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6VWU
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BU of 6vwu by Molmil
X-ray structure of ALKS 4230, a fusion of circularly permuted human Interleukin-2 and Interleukin-2 Receptor alpha
分子名称: Interleukin-2,Interleukin-2 receptor subunit alpha
著者Losey, H.C.
登録日2020-02-20
公開日2020-04-29
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献ALKS 4230: a novel engineered IL-2 fusion protein with an improved cellular selectivity profile for cancer immunotherapy.
J Immunother Cancer, 8, 2020
6YE3
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BU of 6ye3 by Molmil
IL-2 in complex with a Fab fragment from UFKA-20
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chains: A,D,G, Chains: B,E,H, ...
著者Karakus, U, Mittl, P, Boyman, O.
登録日2020-03-23
公開日2020-12-30
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献Receptor-gated IL-2 delivery by an anti-human IL-2 antibody activates regulatory T cells in three different species.
Sci Transl Med, 12, 2020
7DR4
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BU of 7dr4 by Molmil
Complex of anti-human IL-2 antibody and human IL-2
分子名称: Interleukin-2, anti-human IL-2 antibody, mouse Ig G, ...
著者Kim, M.S, Kim, J.E.
登録日2020-12-25
公開日2021-04-14
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Crystal structure of human interleukin-2 in complex with TCB2, a new antibody-drug candidate with antitumor activity.
Oncoimmunology, 10, 2021
7M2G
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BU of 7m2g by Molmil
INTERLEUKIN-2 (human) mutant P65K, C125S
分子名称: GLYCEROL, Interleukin-2, SULFATE ION
著者Ptacin, J.L, Milla, M.E, Steinbacher, S, Maskos, K, Thomsen, M.
登録日2021-03-16
公開日2021-08-04
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism.
Nat Commun, 12, 2021
7RA9
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BU of 7ra9 by Molmil
Designed StabIL-2 seq1
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Interleukin-2, PHOSPHATE ION
著者Jude, K.M, Chu, A.E, Huang, P.-S, Garcia, K.C.
登録日2021-06-30
公開日2022-03-16
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Interleukin-2 superkines by computational design.
Proc.Natl.Acad.Sci.USA, 119, 2022
7RAA
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BU of 7raa by Molmil
Designed StabIL-2 seq15
分子名称: Interleukin-2, MAGNESIUM ION
著者Jude, K.M, Chu, A.E, Huang, P.-S, Garcia, K.C.
登録日2021-06-30
公開日2022-03-16
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.69 Å)
主引用文献Interleukin-2 superkines by computational design.
Proc.Natl.Acad.Sci.USA, 119, 2022
7ZMZ
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BU of 7zmz by Molmil
Engineered Interleukin 2 bound to CD25 receptor
分子名称: Interleukin-2, Interleukin-2 receptor subunit alpha
著者Fyfe, P.K, Moraga, I, Gaggero, S, Mitra, S.
登録日2022-04-20
公開日2022-12-14
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein.
Sci Immunol, 7, 2022
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件を2024-06-12に公開中

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