PDB: 85 件ウェブページステータス検索Chemie searchBIRD

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6CFI	Crystal structure of Rad4-Rad23 bound to a 6-4 photoproduct UV lesion 分子名称: DNA (5'-D(*AP*TP*TP*GP*TP*AP*GP*CP*(T64)P*TP*GP*GP*AP*TP*GP*TP*TP*GP*AP*GP*TP*CP*A)-3'), DNA repair protein RAD4, DNA('-D(*TP*TP*GP*AP*CP*TP*CP*AP*AP*CP*AP*TP*CP*CP*AP*AP*AP*GP*CP*TP*AP*CP*AP*A)-'), ... 著者 Min, J, Jeffrey, P.D. 登録日 2018-02-15 公開日 2019-02-27 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.36241913 Å) 主引用文献 Structure and mechanism of pyrimidine-pyrimidone (6-4) photoproduct recognition by the Rad4/XPC nucleotide excision repair complex. Nucleic Acids Res., 47, 2019
6IF1	Crystal structure of Ube2K and K48-linked di-ubiquitin complex 分子名称: Ubiquitin, Ubiquitin-conjugating enzyme E2 K 著者 Lee, J.-G, Youn, H.-S, Lee, Y, An, J.Y, Park, K.R, Kang, J.Y, Lim, J.J, Eom, S.H. 登録日 2018-09-18 公開日 2018-11-21 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.466 Å) 主引用文献 Crystal structure of the Ube2K/E2-25K and K48-linked di-ubiquitin complex provides structural insight into the mechanism of K48-specific ubiquitin chain synthesis. Biochem. Biophys. Res. Commun., 506, 2018
6C9D	Crystal structure of KA1-autoinhibited MARK1 kinase 分子名称: Serine/threonine-protein kinase MARK1,Serine/threonine-protein kinase MARK1 著者 Emptage, R.P, Marmorstein, R. 登録日 2018-01-26 公開日 2018-07-11 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.499 Å) 主引用文献 Structural Basis for MARK1 Kinase Autoinhibition by Its KA1 Domain. Structure, 26, 2018
5XBO	Lanthanoid tagging via an unnatural amino acid for protein structure characterization 分子名称: Polyubiquitin-B, TERBIUM(III) ION, UV excision repair protein RAD23 homolog A 著者 Jiang, W, Gu, X, Dong, X, Tang, C. 登録日 2017-03-21 公開日 2017-05-31 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Lanthanoid tagging via an unnatural amino acid for protein structure characterization J. Biomol. NMR, 67, 2017
5KZ8	Mark2 complex with 7-[(1S)-1-(4-fluorophenyl)ethyl]-5,5-dimethyl-2-(3-pyridylamino)pyrrolo[2,3-d]pyrimidin-6-one 分子名称: 5,5-dimethyl-7-[(1~{S})-4-oxidanyl-1~{H}-inden-1-yl]-2-phenylazanyl-pyrrolo[2,3-d]pyrimidin-6-one, Serine/threonine-protein kinase MARK2 著者 Su, H.P, Munshi, S.K. 登録日 2016-07-23 公開日 2017-05-31 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (3.21 Å) 主引用文献 Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors. Bioorg. Med. Chem. Lett., 27, 2017
5KZ7	Mark2 complex with 7-[(1S)-1-(4-fluorophenyl)ethyl]-5,5-dimethyl-2-(3-pyridylamino)pyrrolo[2,3-d]pyrimidin-6-one 分子名称: 7-[(1~{S})-1-(4-fluorophenyl)ethyl]-5,5-dimethyl-2-(pyridin-3-ylamino)pyrrolo[2,3-d]pyrimidin-6-one, Serine/threonine-protein kinase MARK2 著者 Su, H.P, Munshi, S.K. 登録日 2016-07-23 公開日 2017-05-31 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors. Bioorg. Med. Chem. Lett., 27, 2017
5EAK	Optimization of Microtubule Affinity Regulating Kinase (MARK) Inhibitors with Improved Physical Properties 分子名称: N-[(1S,2R)-2-aminocyclohexyl]-4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl]thiophene-2-carboxamide, Serine/threonine-protein kinase MARK2 著者 Su, H.P. 登録日 2015-10-16 公開日 2016-02-17 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties. Bioorg.Med.Chem.Lett., 26, 2016
5DFL	Crystal structure of Ube2K~Ubiquitin conjugate 分子名称: GLYCEROL, Ubiquitin, Ubiquitin-conjugating enzyme E2 K 著者 Middleton, A.J, Day, C.L. 登録日 2015-08-27 公開日 2015-12-02 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The molecular basis of lysine 48 ubiquitin chain synthesis by Ube2K. Sci Rep, 5, 2015
