5ES1
CRYSTAL STRUCTURE OF MICROTUBULE AFFINITY-REGULATING KINASE 4 CATALYTIC DOMAIN IN COMPLEX WITH A PYRAZOLOPYRIMIDINE INHIBITOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | MAP/microtubule affinity-regulating kinase 4 | polymer | 328 | 37619.4 | 1 | UniProt (Q96L34) Pfam (PF00069) Pfam (PF00627) In PDB | Homo sapiens (Human) | MAP/microtubule affinity-regulating kinase-like 1 |
| 2 | A | ~{N}-[(1~{R},6~{R})-6-azanyl-2,2-bis(fluoranyl)cyclohexyl]-5-ethyl-4-[6-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]thiophene-2-carboxamide | non-polymer | 473.5 | 1 | Chemie (5RC) | |||
| 3 | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A: 41 - 367 (UniProt: Q96L34)
| PDB | External Database | Details |
|---|---|---|
| Gly 40 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37619.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 473.5 | |
| All* | Total formula weight | 38092.8 |
