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7WTD
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Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the intermediate state 1
分子名称: ADENOSINE-5'-TRIPHOSPHATE, COENZYME A, Pyruvate carboxylase, ...
著者Chai, P, Lan, P, Wu, J, Lei, M.
登録日2022-02-04
公開日2022-11-09
最終更新日2022-11-16
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
Mol.Cell, 82, 2022
7WTC
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Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the ground state
分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ACETYL COENZYME *A, Pyruvate carboxylase, ...
著者Chai, P, Lan, P, Wu, J, Lei, M.
登録日2022-02-04
公開日2022-11-09
最終更新日2022-11-16
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
Mol.Cell, 82, 2022
7TA5
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BU of 7ta5 by Molmil
Crystal structure of cyanophycin synthetase 2 from Gloeothece citriformis
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BICINE, D(-)-TARTARIC ACID, ...
著者Sharon, I, Schmeing, T.M.
登録日2021-12-20
公開日2022-03-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure and Function of the beta-Asp-Arg Polymerase Cyanophycin Synthetase 2.
Acs Chem.Biol., 17, 2022
7KCT
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Crystal Structure of the Hydrogenobacter thermophilus 2-Oxoglutarate Carboxylase (OGC) Biotin Carboxylase (BC) Domain Dimer in Complex with Adenosine 5'-Diphosphate Magnesium Salt (MgADP), Adenosine 5'-Diphosphate (ADP, and Bicarbonate Anion (Hydrogen Carbonate/HCO3-)
分子名称: 2-oxoglutarate carboxylase small subunit, ADENOSINE-5'-DIPHOSPHATE, BICARBONATE ION, ...
著者Buhrman, G.K, Rose, R.B, Enriquez, P, Truong, V.
登録日2020-10-07
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Structure, Function, and Thermal Adaptation of the Biotin Carboxylase Domain Dimer from Hydrogenobacter thermophilus 2-Oxoglutarate Carboxylase.
Biochemistry, 60, 2021
7KC7
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Biotin Carboxylase domain of Thermophilic 2-Oxoglutarate Carboxylase bound to ADP without Magnesium with disordered phosphate tail
分子名称: 2-oxoglutarate carboxylase small subunit, ADENOSINE-5'-DIPHOSPHATE, PHOSPHATE ION
著者Buhrman, G.K, Rose, R.B, Enriquez, P, Truong, V.
登録日2020-10-05
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure, Function, and Thermal Adaptation of the Biotin Carboxylase Domain Dimer from Hydrogenobacter thermophilus 2-Oxoglutarate Carboxylase.
Biochemistry, 60, 2021
7KBL
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Biotin Carboxylase domain of Thermophilic 2-Oxoglutarate Carboxylase bound to Bicarbonate
分子名称: 2-oxoglutarate carboxylase small subunit, BICARBONATE ION
著者Buhrman, G.K, Rose, R.B, Enriquez, P, Truong, V.
登録日2020-10-02
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure, Function, and Thermal Adaptation of the Biotin Carboxylase Domain Dimer from Hydrogenobacter thermophilus 2-Oxoglutarate Carboxylase.
Biochemistry, 60, 2021
6YBQ
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Engineered glycolyl-CoA carboxylase (quintuple mutant) with bound CoA
分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, COENZYME A, Propionyl-CoA carboxylase alpha subunit, ...
著者Schuller, J.M, Schuller, S.K, Zarzycki, J, Scheffen, M, Marchal, D.M, Erb, T.J.
登録日2020-03-17
公開日2020-10-28
最終更新日2021-05-12
実験手法ELECTRON MICROSCOPY (1.96 Å)
主引用文献A new-to-nature carboxylation module to improve natural and synthetic CO2 fixation
Nat Catal, 2021
6YBP
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Propionyl-CoA carboxylase of Methylorubrum extorquens with bound CoA
分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, COENZYME A, Propionyl-CoA carboxylase alpha subunit, ...
著者Schuller, J.M, Schuller, S.K, Zarzycki, J, Scheffen, M, Marchal, D.M, Erb, T.J.
登録日2020-03-17
公開日2020-10-28
最終更新日2021-05-12
実験手法ELECTRON MICROSCOPY (3.48 Å)
主引用文献A new-to-nature carboxylation module to improve natural and synthetic CO2 fixation
Nat Catal, 2021
6W2J
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CPS1 bound to allosteric inhibitor H3B-374
分子名称: (2-fluoranyl-4-methoxy-phenyl)-[(3~{R},5~{R})-4-(2-fluoranyl-4-methoxy-phenyl)carbonyl-3,5-dimethyl-piperazin-1-yl]methanone, 1,2-ETHANEDIOL, Carbamoyl-phosphate synthase [ammonia], ...
著者Larsen, N.A, Nguyen, T.V.
