PDB: 167 件ウェブページステータス検索Chemie searchBIRD

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7JP2	Crystal structure of TP0037 from Treponema pallidum, a D-lactate dehydrogenase 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, D-lactate dehydrogenase 著者 Brautigam, C.A, Deka, R.K, Norgard, M.V. 登録日 2020-08-07 公開日 2020-09-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.38 Å) 主引用文献 Biophysical and Biochemical Characterization of TP0037, a d-Lactate Dehydrogenase, Supports an Acetogenic Energy Conservation Pathway in Treponema pallidum. Mbio, 11, 2020
5Z20	The ternary structure of D-lactate dehydrogenase from Pseudomonas aeruginosa with NADH and oxamate 分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, D-lactate dehydrogenase (Fermentative), DI(HYDROXYETHYL)ETHER, ... 著者 Furukawa, N, Miyanaga, A, Nakajima, M, Taguchi, H. 登録日 2017-12-28 公開日 2018-09-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural Basis of Sequential Allosteric Transitions in Tetrameric d-Lactate Dehydrogenases from Three Gram-Negative Bacteria. Biochemistry, 57, 2018
8HPG	Crystal structure of phenylpyruvate reductase from Lactobacillus sp. CGMCC 9967 分子名称: Phenylpyruvate reductase 著者 Yang, J.H, Song, W. 登録日 2022-12-12 公開日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.895 Å) 主引用文献 One-Pot Biocatalytic Transformation of L-DOPA to D-Danshensu To Be Published
5Z21	The ternary structure of D-lactate dehydrogenase from Fusobacterium nucleatum with NADH and oxamate 分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, D-lactate dehydrogenase, OXAMIC ACID 著者 Furukawa, N, Miyanaga, A, Nakajima, M, Taguchi, H. 登録日 2017-12-28 公開日 2018-09-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural Basis of Sequential Allosteric Transitions in Tetrameric d-Lactate Dehydrogenases from Three Gram-Negative Bacteria. Biochemistry, 57, 2018
4LCE	CtBP1 in complex with substrate MTOB 分子名称: 4-(METHYLSULFANYL)-2-OXOBUTANOIC ACID, C-terminal-binding protein 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Hilbert, B.J, Schiffer, C.A, Royer Jr, W.E. 登録日 2013-06-21 公開日 2014-03-19 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design. Febs Lett., 588, 2014
4LCJ	CtBP2 in complex with substrate MTOB 分子名称: 4-(METHYLSULFANYL)-2-OXOBUTANOIC ACID, C-terminal-binding protein 2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Hilbert, B.J, Schiffer, C.A, Royer Jr, W.E. 登録日 2013-06-21 公開日 2014-03-19 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.86 Å) 主引用文献 Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design. Febs Lett., 588, 2014
2CUK	Crystal structure of TT0316 protein from Thermus thermophilus HB8 分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, glycerate dehydrogenase/glyoxylate reductase 著者 Lokanath, N.K, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-05-26 公開日 2006-08-15 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of TT0316 protein from Thermus thermophilus HB8 To be Published
2D0I	Crystal Structure PH0520 protein from Pyrococcus horikoshii OT3 分子名称: dehydrogenase 著者 Lokanath, N.K, Terao, Y, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-08-02 公開日 2006-02-02 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Crystal Structure PH0520 protein from Pyrococcus horikoshii OT3 To be Published
2YQ4	Crystal Structure of D-isomer specific 2-hydroxyacid dehydrogenase from Lactobacillus delbrueckii ssp. bulgaricus 分子名称: D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE 著者 Holton, S.J, Anandhakrishnan, M, Geerlof, A, Wilmanns, M. 登録日 2012-11-05 公開日 2012-11-21 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3.45 Å) 主引用文献 Structural Characterization of D-Isomer Specific 2-Hydroxyacid Dehydrogenase from Lactobacillus Delbrueckii Ssp. Bulgaricus J.Struct.Biol., 181, 2013
7CVP	The Crystal Structure of human PHGDH from Biortus. 分子名称: D-3-phosphoglycerate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Wang, F, Lv, Z, Cheng, W, Lin, D, Miao, Q, Huang, Y. 登録日 2020-08-26 公開日 2020-09-09 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The Crystal Structure of human PHGDH from Biortus. To Be Published
6PLG	Crystal structure of human PHGDH complexed with Compound 15 分子名称: (2S)-(4-{3-[(4,5-dichloro-1-methyl-1H-indole-2-carbonyl)amino]oxetan-3-yl}phenyl)(pyridin-3-yl)acetic acid, D-3-phosphoglycerate dehydrogenase, D-MALATE 著者 Olland, A, Lakshminarasimhan, D, White, A, Suto, R.K. 登録日 2019-06-30 公開日 2019-07-24 最終更新日 2019-09-04 実験手法 X-RAY DIFFRACTION (2.93 Å) 主引用文献 Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells. Bioorg.Med.Chem.Lett., 29, 2019
2WWR	Crystal Structure of Human Glyoxylate Reductase Hydroxypyruvate Reductase 分子名称: GLYOXYLATE REDUCTASE/HYDROXYPYRUVATE REDUCTASE, MAGNESIUM ION 著者 Booth, M.P.S, Conners, R, Rumsby, G, Brady, R.L. 登録日 2009-10-26 公開日 2010-10-13 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.82 Å) 主引用文献 Structural Basis of Substrate Specificity in Human Glyoxylate Reductase/Hydroxypyruvate Reductase. J.Mol.Biol., 360, 2006
