6S7H

Human CD73 (5'-nucleotidase) in complex with PSB12489 (an AOPCP derivative) in the closed state

Summary for 6S7H

Entry DOI	10.2210/pdb6s7h/pdb
Descriptor	5'-nucleotidase, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywords	nucleotide analog, en, 5nt, inhibitor, complex, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	60025.15
Authors	Pippel, J.,Strater, N. (deposition date: 2019-07-04, release date: 2020-07-22, Last modification date: 2024-01-24)
Primary citation	Bhattarai, S.,Pippel, J.,Meyer, A.,Freundlieb, M.,Schmies, C.,Abdelrahman, A.,Fiene, A.,Lee, S.Y.,Zimmermann, H.,El-Tayeb, A.,Yegutkin, G.G.,Strater, N.,Muller, C.E. X-Ray Co-Crystal Structure Guides the Way to Subnanomolar Competitive Ecto-5'-Nucleotidase (CD73) Inhibitors for Cancer Immunotherapy Adv Ther, 2019 Cited by DOI: 10.1002/adtp.201900075 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation