3IEC

Helicobacter pylori CagA Inhibits PAR1/MARK Family Kinases by Mimicking Host Substrates

Summary for 3IEC

Entry DOI	10.2210/pdb3iec/pdb
Descriptor	Serine/threonine-protein kinase MARK2, Cytotoxicity-associated immunodominant antigen (3 entities in total)
Functional Keywords	protein-protein complex, kinase, virulence factor, alternative promoter usage, atp-binding, cell membrane, developmental protein, differentiation, magnesium, membrane, metal-binding, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, signaling protein-toxin complex, signaling protein/toxin
Biological source	Homo sapiens (human) More
Cellular location	Cell membrane; Peripheral membrane protein: Q7KZI7
Total number of polymer chains	8
Total formula weight	201371.44
Authors	Stebbins, C.E.,Nesic, D.,Miller, M. (deposition date: 2009-07-22, release date: 2009-12-08, Last modification date: 2024-02-21)
Primary citation	Nesic, D.,Miller, M.C.,Quinkert, Z.T.,Stein, M.,Chait, B.T.,Stebbins, C.E. Helicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substrates. Nat.Struct.Mol.Biol., 17:130-132, 2010 Cited by PubMed: 19966800 DOI: 10.1038/nsmb.1705 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation