6HJL
 
 | | Affimer:BclxL | | 分子名称: | Affimer ADB13, Bcl-2-like protein 1 | | 著者 | Miles, J.A, Trinh, C.H, Tomlinson, D.C, Wilson, A.J, Edwards, T.A. | | 登録日 | 2018-09-04 | | 公開日 | 2020-03-18 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Selective Affimers Recognize BCL-2 Family Proteins Through Non-Canonical Structural Motifs
Biorxiv, 2020
|
|
7JMT
 | | Crystal structure of schistosome BCL-2 bound to ABT-737 | | 分子名称: | 4-{4-[(4'-CHLOROBIPHENYL-2-YL)METHYL]PIPERAZIN-1-YL}-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLTHIO)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE, BCL-2 protein | | 著者 | Smith, N.A, Smith, B.J, Lee, E.F, Colman, P.M, Fairlie, W.D. | | 登録日 | 2020-08-02 | | 公開日 | 2021-02-17 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Optimization of Benzothiazole and Thiazole Hydrazones as Inhibitors of Schistosome BCL-2.
Acs Infect Dis., 7, 2021
|
|
6H1N
 | |
5C3F
 | | Crystal structure of Mcl-1 bound to BID-MM | | 分子名称: | BID-MM, GLYCEROL, Induced myeloid leukemia cell differentiation protein Mcl-1 | | 著者 | Miles, J.A, Yeo, D.J, Rowell, P, Rodriguez-Marin, S, Pask, C.M, Warriner, S.L, Edwards, T.A, Wilson, A.J. | | 登録日 | 2015-06-17 | | 公開日 | 2016-04-20 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | | 主引用文献 | Hydrocarbon constrained peptides - understanding preorganisation and binding affinity.
Chem Sci, 7, 2016
|
|
8IQM
 | | Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival proteins | | 分子名称: | Bcl2 modifying factor, Induced myeloid leukemia cell differentiation protein Mcl-1 | | 著者 | Wang, H, Guo, M, Wei, H, Chen, Y. | | 登録日 | 2023-03-16 | | 公開日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.967 Å) | | 主引用文献 | Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival Bcl-2 family proteins.
Comput Struct Biotechnol J, 21, 2023
|
|
8IGC
 | | Crystal structure of Bak bound to Bnip5 BH3 | | 分子名称: | Bcl-2 homologous antagonist/killer, Protein BNIP5 | | 著者 | Ku, B, Lim, D. | | 登録日 | 2023-02-20 | | 公開日 | 2023-09-20 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.697 Å) | | 主引用文献 | Crystal structure of Bak bound to the BH3 domain of Bnip5, a noncanonical BH3 domain-containing protein.
Proteins, 92, 2024
|
|
4S0P
 | |
5FMI
 | | Human Bak Q77L | | 分子名称: | BCL-2 HOMOLOGOUS ANTAGONIST/KILLER, ZINC ION | | 著者 | Fairlie, W.D, Lee, E.F, Smith, B.J. | | 登録日 | 2015-11-06 | | 公開日 | 2016-06-01 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.491 Å) | | 主引用文献 | Physiological Restraint of Bak by Bcl-Xl is Essential for Cell Survival.
Genes Dev., 30, 2016
|
|
5JSB
 | | Crystal structure of Mcl1-inhibitor complex | | 分子名称: | Induced myeloid leukemia cell differentiation protein Mcl-1, Mcl-1 inhibitor | | 著者 | Shen, B.W, Stoddard, B.L. | | 登録日 | 2016-05-07 | | 公開日 | 2016-11-16 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | | 主引用文献 | Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer.
Elife, 5, 2016
|
|
4S0O
 | |
4U2U
 | |
5KU9
 | | Crystal structure of MCL1 with compound 1 | | 分子名称: | (3~{S})-3-azanyl-4-(4-bromophenyl)-~{N}-[(3~{S})-1-[2-[[(2~{R})-1-(3,4-dichlorophenyl)-4-(methylamino)-4-oxidanylidene-butan-2-yl]amino]-2-oxidanylidene-ethyl]-2-oxidanylidene-4,5-dihydro-3~{H}-1-benzazepin-3-yl]butanamide, Induced myeloid leukemia cell differentiation protein Mcl-1, SODIUM ION | | 著者 | Ferguson, A.D. | | 登録日 | 2016-07-13 | | 公開日 | 2017-01-11 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors.
