6S7H
Human CD73 (5'-nucleotidase) in complex with PSB12489 (an AOPCP derivative) in the closed state
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0002953 | molecular_function | 5'-deoxynucleotidase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0006196 | biological_process | AMP catabolic process |
A | 0006259 | biological_process | DNA metabolic process |
A | 0007159 | biological_process | leukocyte cell-cell adhesion |
A | 0008252 | molecular_function | nucleotidase activity |
A | 0008253 | molecular_function | 5'-nucleotidase activity |
A | 0008270 | molecular_function | zinc ion binding |
A | 0009166 | biological_process | nucleotide catabolic process |
A | 0009897 | cellular_component | external side of plasma membrane |
A | 0009986 | cellular_component | cell surface |
A | 0010035 | biological_process | obsolete response to inorganic substance |
A | 0016020 | cellular_component | membrane |
A | 0016787 | molecular_function | hydrolase activity |
A | 0016788 | molecular_function | hydrolase activity, acting on ester bonds |
A | 0033198 | biological_process | response to ATP |
A | 0042802 | molecular_function | identical protein binding |
A | 0046032 | biological_process | ADP catabolic process |
A | 0046034 | biological_process | ATP metabolic process |
A | 0046086 | biological_process | adenosine biosynthetic process |
A | 0046872 | molecular_function | metal ion binding |
A | 0050340 | molecular_function | thymidylate 5'-phosphatase activity |
A | 0050483 | molecular_function | IMP 5'-nucleotidase activity |
A | 0050484 | molecular_function | GMP 5'-nucleotidase activity |
A | 0050728 | biological_process | negative regulation of inflammatory response |
A | 0055074 | biological_process | calcium ion homeostasis |
A | 0070062 | cellular_component | extracellular exosome |
A | 0098552 | cellular_component | side of membrane |
A | 0106411 | molecular_function | XMP 5'-nucleosidase activity |
A | 0110148 | biological_process | obsolete biomineralization |
A | 0140928 | biological_process | inhibition of non-skeletal tissue mineralization |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | binding site for residue ZN A 601 |
Chain | Residue |
A | ASP36 |
A | HIS38 |
A | ASP85 |
A | KYW604 |
A | HOH732 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue ZN A 602 |
Chain | Residue |
A | KYW604 |
A | ASP85 |
A | ASN117 |
A | HIS220 |
A | HIS243 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue CA A 603 |
Chain | Residue |
A | ASN213 |
A | ASP237 |
A | GLY298 |
A | HOH713 |
A | HOH843 |
site_id | AC4 |
Number of Residues | 25 |
Details | binding site for residue KYW A 604 |
Chain | Residue |
A | HIS38 |
A | ASP85 |
A | ASN117 |
A | HIS118 |
A | LEU184 |
A | SER185 |
A | HIS243 |
A | ASN245 |
A | ARG354 |
A | ASN390 |
A | GLY392 |
A | GLY393 |
A | ARG395 |
A | PHE417 |
A | GLY447 |
A | PHE500 |
A | ASP506 |
A | ZN601 |
A | ZN602 |
A | HOH720 |
A | HOH732 |
A | HOH762 |
A | HOH788 |
A | HOH794 |
A | HOH835 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22997138, ECO:0000269|PubMed:23142347, ECO:0000269|PubMed:34403084, ECO:0007744|PDB:4H1S, ECO:0007744|PDB:7P9N |
Chain | Residue | Details |
A | ASP36 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22997138, ECO:0000269|PubMed:23142347, ECO:0000269|PubMed:34403084, ECO:0007744|PDB:4H1S, ECO:0007744|PDB:4H1Y, ECO:0007744|PDB:4H2B, ECO:0007744|PDB:4H2G, ECO:0007744|PDB:4H2I, ECO:0007744|PDB:7P9N |
Chain | Residue | Details |
A | HIS38 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22997138, ECO:0000269|PubMed:23142347, ECO:0000269|PubMed:34403084, ECO:0007744|PDB:4H1S, ECO:0007744|PDB:4H1Y, ECO:0007744|PDB:4H2B, ECO:0007744|PDB:4H2F, ECO:0007744|PDB:4H2G, ECO:0007744|PDB:4H2I, ECO:0007744|PDB:7P9N |
Chain | Residue | Details |
A | ASP85 | |
A | ASN117 | |
A | HIS220 | |
A | HIS243 |
site_id | SWS_FT_FI4 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:34403084, ECO:0007744|PDB:7PBA |
Chain | Residue | Details |
A | ARG354 | |
A | ASN390 | |
A | ARG395 | |
A | PHE417 | |
A | PHE500 | |
A | ASP506 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | SITE: Transition state stabilizer => ECO:0000269|PubMed:23142347 |
Chain | Residue | Details |
A | HIS118 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | SITE: Transition state stabilizer => ECO:0000305|PubMed:23142347 |
Chain | Residue | Details |
A | ASP121 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | LIPID: GPI-anchor amidated serine => ECO:0000269|PubMed:2129526 |
Chain | Residue | Details |
A | SER549 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASP53 |
site_id | SWS_FT_FI9 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:22997138, ECO:0000269|PubMed:23142347 |
Chain | Residue | Details |
A | ASP311 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973 |
Chain | Residue | Details |
A | ASP333 |
site_id | SWS_FT_FI11 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 |
Chain | Residue | Details |
A | ASP403 |