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6ADA
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BU of 6ada by Molmil
Crystal structure of the E148D mutant CLC-ec1 in 200mM bromide
分子名称: BROMIDE ION, H(+)/Cl(-) exchange transporter ClcA, antibody Fab fragment, ...
著者Lim, H.-H, Park, K.
登録日2018-07-31
公開日2019-08-28
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.153 Å)
主引用文献Mutation of external glutamate residue reveals a new intermediate transport state and anion binding site in a CLC Cl-/H+antiporter.
Proc.Natl.Acad.Sci.USA, 116, 2019
7CVT
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BU of 7cvt by Molmil
Crystal structure of the C85A/L194A/H234C mutant CLC-ec1 with Fab fragment
分子名称: CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA, antibody Fab fragment heavy chain, ...
著者Park, K, Mersch, K, Robertson, J, Lim, H.-H.
登録日2020-08-27
公開日2021-09-01
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Altering CLC stoichiometry by reducing non-polar side-chains at the dimerization interface.
J.Mol.Biol., 433, 2021
8TA4
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BU of 8ta4 by Molmil
Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with symmetric C-terminal
分子名称: CHLORIDE ION, Chloride channel protein 2
著者Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M.
登録日2023-06-26
公開日2024-01-31
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (2.75 Å)
主引用文献CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism.
Elife, 12, 2024
8TA5
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BU of 8ta5 by Molmil
Title: Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with asymmetric C-terminal
分子名称: Chloride channel protein 2
著者Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M.
登録日2023-06-26
公開日2024-01-31
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (2.76 Å)
主引用文献CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism.
Elife, 12, 2024
8TA2
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BU of 8ta2 by Molmil
Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with bound inhibitor AK-42
分子名称: 2-[[2,6-bis(chloranyl)-3-phenylmethoxy-phenyl]amino]pyridine-3-carboxylic acid, CHLORIDE ION, Chloride channel protein 2
著者Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M.
登録日2023-06-26
公開日2024-01-31
最終更新日2024-02-28
実験手法ELECTRON MICROSCOPY (2.74 Å)
主引用文献CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism.
Elife, 12, 2024
8TA6
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BU of 8ta6 by Molmil
Cryo-EM structure of the human CLC-2 chloride channel C-terminal domain
分子名称: Chloride channel protein 2
著者Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M.
登録日2023-06-26
公開日2024-01-31
最終更新日2024-02-28
実験手法ELECTRON MICROSCOPY (4.03 Å)
主引用文献CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism.
Elife, 12, 2024
8TA3
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BU of 8ta3 by Molmil
Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain Apo state with resolved N-terminal hairpin
分子名称: CHLORIDE ION, Chloride channel protein 2
著者Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M.
登録日2023-06-26
公開日2024-01-31
最終更新日2024-02-28
実験手法ELECTRON MICROSCOPY (2.46 Å)
主引用文献CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism.
Elife, 12, 2024
7CVS
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BU of 7cvs by Molmil
Crystal structure of the C85A/L194A mutant CLC-ec1 with Fab fragment
分子名称: CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA, antibody Fab fragment heavy chain, ...
著者Park, K, Mersch, K, Robertson, J, Lim, H.-H.
登録日2020-08-27
公開日2021-09-01
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.01 Å)
主引用文献Altering CLC stoichiometry by reducing non-polar side-chains at the dimerization interface.
J.Mol.Biol., 433, 2021
6COY
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BU of 6coy by Molmil
Human CLC-1 chloride ion channel, transmembrane domain
分子名称: CHLORIDE ION, Chloride channel protein 1
著者Park, E, MacKinnon, R.
登録日2018-03-13
公開日2018-06-13
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.36 Å)
主引用文献Structure of the CLC-1 chloride channel fromHomo sapiens.
Elife, 7, 2018
6COZ
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BU of 6coz by Molmil
Human CLC-1 chloride ion channel, C-terminal cytosolic domain
分子名称: Chloride channel protein 1
著者Park, E, MacKinnon, R.
登録日2018-03-13
公開日2018-06-13
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.36 Å)
主引用文献Structure of the CLC-1 chloride channel fromHomo sapiens.
Elife, 7, 2018
6QVD
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BU of 6qvd by Molmil
CryoEM structure of the human ClC-1 chloride channel, CBS state 2
分子名称: Chloride channel protein 1
著者Wang, K.T, Gourdon, P.E, Zhou, Z.H.
登録日2019-03-01
公開日2019-05-08
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (4.34 Å)
主引用文献Structure of the human ClC-1 chloride channel.
Plos Biol., 17, 2019
6QV6
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BU of 6qv6 by Molmil
CryoEM structure of the human ClC-1 chloride channel, membrane domain
分子名称: Chloride channel protein 1
著者Wang, K.T, Gourdon, P.E, Zhou, Z.H.
登録日2019-03-01
公開日2019-05-08
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.63 Å)
主引用文献Structure of the human ClC-1 chloride channel.
