8TA5
| Title: Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with asymmetric C-terminal | 分子名称: | Chloride channel protein 2 | 著者 | Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M. | 登録日 | 2023-06-26 | 公開日 | 2024-01-31 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | 主引用文献 | CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism. Elife, 12, 2024
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8TA4
| Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with symmetric C-terminal | 分子名称: | CHLORIDE ION, Chloride channel protein 2 | 著者 | Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M. | 登録日 | 2023-06-26 | 公開日 | 2024-01-31 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.75 Å) | 主引用文献 | CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism. Elife, 12, 2024
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8TA2
| Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with bound inhibitor AK-42 | 分子名称: | 2-[[2,6-bis(chloranyl)-3-phenylmethoxy-phenyl]amino]pyridine-3-carboxylic acid, CHLORIDE ION, Chloride channel protein 2 | 著者 | Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M. | 登録日 | 2023-06-26 | 公開日 | 2024-01-31 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (2.74 Å) | 主引用文献 | CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism. Elife, 12, 2024
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8TA6
| Cryo-EM structure of the human CLC-2 chloride channel C-terminal domain | 分子名称: | Chloride channel protein 2 | 著者 | Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M. | 登録日 | 2023-06-26 | 公開日 | 2024-01-31 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (4.03 Å) | 主引用文献 | CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism. Elife, 12, 2024
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6ADB
| Crystal structure of the E148N mutant CLC-ec1 in 20mM bromide | 分子名称: | BROMIDE ION, H(+)/Cl(-) exchange transporter ClcA, antibody Fab fragment, ... | 著者 | Lim, H.-H, Park, K. | 登録日 | 2018-07-31 | 公開日 | 2019-08-28 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.692 Å) | 主引用文献 | Mutation of external glutamate residue reveals a new intermediate transport state and anion binding site in a CLC Cl-/H+antiporter. Proc.Natl.Acad.Sci.USA, 116, 2019
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6AD7
| Crystal structure of the E148D mutant CLC-ec1 in 20 mM bromide | 分子名称: | BROMIDE ION, H(+)/Cl(-) exchange transporter ClcA, antibody Fab fragment heavy chain, ... | 著者 | Lim, H.-H, Park, K. | 登録日 | 2018-07-31 | 公開日 | 2019-08-28 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Mutation of external glutamate residue reveals a new intermediate transport state and anion binding site in a CLC Cl-/H+antiporter. Proc.Natl.Acad.Sci.USA, 116, 2019
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6ADC
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6ADA
| Crystal structure of the E148D mutant CLC-ec1 in 200mM bromide | 分子名称: | BROMIDE ION, H(+)/Cl(-) exchange transporter ClcA, antibody Fab fragment, ... | 著者 | Lim, H.-H, Park, K. | 登録日 | 2018-07-31 | 公開日 | 2019-08-28 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.153 Å) | 主引用文献 | Mutation of external glutamate residue reveals a new intermediate transport state and anion binding site in a CLC Cl-/H+antiporter. Proc.Natl.Acad.Sci.USA, 116, 2019
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6QVD
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6QVC
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6QV6
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6QVB
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6QVU
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6AD8
| Crystal structure of the E148D mutant CLC-ec1 in 50 mM bromide | 分子名称: | BROMIDE ION, H(+)/Cl(-) exchange transporter ClcA, antibody Fab fragment heavy chain, ... | 著者 | Lim, H.-H, Park, K. | 登録日 | 2018-07-31 | 公開日 | 2019-08-28 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Mutation of external glutamate residue reveals a new intermediate transport state and anion binding site in a CLC Cl-/H+antiporter. Proc.Natl.Acad.Sci.USA, 116, 2019
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8GQU
| AK-42 inhibitor binding human ClC-2 TMD | 分子名称: | 2-[[2,6-bis(chloranyl)-3-phenylmethoxy-phenyl]amino]pyridine-3-carboxylic acid, Chloride channel protein 2 | 著者 | Wang, L. | 登録日 | 2022-08-30 | 公開日 | 2023-07-05 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42. Nat Commun, 14, 2023
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8GA0
| CLC-ec1 E202Y at pH 4.5 100mM Cl Turn | 分子名称: | H(+)/Cl(-) exchange transporter ClcA | 著者 | Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A. | 登録日 | 2023-02-22 | 公開日 | 2024-02-07 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural basis of pH-dependent activation in a CLC transporter. Nat.Struct.Mol.Biol., 31, 2024
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8GAH
| CLC-ec1 L25C/A450C/C85A at pH 4.5 100mM Cl Twist | 分子名称: | CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA | 著者 | Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A. | 登録日 | 2023-02-22 | 公開日 | 2024-02-07 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis of pH-dependent activation in a CLC transporter. Nat.Struct.Mol.Biol., 31, 2024
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8GA3
| CLC-ec1 R230C/L249C/C85A at pH 4.5 100mM Cl Turn | 分子名称: | CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA | 著者 | Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A. | 登録日 | 2023-02-22 | 公開日 | 2024-02-07 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural basis of pH-dependent activation in a CLC transporter. Nat.Struct.Mol.Biol., 31, 2024
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8GA1
| CLC-ec1 R230C/L249C/C85A at pH 4.5 100mM Cl Swap | 分子名称: | CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA | 著者 | Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A. | 登録日 | 2023-02-22 | 公開日 | 2024-02-07 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structural basis of pH-dependent activation in a CLC transporter. Nat.Struct.Mol.Biol., 31, 2024
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8GA5
| CLC-ec1 L25C/A450C/C85A at pH 4.5 100mM Cl Intermediate | 分子名称: | CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA | 著者 | Fortea, E, Lee, S, Argyos, Y, Chadda, R, Ciftci, D, Huysmans, G, Robertson, J.L, Boudker, O, Accardi, A. | 登録日 | 2023-02-22 | 公開日 | 2024-02-07 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structural basis of pH-dependent activation in a CLC transporter. Nat.Struct.Mol.Biol., 31, 2024
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7CVT
| Crystal structure of the C85A/L194A/H234C mutant CLC-ec1 with Fab fragment | 分子名称: | CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA, antibody Fab fragment heavy chain, ... | 著者 | Park, K, Mersch, K, Robertson, J, Lim, H.-H. | 登録日 | 2020-08-27 | 公開日 | 2021-09-01 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Altering CLC stoichiometry by reducing non-polar side-chains at the dimerization interface. J.Mol.Biol., 433, 2021
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7CVS
| Crystal structure of the C85A/L194A mutant CLC-ec1 with Fab fragment | 分子名称: | CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA, antibody Fab fragment heavy chain, ... | 著者 | Park, K, Mersch, K, Robertson, J, Lim, H.-H. | 登録日 | 2020-08-27 | 公開日 | 2021-09-01 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | 主引用文献 | Altering CLC stoichiometry by reducing non-polar side-chains at the dimerization interface. J.Mol.Biol., 433, 2021
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7RNX
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7RP6
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7RO0
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