3EWB
 
 | | Crystal structure of N-terminal domain of putative 2-isopropylmalate synthase from Listeria monocytogenes | | 分子名称: | 2-isopropylmalate synthase | | 著者 | Ramagopal, U.A, Toro, R, Gilmore, M, Hu, S, Maletic, M, Rodgers, L, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | | 登録日 | 2008-10-14 | | 公開日 | 2008-12-23 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structure of N-terminal domain of putative 2-isopropylmalate synthase from Listeria monocytogenes.
To be Published
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3FIG
 | | Crystal Structure of Leucine-bound LeuA from Mycobacterium tuberculosis | | 分子名称: | 2-isopropylmalate synthase, GLYCEROL, LEUCINE, ... | | 著者 | Koon, N, Squire, C.J, Baker, E.N. | | 登録日 | 2008-12-11 | | 公開日 | 2008-12-23 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of LeuA from Mycobacterium tuberculosis, a key enzyme in leucine biosynthesis.
Proc.Natl.Acad.Sci.USA, 101, 2004
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3HB9
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3HBL
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3HO8
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3HPS
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3HPX
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3HPZ
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3HQ1
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3IVS
 | | Homocitrate Synthase Lys4 | | 分子名称: | COBALT (II) ION, Homocitrate synthase, mitochondrial, ... | | 著者 | Bulfer, S.L, Scott, E.M, Couture, J.-F, Pillus, L, Trievel, R.C. | | 登録日 | 2009-09-01 | | 公開日 | 2009-09-22 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | | 主引用文献 | Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.
J.Biol.Chem., 284, 2009
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3IVT
 | | Homocitrate Synthase Lys4 bound to 2-OG | | 分子名称: | 2-OXOGLUTARIC ACID, Homocitrate synthase, mitochondrial, ... | | 著者 | Bulfer, S.L, Scott, E.M, Couture, J.-F, Pillus, L, Trievel, R.C. | | 登録日 | 2009-09-01 | | 公開日 | 2009-09-22 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | | 主引用文献 | Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.
J.Biol.Chem., 284, 2009
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3IVU
 | | Homocitrate Synthase Lys4 bound to 2-OG | | 分子名称: | 2-OXOGLUTARIC ACID, COBALT (II) ION, Homocitrate synthase, ... | | 著者 | Bulfer, S.L, Scott, E.M, Couture, J.-F, Pillus, L, Trievel, R.C. | | 登録日 | 2009-09-01 | | 公開日 | 2009-09-22 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.72 Å) | | 主引用文献 | Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis.
J.Biol.Chem., 284, 2009
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3MI3
 | | Homocitrate Synthase Lys4 bound to Lysine | | 分子名称: | Homocitrate synthase, mitochondrial, LYSINE, ... | | 著者 | Bulfer, S.L, Scott, E.M, Pillus, L, Trievel, R.C. | | 登録日 | 2010-04-09 | | 公開日 | 2010-04-28 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | | 主引用文献 | Structural Basis for L-lysine Feedback Inhibition of Homocitrate Synthase
J.Biol.Chem., 285, 2010
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3MP3
 | | Crystal Structure of Human Lyase in complex with inhibitor HG-CoA | | 分子名称: | (3R,5S,9R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8-dimethyl-10,14,19-trioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide, 3-HYDROXYPENTANEDIOIC ACID, Hydroxymethylglutaryl-CoA lyase, ... | | 著者 | Fu, Z, Runquist, J.A, Montgomery, C, Miziorko, H.M, Kim, J.-J.P. | | 登録日 | 2010-04-24 | | 公開日 | 2010-06-16 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes.
J.Biol.Chem., 285, 2010
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3MP4
 | | Crystal structure of Human lyase R41M mutant | | 分子名称: | Hydroxymethylglutaryl-CoA lyase | | 著者 | Fu, Z, Runquist, J.A, Montgomery, C, Miziorko, H.M, Kim, J.-J.P. | | 登録日 | 2010-04-24 | | 公開日 | 2010-06-16 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes.
J.Biol.Chem., 285, 2010
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3MP5
 | | Crystal Structure of Human Lyase R41M in complex with HMG-CoA | | 分子名称: | 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, Hydroxymethylglutaryl-CoA lyase, MAGNESIUM ION | | 著者 | Fu, Z, Runquist, J.A, Montgomery, C, Miziorko, H.M, Kim, J.-J.P. | | 登録日 | 2010-04-24 | | 公開日 | 2010-06-16 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Functional insights into human HMG-CoA lyase from structures of Acyl-CoA-containing ternary complexes.
