5ES1
CRYSTAL STRUCTURE OF MICROTUBULE AFFINITY-REGULATING KINASE 4 CATALYTIC DOMAIN IN COMPLEX WITH A PYRAZOLOPYRIMIDINE INHIBITOR
Summary for 5ES1
Entry DOI | 10.2210/pdb5es1/pdb |
Descriptor | MAP/microtubule affinity-regulating kinase 4, ~{N}-[(1~{R},6~{R})-6-azanyl-2,2-bis(fluoranyl)cyclohexyl]-5-ethyl-4-[6-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]thiophene-2-carboxamide (3 entities in total) |
Functional Keywords | mark4 par-1 serine/threonine protein kinase11, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : Q96L34 |
Total number of polymer chains | 1 |
Total formula weight | 38092.83 |
Authors | Sack, J.S. (deposition date: 2015-11-16, release date: 2015-12-02, Last modification date: 2023-09-27) |
Primary citation | Sack, J.S.,Gao, M.,Kiefer, S.E.,Myers, J.E.,Newitt, J.A.,Wu, S.,Yan, C. Crystal structure of microtubule affinity-regulating kinase 4 catalytic domain in complex with a pyrazolopyrimidine inhibitor. Acta Crystallogr F Struct Biol Commun, 72:129-134, 2016 Cited by PubMed: 26841763DOI: 10.1107/S2053230X15024747 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
Download full validation report