ACS Med Chem Lett, 8, 2017
|
|
5IEZ
 | |
5IF4
 | | Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) inhibitors using Structure-Based Design | | 分子名称: | 4-{8-chloro-11-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1-oxo-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)-4,5-dihydro-1H-[1,4]diazepino[1,2-a]indol-2(3H)-yl}-1-methyl-1H-indole-6-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1 | | 著者 | Zhao, B. | | 登録日 | 2016-02-25 | | 公開日 | 2017-01-18 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.392 Å) | | 主引用文献 | Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors.
FEBS Lett., 591, 2017
|
|
4G35
 | | Mcl-1 in complex with a biphenyl cross-linked Noxa peptide. | | 分子名称: | 4,4'-bis(bromomethyl)biphenyl, Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Noxa BH3 peptide (cysteine-mediated cross-linked) | | 著者 | Drake, E, Edwardraja, S, Lin, Q, Gulick, A.M. | | 登録日 | 2012-07-13 | | 公開日 | 2012-12-05 | | 最終更新日 | 2013-06-26 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Rational design of proteolytically stable, cell-permeable peptide-based selective Mcl-1 inhibitors.
J.Am.Chem.Soc., 134, 2012
|
|
6EB6
 | | Crystal structure of BAX W139A monomer | | 分子名称: | Apoptosis regulator BAX, FORMIC ACID | | 著者 | Robin, A.Y. | | 登録日 | 2018-08-05 | | 公開日 | 2019-04-10 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.023 Å) | | 主引用文献 | BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association.
Cell Rep, 27, 2019
|
|
6FBX
 | |
6FS1
 | | MCL1 in complex with an indole acid ligand | | 分子名称: | 1,2-ETHANEDIOL, 7-[3-[(1,5-dimethylpyrazol-3-yl)methylsulfanylmethyl]-1,5-dimethyl-pyrazol-4-yl]-3-(3-naphthalen-1-yloxypropyl)-1~{H}-indole-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1 | | 著者 | Kasmirski, S, Hargreaves, D. | | 登録日 | 2018-02-18 | | 公開日 | 2018-12-26 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia.
Nat Commun, 9, 2018
|
|
6FS2
 | | MCL1 in complex with indole acid ligand | | 分子名称: | 7-(2-methylphenyl)-3-[3-(5,6,7,8-tetrahydronaphthalen-1-yloxy)propyl]-1~{H}-indole-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1 | | 著者 | Hargreaves, D. | | 登録日 | 2018-02-18 | | 公開日 | 2018-12-26 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia.
Nat Commun, 9, 2018
|
|
6FS0
 | |
4HW2
 | |
4HW3
 | |
4HW4
 | |
1WSX
 | | Solution structure of MCL-1 | | 分子名称: | myeloid cell leukemia sequence 1 | | 著者 | Day, C.L, Chen, L, Richardson, S.J, Harrison, P.J, Huang, D.C, Hinds, M.G. | | 登録日 | 2004-11-12 | | 公開日 | 2004-11-23 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution Structure of Prosurvival Mcl-1 and Characterization of Its Binding by Proapoptotic BH3-only Ligands
J.Biol.Chem., 280, 2005
|
|
2YV6
 | | Crystal structure of human Bcl-2 family protein Bak | | 分子名称: | Bcl-2 homologous antagonist/killer, SULFATE ION | | 著者 | Wang, H, Kishishita, S, Murayama, K, Takemoto, C, Terada, T, Shirouzu, M, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2007-04-09 | | 公開日 | 2008-04-15 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Novel dimerization mode of the human Bcl-2 family protein Bak, a mitochondrial apoptosis regulator.
J.Struct.Biol., 166, 2009
|
|
