidase, ZINC ION, [[(2~{R},3~{S},4~{R},5~{R})-5-[(4~{E})-4-[(4-methoxycarbonylphenyl)methoxyimino]-3-methyl-2-oxidanylidene-pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]methylphosphonic acid | 著者 | Strater, N. | 登録日 | 2021-12-09 | 公開日 | 2022-02-16 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.206 Å) | 主引用文献 | Structure-Activity Relationship of 3-Methylcytidine-5'-alpha , beta-methylenediphosphates as CD73 Inhibitors. J.Med.Chem., 65, 2022
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2USH
| 5'-NUCLEOTIDASE FROM E. COLI | 分子名称: | 5'-NUCLEOTIDASE, TUNGSTATE(VI)ION, ZINC ION | 著者 | Knofel, T, Strater, N. | 登録日 | 1998-09-24 | 公開日 | 1999-06-15 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | X-ray structure of the Escherichia coli periplasmic 5'-nucleotidase containing a dimetal catalytic site. Nat.Struct.Biol., 6, 1999
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4WWL
| E. coli 5'-nucleotidase mutant I521C labeled with MTSL (intermediate form) | 分子名称: | CARBONATE ION, GLYCEROL, Protein UshA, ... | 著者 | Krug, U, Paithankar, K.S, Schultz-Heienbrok, R, Strater, N. | 登録日 | 2014-11-11 | 公開日 | 2014-11-26 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | E. coli 5'-nucleotidase mutant I521C labeled with MTSL (intermediate form) To Be Published
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