5ES1	CRYSTAL STRUCTURE OF MICROTUBULE AFFINITY-REGULATING KINASE 4 CATALYTIC DOMAIN IN COMPLEX WITH A PYRAZOLOPYRIMIDINE INHIBITOR 分子名称: MAP/microtubule affinity-regulating kinase 4, ~{N}-[(1~{R},6~{R})-6-azanyl-2,2-bis(fluoranyl)cyclohexyl]-5-ethyl-4-[6-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]thiophene-2-carboxamide 著者 Sack, J.S. 登録日 2015-11-16 公開日 2015-12-02 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure of microtubule affinity-regulating kinase 4 catalytic domain in complex with a pyrazolopyrimidine inhibitor. Acta Crystallogr F Struct Biol Commun, 72, 2016
4YIR	Crystal structure of Rad4-Rad23 crosslinked to an undamaged DNA 分子名称: DNA (5'-D(*AP*TP*TP*GP*TP*AP*GP*CP*G*GP*GP*GP*AP*TP*GP*TP*CP*GP*AP*GP*TP*CP*A)-3'), DNA (5'-D(*TP*TP*GP*AP*CP*TP*CP*(G47)P*AP*CP*AP*TP*CP*CP*CP*CP*CP*GP*CP*TP*AP*CP*AP*A)-3'), DNA repair protein RAD4, ... 著者 Min, J.-H, Chen, X, Kim, Y. 登録日 2015-03-02 公開日 2015-03-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.0501 Å) 主引用文献 Kinetic gating mechanism of DNA damage recognition by Rad4/XPC. Nat Commun, 6, 2015
2MRO	Structure of the complex of ubiquitin and the UBA domain from DNA-damage-inducible 1 protein (Ddi1) 分子名称: DNA damage-inducible protein 1, Polyubiquitin-B 著者 Zhang, D, Fushman, D. 登録日 2014-07-14 公開日 2015-02-04 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 DNA-Damage-Inducible 1 Protein (Ddi1) Contains an Uncharacteristic Ubiquitin-like Domain that Binds Ubiquitin. Structure, 23, 2015
2MR9	NMR structure of UBA domain of DNA-damage-inducible 1 protein (Ddi1) 分子名称: DNA damage-inducible protein 1 著者 Zhang, D, Fushman, D. 登録日 2014-07-02 公開日 2015-02-04 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 DNA-Damage-Inducible 1 Protein (Ddi1) Contains an Uncharacteristic Ubiquitin-like Domain that Binds Ubiquitin. Structure, 23, 2015
2LBC	solution structure of tandem UBA of USP13 分子名称: Ubiquitin carboxyl-terminal hydrolase 13 著者 Zhang, Y, Zhou, C, Zhou, Z, Song, A, Hu, H. 登録日 2011-03-29 公開日 2012-03-07 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Domain Analysis Reveals That a Deubiquitinating Enzyme USP13 Performs Non-Activating Catalysis for Lys63-Linked Polyubiquitin. Plos One, 6, 2011
3K9P	The crystal structure of E2-25K and ubiquitin complex 分子名称: Ubiquitin, Ubiquitin-conjugating enzyme E2 K 著者 Kang, G.B, Ko, S, Song, S.M, Lee, W, Eom, S.H. 登録日 2009-10-16 公開日 2010-09-08 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural basis of E2-25K/UBB+1 interaction leading to proteasome inhibition and neurotoxicity J.Biol.Chem., 285, 2010
3K9O	The crystal structure of E2-25K and UBB+1 complex 分子名称: Ubiquitin, Ubiquitin-conjugating enzyme E2 K 著者 Kang, G.B, Ko, S, Song, S.M, Lee, W, Eom, S.H. 登録日 2009-10-16 公開日 2010-09-08 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural Basis of E2-25K/UBB+1 Interaction for Neurotoxicity of Alzheimer Disease by Proteasome Inhibition To be Published
2KNZ	NMR structure of CIP75 UBA domain 分子名称: Ubiquilin-4 著者 Kieken, F, Spagnol, G, Su, V, Lau, A.F, Sorgen, P.L. 登録日 2009-09-08 公開日 2010-03-16 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 NMR structure note: UBA domain of CIP75. J.Biomol.Nmr, 46, 2010
3IHP	Covalent Ubiquitin-Usp5 Complex 分子名称: CHLORIDE ION, ETHANAMINE, Ubiquitin, ... 著者 Walker, J.R, Avvakumov, G.V, Xue, S, Butler-Cole, C, Weigelt, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) 登録日 2009-07-30 公開日 2009-12-29 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Covalent Ubiquitin-Usp5 Complex To be Published
