6OI8
Crystal Structure of Haemophilus Influenzae Biotin Carboxylase Complexed with 7-((1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)-6-(2-chloro-6-(pyridin-3-yl)phenyl)pyrido[2,3-d]pyrimidin-2-amine
Summary for 6OI8
Entry DOI | 10.2210/pdb6oi8/pdb |
Related | 4MV1 4MV3 4MV4 4MV6 4MV7 4MV8 4MV9 4RZQ |
Descriptor | Biotin carboxylase, 1,2-ETHANEDIOL, 7-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-6-[2-chloro-6-(pyridin-3-yl)phenyl]pyrido[2,3-d]pyrimidin-2-amine, ... (4 entities in total) |
Functional Keywords | atp grasp, carboxylase, inhibitor, ligase |
Biological source | Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) |
Total number of polymer chains | 1 |
Total formula weight | 51838.53 |
Authors | Andrews, L.D.,Kane, T.R.,Dozzo, P.,Haglund, C.M.,Hilderbrandt, D.J.,Linsell, M.S.,Machajewski, T.,McEnroe, G.,Serio, A.W.,Wlasichuk, K.B.,Neau, D.B.,Pakhomova, S.,Waldrop, G.L.,Sharp, M.,Pogliano, J.,Cirz, R.,Cohen, F. (deposition date: 2019-04-09, release date: 2019-07-31, Last modification date: 2023-10-11) |
Primary citation | Andrews, L.D.,Kane, T.R.,Dozzo, P.,Haglund, C.M.,Hilderbrandt, D.J.,Linsell, M.S.,Machajewski, T.,McEnroe, G.,Serio, A.W.,Wlasichuk, K.B.,Neau, D.B.,Pakhomova, S.,Waldrop, G.L.,Sharp, M.,Pogliano, J.,Cirz, R.T.,Cohen, F. Optimization and Mechanistic Characterization of Pyridopyrimidine Inhibitors of Bacterial Biotin Carboxylase. J.Med.Chem., 62:7489-7505, 2019 Cited by PubMed: 31306011DOI: 10.1021/acs.jmedchem.9b00625 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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