6OJH

Crystal Structure of Haemophilus Influenzae Biotin Carboxylase Complexed with (R)-7-(3-aminopyrrolidin-1-yl)-6-(naphthalen-1-yl)pyrido[2,3-d]pyrimidin-2-amine

Summary for 6OJH

• Entry DOI: 10.2210/pdb6ojh/pdb
• Descriptor: Biotin carboxylase, 7-[(3R)-3-aminopyrrolidin-1-yl]-6-(naphthalen-1-yl)pyrido[2,3-d]pyrimidin-2-amine, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: atp grasp, carboxylase, inhibitor, ligase
• Biological source: Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
• Total number of polymer chains: 1
• Total formula weight: 51802.10

Authors

Andrews, L.D.,Kane, T.R.,Dozzo, P.,Haglund, C.M.,Hilderbrandt, D.J.,Linsell, M.S.,Machajewski, T.,McEnroe, G.,Serio, A.W.,Wlasichuk, K.B.,Neau, D.B.,Pakhomova, S.,Waldrop, G.L.,Sharp, M.,Pogliano, J.,Cirz, R.,Cohen, F. (deposition date: 2019-04-11, release date: 2020-02-12, Last modification date: 2023-10-11)

• Primary citation: Andrews, L.D.,Kane, T.R.,Dozzo, P.,Haglund, C.M.,Hilderbrandt, D.J.,Linsell, M.S.,Machajewski, T.,McEnroe, G.,Serio, A.W.,Wlasichuk, K.B.,Neau, D.B.,Pakhomova, S.,Waldrop, G.L.,Sharp, M.,Pogliano, J.,Cirz, R.,Cohen, F.; Crystal Structure of Haemophilus Influenzae Biotin Carboxylase Complexed with (R)-7-(3-aminopyrrolidin-1-yl)-6-(naphthalen-1-yl)pyrido[2,3-d]pyrimidin-2-amine; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.05 Å)