J.Biol.Chem., 285, 2010
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3RMJ
 | | Crystal structure of truncated alpha-Isopropylmalate Synthase from Neisseria meningitidis | | 分子名称: | 2-isopropylmalate synthase, GLYCEROL, MAGNESIUM ION, ... | | 著者 | Huisman, F.H.A, Baker, H.M, Koon, N, Baker, E.N, Parker, E.J. | | 登録日 | 2011-04-20 | | 公開日 | 2012-03-14 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Removal of the C-terminal regulatory domain of alpha-isopropylmalate synthase disrupts functional substrate binding
Biochemistry, 51, 2012
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3TW6
 | | Structure of Rhizobium etli pyruvate carboxylase T882A with the allosteric activator, acetyl coenzyme-A | | 分子名称: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... | | 著者 | St Maurice, M, Kumar, S, Lietzan, A.D. | | 登録日 | 2011-09-21 | | 公開日 | 2011-10-19 | | 最終更新日 | 2011-12-28 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Interaction between the biotin carboxyl carrier domain and the biotin carboxylase domain in pyruvate carboxylase from Rhizobium etli.
Biochemistry, 50, 2011
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3TW7
 | | Structure of Rhizobium etli pyruvate carboxylase T882A crystallized without acetyl coenzyme-A | | 分子名称: | CHLORIDE ION, MAGNESIUM ION, Pyruvate carboxylase protein, ... | | 著者 | St Maurice, M, Kumar, S, Lietzan, A.D. | | 登録日 | 2011-09-21 | | 公開日 | 2011-10-12 | | 最終更新日 | 2011-12-28 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Interaction between the biotin carboxyl carrier domain and the biotin carboxylase domain in pyruvate carboxylase from Rhizobium etli.
Biochemistry, 50, 2011
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3U6W
 | | Truncated M. tuberculosis LeuA (1-425) complexed with KIV | | 分子名称: | 2-isopropylmalate synthase, 3-METHYL-2-OXOBUTANOIC ACID, GLYCEROL, ... | | 著者 | Koon, N, Baker, E.N, Squire, C.J. | | 登録日 | 2011-10-13 | | 公開日 | 2012-03-14 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | Removal of the C-terminal regulatory domain of alpha-isopropylmalate synthase disrupts functional substrate binding.
Biochemistry, 51, 2012
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4HNT
 | | crystal structure of F403A mutant of S. aureus Pyruvate carboxylase | | 分子名称: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Yu, L.P.C, Tong, L. | | 登録日 | 2012-10-21 | | 公開日 | 2013-01-16 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Characterizing the Importance of the Biotin Carboxylase Domain Dimer for Staphylococcus aureus Pyruvate Carboxylase Catalysis.
Biochemistry, 52, 2013
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4HNU
 | | crystal structure of K442E mutant of S. aureus Pyruvate carboxylase | | 分子名称: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... | | 著者 | Yu, L.P.C, Tong, L. | | 登録日 | 2012-10-21 | | 公開日 | 2013-01-16 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Characterizing the Importance of the Biotin Carboxylase Domain Dimer for Staphylococcus aureus Pyruvate Carboxylase Catalysis.
Biochemistry, 52, 2013
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4HNV
 | | Crystal structure of R54E mutant of S. aureus Pyruvate carboxylase | | 分子名称: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Yu, L.P.C, Tong, L. | | 登録日 | 2012-10-21 | | 公開日 | 2013-01-16 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Characterizing the Importance of the Biotin Carboxylase Domain Dimer for Staphylococcus aureus Pyruvate Carboxylase Catalysis.
Biochemistry, 52, 2013
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4JN6
 | | Crystal Structure of the Aldolase-Dehydrogenase Complex from Mycobacterium tuberculosis HRv37 | | 分子名称: | 4-hydroxy-2-oxovalerate aldolase, Acetaldehyde dehydrogenase, MANGANESE (II) ION, ... | | 著者 | Carere, J, McKenna, S.E, Kimber, M.S, Seah, S.Y.K. | | 登録日 | 2013-03-14 | | 公開日 | 2013-05-08 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Characterization of an Aldolase-Dehydrogenase Complex from the Cholesterol Degradation Pathway of Mycobacterium tuberculosis.
Biochemistry, 52, 2013
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4JX4
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