3IEC
Helicobacter pylori CagA Inhibits PAR1/MARK Family Kinases by Mimicking Host Substrates
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Serine/threonine-protein kinase MARK2 | polymer | 319 | 36919.8 | 4 | UniProt (Q7KZI7) Pfam (PF00069) Pfam (PF00627) | Homo sapiens (human) | MAP/microtubule affinity-regulating kinase 2, ELKL motif kinase, EMK1, PAR1 homolog |
| 2 | E, F, G, H (E, F, G, H) | Cytotoxicity-associated immunodominant antigen | polymer | 125 | 13423.1 | 4 | UniProt (P55980) Pfam (PF03507) | Helicobacter pylori (Campylobacter pylori) | 120 kDa protein |
| 3 | I, J, K, L, M... (A, B, C, D, E...) | water | water | 18.0 | 687 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 49 - 363 (UniProt: Q7KZI7)
E, F, G, H: 885 - 1005 (UniProt: P55980)
| PDB | External Database | Details |
|---|---|---|
| Met 45 | - | expression tag |
| Ala 46 | - | expression tag |
| Asp 47 | - | expression tag |
| Leu 48 | - | expression tag |
| Trp 146 | Arg 146 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 881 | - | expression tag |
| Pro 882 | - | expression tag |
| Val 883 | - | expression tag |
| Asp 884 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 201371.4 | |
| All* | Total formula weight | 201371.4 |