2WZJ	Catalytic and UBA domain of kinase MARK2/(Par-1) K82R, T208E double mutant 分子名称: SERINE/THREONINE-PROTEIN KINASE MARK2 著者 Panneerselvam, S, Marx, A, Mandelkow, E.-M, Mandelkow, E. 登録日 2009-11-30 公開日 2009-12-22 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.786 Å) 主引用文献 Structure and Function of Polarity-Inducing Kinase Family Mark/Par-1 within the Branch of Ampk/Snf1-Related Kinases. Faseb J., 24, 2010
3IEC	Helicobacter pylori CagA Inhibits PAR1/MARK Family Kinases by Mimicking Host Substrates 分子名称: Cytotoxicity-associated immunodominant antigen, Serine/threonine-protein kinase MARK2 著者 Stebbins, C.E, Nesic, D, Miller, M. 登録日 2009-07-22 公開日 2009-12-08 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Helicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substrates. Nat.Struct.Mol.Biol., 17, 2010
3FE3	Crystal structure of the kinase MARK3/Par-1: T211A-S215A double mutant 分子名称: MAP/microtubule affinity-regulating kinase 3 著者 Nugoor, C, Marx, A, Panneerselvam, S, Mandelkow, E.-M, Mandelkow, E. 登録日 2008-11-27 公開日 2008-12-16 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of the kinase MARK3/Par-1: T211A-S215A double mutant TO BE PUBLISHED
3F92	Crystal structure of ubiquitin-conjugating enzyme E2-25kDa (Huntington Interacting Protein 2) M172A mutant crystallized at pH 8.5 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BETA-MERCAPTOETHANOL, CALCIUM ION, ... 著者 Wilson, R.C, Hughes, R.C, Flatt, J.W, Meehan, E.J, Ng, J.D, Twigg, P.D. 登録日 2008-11-13 公開日 2008-11-25 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Structure of full-length ubiquitin-conjugating enzyme E2-25K (huntingtin-interacting protein 2). Acta Crystallogr.,Sect.F, 65, 2009
3E46	Crystal structure of ubiquitin-conjugating enzyme E2-25kDa (Huntington interacting protein 2) M172A mutant 分子名称: CALCIUM ION, Ubiquitin-conjugating enzyme E2-25 kDa 著者 Hughes, R.C, Wilson, R.C, Flatt, J.W, Meehan, E.J, Ng, J.D, Twigg, P.D. 登録日 2008-08-09 公開日 2008-08-26 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Structure of full-length ubiquitin-conjugating enzyme E2-25K (huntingtin-interacting protein 2). Acta Crystallogr.,Sect.F, 65, 2009
2R0I	Crystal structure of a kinase MARK2/Par-1 mutant 分子名称: Serine/threonine-protein kinase MARK2 著者 Panneerselvam, S, Marx, A, Mandelkow, E.-M, Mandelkow, E. 登録日 2007-08-20 公開日 2008-08-26 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.202 Å) 主引用文献 Crystal structure of a kinase MARK2/Par-1 mutant To be Published
2JUJ	Solution Structure of the UBA domain from c-Cbl 分子名称: E3 ubiquitin-protein ligase CBL 著者 Zhou, Z.R, Hong, J, Lin, D.H, Hu, H.Y. 登録日 2007-08-30 公開日 2008-07-15 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Differential Ubiquitin Binding of the UBA Domains from Human c-Cbl and Cbl-b: NMR Structural and Biochemical Insights. Protein Sci., 2008
2JY6	Solution structure of the complex of ubiquitin and ubiquilin 1 UBA domain 分子名称: Ubiquilin-1, Ubiquitin protein 著者 Zhang, D, Raasi, S, Fushman, D. 登録日 2007-12-06 公開日 2008-03-18 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Affinity makes the difference: nonselective interaction of the UBA domain of Ubiquilin-1 with monomeric ubiquitin and polyubiquitin chains J.Mol.Biol., 377, 2008

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