Plos Biol., 17, 2019
6QVB
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BU of 6qvb by Molmil
CryoEM structure of the human ClC-1 chloride channel, CBS state 3
分子名称: Chloride channel protein 1
著者Wang, K.T, Gourdon, P.E, Zhou, Z.H.
登録日2019-03-01
公開日2019-05-08
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (4.34 Å)
主引用文献Structure of the human ClC-1 chloride channel.
Plos Biol., 17, 2019
6QVU
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BU of 6qvu by Molmil
CryoEM structure of the human ClC-1 chloride channel, low pH
分子名称: Chloride channel protein 1
著者Wang, K.T, Gourdon, P.E, Zhou, Z.H.
登録日2019-03-05
公開日2019-05-08
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Structure of the human ClC-1 chloride channel.
Plos Biol., 17, 2019
6QVC
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BU of 6qvc by Molmil
CryoEM structure of the human ClC-1 chloride channel, CBS state 1
分子名称: Chloride channel protein 1
著者Wang, K.T, Gourdon, P.E, Zhou, Z.H.
登録日2019-03-01
公開日2019-05-08
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (4 Å)
主引用文献Structure of the human ClC-1 chloride channel.
Plos Biol., 17, 2019
8GQU
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BU of 8gqu by Molmil
AK-42 inhibitor binding human ClC-2 TMD
分子名称: 2-[[2,6-bis(chloranyl)-3-phenylmethoxy-phenyl]amino]pyridine-3-carboxylic acid, Chloride channel protein 2
著者Wang, L.
登録日2022-08-30
公開日2023-07-05
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42.
Nat Commun, 14, 2023
8GA1
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BU of 8ga1 by Molmil
CLC-ec1 R230C/L249C/C85A at pH 4.5 100mM Cl Swap
分子名称: CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA
著者Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A.
登録日2023-02-22
公開日2024-02-07
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献Structural basis of pH-dependent activation in a CLC transporter.
Nat.Struct.Mol.Biol., 31, 2024
8GAH
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BU of 8gah by Molmil
CLC-ec1 L25C/A450C/C85A at pH 4.5 100mM Cl Twist
分子名称: CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA
著者Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A.
登録日2023-02-22
公開日2024-02-07
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural basis of pH-dependent activation in a CLC transporter.
Nat.Struct.Mol.Biol., 31, 2024
8GA0
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BU of 8ga0 by Molmil
CLC-ec1 E202Y at pH 4.5 100mM Cl Turn
分子名称: H(+)/Cl(-) exchange transporter ClcA
著者Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A.
登録日2023-02-22
公開日2024-02-07
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural basis of pH-dependent activation in a CLC transporter.
Nat.Struct.Mol.Biol., 31, 2024
8GA3
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BU of 8ga3 by Molmil
CLC-ec1 R230C/L249C/C85A at pH 4.5 100mM Cl Turn
分子名称: CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA
著者Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A.
登録日2023-02-22
公開日2024-02-07
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural basis of pH-dependent activation in a CLC transporter.
Nat.Struct.Mol.Biol., 31, 2024
8GA5
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BU of 8ga5 by Molmil
CLC-ec1 L25C/A450C/C85A at pH 4.5 100mM Cl Intermediate
分子名称: CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA
著者Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A.
登録日2023-02-22
公開日2024-02-07
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献Structural basis of pH-dependent activation in a CLC transporter.
Nat.Struct.Mol.Biol., 31, 2024
7RP6
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BU of 7rp6 by Molmil
CLC-ec1 at pH 4.5 100 mM NaGluconate Swap
分子名称: H(+)/Cl(-) exchange transporter ClcA
著者Fortea, E, Boudker, O, Accardi, A.
登録日2021-08-03
公開日2022-11-16
実験手法ELECTRON MICROSCOPY (3.78 Å)
主引用文献Structural basis of common gate activation in CLC transporters
To Be Published
7RQ7
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BU of 7rq7 by Molmil
CLC-ec1 at pH 4.5 100mM Cl TWIST2
分子名称: H(+)/Cl(-) exchange transporter ClcA
著者Fortea, E, Boudker, O, Accardi, A.
登録日2021-08-05
公開日2022-11-16
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.95 Å)
主引用文献Structural basis of common gate activation in CLC transporters
To Be Published
7RSB
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BU of 7rsb by Molmil
CLC-ec1 at pH 4.5 100 mM NaGluconate Turn
分子名称: H(+)/Cl(-) exchange transporter ClcA
著者Fortea, E, Boudker, O, Accardi, A.
登録日2021-08-11
公開日2022-11-16
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.68 Å)
主引用文献Structural basis of common gate activation in CLC transporters
To Be Published
7RNX
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BU of 7rnx by Molmil
CLC-ec1 at pH 7.5 100mM Cl Swap
分子名称: H(+)/Cl(-) exchange transporter ClcA
著者Fortea, E, Boudker, O, Accardi, A.
登録日2021-07-30
公開日2022-11-16
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.42 Å)
主引用文献Structural basis of common gate activation in CLC transporters
To Be Published

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件を2024-06-12に公開中

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