6OI9
Crystal Structure of E. coli Biotin Carboxylase Complexed with 7-[3-(aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-2-amine
Summary for 6OI9
Entry DOI | 10.2210/pdb6oi9/pdb |
Descriptor | Biotin carboxylase, 7-[(3S)-3-(aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-2-amine, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | atp grasp, carboxylase, biotin carboxyl carrier protein and carboxyltransferase, ligase |
Biological source | Escherichia coli UMNK88 |
Total number of polymer chains | 2 |
Total formula weight | 104080.80 |
Authors | Andrews, L.D.,Kane, T.R.,Dozzo, P.,Haglund, C.M.,Hilderbrandt, D.J.,Linsell, M.S.,Machajewski, T.,McEnroe, G.,Serio, A.W.,Wlasichuk, K.B.,Neau, D.B.,Pakhomova, S.,Waldrop, G.L.,Sharp, M.,Pogliano, J.,Cirz, R.,Cohen, F. (deposition date: 2019-04-09, release date: 2019-07-31, Last modification date: 2023-10-11) |
Primary citation | Andrews, L.D.,Kane, T.R.,Dozzo, P.,Haglund, C.M.,Hilderbrandt, D.J.,Linsell, M.S.,Machajewski, T.,McEnroe, G.,Serio, A.W.,Wlasichuk, K.B.,Neau, D.B.,Pakhomova, S.,Waldrop, G.L.,Sharp, M.,Pogliano, J.,Cirz, R.T.,Cohen, F. Optimization and Mechanistic Characterization of Pyridopyrimidine Inhibitors of Bacterial Biotin Carboxylase. J.Med.Chem., 62:7489-7505, 2019 Cited by PubMed: 31306011DOI: 10.1021/acs.jmedchem.9b00625 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.06 Å) |
Structure validation
Download full validation report