PDB: 32 件ウェブページステータス検索Chemie searchBIRD

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6VWU	X-ray structure of ALKS 4230, a fusion of circularly permuted human Interleukin-2 and Interleukin-2 Receptor alpha 分子名称: Interleukin-2,Interleukin-2 receptor subunit alpha 著者 Losey, H.C. 登録日 2020-02-20 公開日 2020-04-29 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 ALKS 4230: a novel engineered IL-2 fusion protein with an improved cellular selectivity profile for cancer immunotherapy. J Immunother Cancer, 8, 2020
6YE3	IL-2 in complex with a Fab fragment from UFKA-20 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chains: A,D,G, Chains: B,E,H, ... 著者 Karakus, U, Mittl, P, Boyman, O. 登録日 2020-03-23 公開日 2020-12-30 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 Receptor-gated IL-2 delivery by an anti-human IL-2 antibody activates regulatory T cells in three different species. Sci Transl Med, 12, 2020
7DR4	Complex of anti-human IL-2 antibody and human IL-2 分子名称: Interleukin-2, anti-human IL-2 antibody, mouse Ig G, ... 著者 Kim, M.S, Kim, J.E. 登録日 2020-12-25 公開日 2021-04-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 Crystal structure of human interleukin-2 in complex with TCB2, a new antibody-drug candidate with antitumor activity. Oncoimmunology, 10, 2021
7M2G	INTERLEUKIN-2 (human) mutant P65K, C125S 分子名称: GLYCEROL, Interleukin-2, SULFATE ION 著者 Ptacin, J.L, Milla, M.E, Steinbacher, S, Maskos, K, Thomsen, M. 登録日 2021-03-16 公開日 2021-08-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism. Nat Commun, 12, 2021
7RA9	Designed StabIL-2 seq1 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Interleukin-2, PHOSPHATE ION 著者 Jude, K.M, Chu, A.E, Huang, P.-S, Garcia, K.C. 登録日 2021-06-30 公開日 2022-03-16 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Interleukin-2 superkines by computational design. Proc.Natl.Acad.Sci.USA, 119, 2022
7RAA	Designed StabIL-2 seq15 分子名称: Interleukin-2, MAGNESIUM ION 著者 Jude, K.M, Chu, A.E, Huang, P.-S, Garcia, K.C. 登録日 2021-06-30 公開日 2022-03-16 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Interleukin-2 superkines by computational design. Proc.Natl.Acad.Sci.USA, 119, 2022
7ZMZ	Engineered Interleukin 2 bound to CD25 receptor 分子名称: Interleukin-2, Interleukin-2 receptor subunit alpha 著者 Fyfe, P.K, Moraga, I, Gaggero, S, Mitra, S. 登録日 2022-04-20 公開日 2022-12-14 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein. Sci Immunol, 7, 2022

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