登録日2020-03-05
公開日2021-01-13
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.62 Å)
主引用文献Discovery of 2,6-Dimethylpiperazines as Allosteric Inhibitors of CPS1.
Acs Med.Chem.Lett., 11, 2020
6UEL
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CPS1 bound to allosteric inhibitor H3B-193
分子名称: Carbamoyl-phosphate synthase [ammonia], mitochondrial, N~1~-[(4-fluorophenyl)methyl]-N~1~-methyl-N~4~-(4-methyl-1,3-thiazol-2-yl)piperidine-1,4-dicarboxamide, ...
著者Larsen, N.A, Nguyen, T.V.
登録日2019-09-21
公開日2020-03-18
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Small Molecule Inhibition of CPS1 Activity through an Allosteric Pocket.
Cell Chem Biol, 27, 2020
6OJH
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Crystal Structure of Haemophilus Influenzae Biotin Carboxylase Complexed with (R)-7-(3-aminopyrrolidin-1-yl)-6-(naphthalen-1-yl)pyrido[2,3-d]pyrimidin-2-amine
分子名称: 7-[(3R)-3-aminopyrrolidin-1-yl]-6-(naphthalen-1-yl)pyrido[2,3-d]pyrimidin-2-amine, ACETATE ION, Biotin carboxylase, ...
著者Andrews, L.D, Kane, T.R, Dozzo, P, Haglund, C.M, Hilderbrandt, D.J, Linsell, M.S, Machajewski, T, McEnroe, G, Serio, A.W, Wlasichuk, K.B, Neau, D.B, Pakhomova, S, Waldrop, G.L, Sharp, M, Pogliano, J, Cirz, R, Cohen, F.
登録日2019-04-11
公開日2020-02-12
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Crystal Structure of Haemophilus Influenzae Biotin Carboxylase Complexed with (R)-7-(3-aminopyrrolidin-1-yl)-6-(naphthalen-1-yl)pyrido[2,3-d]pyrimidin-2-amine
To Be Published
6OI8
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Crystal Structure of Haemophilus Influenzae Biotin Carboxylase Complexed with 7-((1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)-6-(2-chloro-6-(pyridin-3-yl)phenyl)pyrido[2,3-d]pyrimidin-2-amine
分子名称: 1,2-ETHANEDIOL, 7-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-6-[2-chloro-6-(pyridin-3-yl)phenyl]pyrido[2,3-d]pyrimidin-2-amine, Biotin carboxylase
著者Andrews, L.D, Kane, T.R, Dozzo, P, Haglund, C.M, Hilderbrandt, D.J, Linsell, M.S, Machajewski, T, McEnroe, G, Serio, A.W, Wlasichuk, K.B, Neau, D.B, Pakhomova, S, Waldrop, G.L, Sharp, M, Pogliano, J, Cirz, R, Cohen, F.
登録日2019-04-09
公開日2019-07-31
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Optimization and Mechanistic Characterization of Pyridopyrimidine Inhibitors of Bacterial Biotin Carboxylase.
J.Med.Chem., 62, 2019
6OI9
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Crystal Structure of E. coli Biotin Carboxylase Complexed with 7-[3-(aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-2-amine
分子名称: 1,2-ETHANEDIOL, 7-[(3S)-3-(aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-2-amine, Biotin carboxylase
著者Andrews, L.D, Kane, T.R, Dozzo, P, Haglund, C.M, Hilderbrandt, D.J, Linsell, M.S, Machajewski, T, McEnroe, G, Serio, A.W, Wlasichuk, K.B, Neau, D.B, Pakhomova, S, Waldrop, G.L, Sharp, M, Pogliano, J, Cirz, R, Cohen, F.
登録日2019-04-09
公開日2019-07-31
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Optimization and Mechanistic Characterization of Pyridopyrimidine Inhibitors of Bacterial Biotin Carboxylase.
J.Med.Chem., 62, 2019
6G2I
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BU of 6g2i by Molmil
Filament of acetyl-CoA carboxylase and BRCT domains of BRCA1 (ACC-BRCT) at 5.9 A resolution
分子名称: Acetyl-CoA carboxylase 1, Breast cancer type 1 susceptibility protein
著者Hunkeler, M, Hagmann, A, Stuttfeld, E, Chami, M, Stahlberg, H, Maier, T.
登録日2018-03-23
公開日2018-06-13
最終更新日2019-12-11
実験手法ELECTRON MICROSCOPY (5.9 Å)
主引用文献Structural basis for regulation of human acetyl-CoA carboxylase.
Nature, 558, 2018
6G2D
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Citrate-induced acetyl-CoA carboxylase (ACC-Cit) filament at 5.4 A resolution
分子名称: Acetyl-CoA carboxylase 1
著者Hunkeler, M, Hagmann, A, Stuttfeld, E, Chami, M, Stahlberg, H, Maier, T.
登録日2018-03-23
公開日2018-06-13
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (5.4 Å)
主引用文献Structural basis for regulation of human acetyl-CoA carboxylase.
Nature, 558, 2018
6G2H
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BU of 6g2h by Molmil
Filament of acetyl-CoA carboxylase and BRCT domains of BRCA1 (ACC-BRCT) core at 4.6 A resolution
分子名称: Acetyl-CoA carboxylase 1
著者Hunkeler, M, Hagmann, A, Stuttfeld, E, Chami, M, Stahlberg, H, Maier, T.
登録日2018-03-23
公開日2018-06-13
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (4.6 Å)
主引用文献Structural basis for regulation of human acetyl-CoA carboxylase.
Nature, 558, 2018
5MLK
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BU of 5mlk by Molmil
Biotin dependent carboxylase AccA3 dimer from Mycobacterium tuberculosis (Rv3285)
分子名称: Acetyl-COA carboxylase
著者Bennett, M.D, Hogbom, M.
登録日2016-12-07
公開日2017-03-08
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.939 Å)
主引用文献Crystal structure of the essential biotin-dependent carboxylase AccA3 from Mycobacterium tuberculosis.
FEBS Open Bio, 7, 2017
5KS8
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BU of 5ks8 by Molmil
Crystal structure of two-subunit pyruvate carboxylase from Methylobacillus flagellatus
分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, MANGANESE (II) ION, PYRUVIC ACID, ...
著者Choi, P.H, Tong, L.
登録日2016-07-07
公開日2016-10-19
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3.01 Å)
主引用文献A distinct holoenzyme organization for two-subunit pyruvate carboxylase.
Nat Commun, 7, 2016
5KKN
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Crystal structure of human ACC2 BC domain in complex with ND-646, the primary amide of ND-630
分子名称: 2-[1-[(2~{R})-2-(2-methoxyphenyl)-2-(oxan-4-yloxy)ethyl]-5-methyl-6-(1,3-oxazol-2-yl)-2,4-bis(oxidanylidene)thieno[2,3-d]pyrimidin-3-yl]-2-methyl-propanamide, Acetyl-CoA carboxylase 2
著者Wang, R, Paul, D, Tong, L.
登録日2016-06-22
公開日2016-07-13
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.
Proc.Natl.Acad.Sci.USA, 113, 2016
5I8I
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BU of 5i8i by Molmil
Crystal Structure of the K. lactis Urea Amidolyase
分子名称: Urea Amidolyase
著者Zhao, J, Xiang, S.
登録日2016-02-19
公開日2017-04-05
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (6.5 Å)
主引用文献Structure and function of urea amidolyase.
Biosci. Rep., 38, 2018
5I6I
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BU of 5i6i by Molmil
Crystal structure of a dBCCP-variant of Chaetomium thermophilum acetyl-CoA carboxylase
分子名称: Acetyl-CoA carboxylase-like protein,Acetyl-CoA carboxylase-like protein,Acetyl-CoA carboxylase-like protein
著者Hunkeler, M, Stuttfeld, E, Hagmann, A, Imseng, S, Maier, T.
登録日2016-02-16
公開日2016-04-20
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (8.4 Å)
主引用文献The dynamic organization of fungal acetyl-CoA carboxylase.
Nat Commun, 7, 2016
5H80
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Biotin Carboxylase domain of single-chain bacterial carboxylase
分子名称: 1,2-ETHANEDIOL, Carboxylase
著者Hagmann, A, Hunkeler, M, Stuttfeld, E, Maier, T.
登録日2015-12-23
公開日2016-07-20
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Hybrid Structure of a Dynamic Single-Chain Carboxylase from Deinococcus radiodurans.
Structure, 24, 2016
5DOU
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BU of 5dou by Molmil
Crystal Structure of Human Carbamoyl phosphate synthetase I (CPS1), ligand-bound form
分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ...
著者de Cima, S, Polo, L.M, Fita, I, Rubio, V.
登録日2015-09-11
公開日2015-12-09
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis.
Sci Rep, 5, 2015
5DOT
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BU of 5dot by Molmil
Crystal Structure of Human Carbamoyl phosphate synthetase I (CPS1), apo form
分子名称: 1,2-ETHANEDIOL, Carbamoyl-phosphate synthase [ammonia], mitochondrial, ...
著者Polo, L.M, de Cima, S, Fita, I, Rubio, V.
登録日2015-09-11
公開日2015-12-09
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis.
Sci Rep, 5, 2015
5CSL
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BU of 5csl by Molmil
Crystal structure of the 500 kD yeast acetyl-CoA carboxylase holoenzyme dimer
分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Acetyl-CoA carboxylase, COENZYME A
著者Wei, J, Tong, L.
登録日2015-07-23
公開日2015-10-28
最終更新日2022-03-23
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer.
Nature, 526, 2015

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