5N53	Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with N-(3-chloro-4-methoxyphenyl) acetamide 分子名称: D-3-phosphoglycerate dehydrogenase, ~{N}-(3-chloranyl-4-methoxy-phenyl)ethanamide 著者 Unterlass, J.E, Basle, A, Blackburn, T.J, Tucker, J, Cano, C, Noble, M.E.M, Curtin, N.J. 登録日 2017-02-12 公開日 2017-04-05 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer. Oncotarget, 9, 2018
8ATI	Human CtBP2(31-364) in complex with RAI2 peptide(315-322) 分子名称: DI(HYDROXYETHYL)ETHER, Isoform 2 of C-terminal-binding protein 2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... 著者 Mullapudi, E, Goradia, N, Wilmanns, M. 登録日 2022-08-23 公開日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Human CtBP2(31-364) in complex with RAI2 peptide(315-322) To Be Published
8ARI	Cryo-EM structure of human CtBP1/RAI2(303-362) delta(331-341) filament 分子名称: C-terminal-binding protein 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Retinoic acid-induced protein 2 著者 Mullapudi, E, Goradia, N, Wilmanns, M. 登録日 2022-08-16 公開日 2023-08-23 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Cryo-EM structure of human CtBP1/RAI2(303-362) delta(331-341) filament To Be Published
5N6C	Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with NAD and L-Tartrate 分子名称: D-3-phosphoglycerate dehydrogenase, L(+)-TARTARIC ACID, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Unterlass, J.E, Basle, A, Tucker, J, Cano, C, Noble, M.E.M, Curtin, N.J. 登録日 2017-02-14 公開日 2017-11-22 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH). Oncotarget, 8, 2017
1PSD	THE ALLOSTERIC LIGAND SITE IN THE VMAX-TYPE COOPERATIVE ENZYME PHOSPHOGLYCERATE DEHYDROGENASE 分子名称: D-3-PHOSPHOGLYCERATE DEHYDROGENASE (PHOSPHOGLYCERATE DEHYDROGENASE), NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SERINE 著者 Schuller, D.J, Grant, G.A, Banaszak, L.J. 登録日 1995-05-02 公開日 1995-07-31 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 The allosteric ligand site in the Vmax-type cooperative enzyme phosphoglycerate dehydrogenase. Nat.Struct.Biol., 2, 1995
6PEX	An aldo keto reductase with 2-keto- L-gulonate reductase activity 分子名称: aldo keto reductase 著者 Yong, J, Crystal, S, Robert, D.H, John, B.B. 登録日 2019-06-21 公開日 2019-09-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.581 Å) 主引用文献 An aldo-keto reductase with 2-keto-l-gulonate reductase activity functions in l-tartaric acid biosynthesis from vitamin C inVitis vinifera. J.Biol.Chem., 294, 2019
6PLF	Crystal structure of human PHGDH complexed with Compound 1 分子名称: 1,2-ETHANEDIOL, 4-{(1S)-1-[(5-chloro-6-{[(5S)-2-oxo-1,3-oxazolidin-5-yl]methoxy}-1H-indole-2-carbonyl)amino]-2-hydroxyethyl}benzoic acid, D-3-phosphoglycerate dehydrogenase 著者 Olland, A, Lakshminarasimhan, D, White, A, Suto, R.K. 登録日 2019-06-30 公開日 2019-07-24 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells. Bioorg.Med.Chem.Lett., 29, 2019
1SC6	Crystal Structure of W139G D-3-Phosphoglycerate dehydrogenase complexed with NAD+ 分子名称: D-3-phosphoglycerate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Bell, J.K, Grant, G.A, Banaszak, L.J. 登録日 2004-02-11 公開日 2005-02-22 最終更新日 2021-10-27 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Multiconformational states in phosphoglycerate dehydrogenase Biochemistry, 43, 2004
4S1V	Crystal structure of phosphoglycerate oxidoreductase from Vibrio Cholerae o395 分子名称: D-3-phosphoglycerate dehydrogenase-related protein 著者 Tarique, K.F, Rehman, S.A.A, Devi, S, Gourinath, S. 登録日 2015-01-15 公開日 2015-01-28 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Structure of Phosphoglycerate Oxidoreductase from Vibrio Cholerae O395 To be Published
5NZQ	Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with 3-(1,3-oxazol-5-yl)aniline. 分子名称: 3-(1,3-oxazol-5-yl)aniline, D-3-phosphoglycerate dehydrogenase 著者 Unterlass, J.E, Basle, A, Blackburn, T.J, Tucker, J, Cano, C, Noble, M.E.M, Curtin, N.J. 登録日 2017-05-14 公開日 2017-06-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer. Oncotarget, 9, 2018
4U6S	CtBP1 in complex with substrate phenylpyruvate 分子名称: 3-PHENYLPYRUVIC ACID, C-terminal-binding protein 1, CALCIUM ION, ... 著者 Hilbert, B.J, Morris, B.L, Ellis, K.C, Paulsen, J.L, Schiffer, C.A, Grossman, S.R, Royer Jr, W.E. 登録日 2014-07-29 公開日 2015-02-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure-Guided Design of a High Affinity Inhibitor to Human CtBP. Acs Chem.Biol., 10, 2015
4U6Q	CtBP1 bound to inhibitor 2-(hydroxyimino)-3-phenylpropanoic acid 分子名称: (2E)-2-(hydroxyimino)-3-phenylpropanoic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, C-terminal-binding protein 1, ... 著者 Hilbert, B.J, Morris, B.L, Ellis, K.C, Paulsen, J.L, Schiffer, C.A, Grossman, S.R, Royer Jr, W.E. 登録日 2014-07-29 公開日 2015-02-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure-Guided Design of a High Affinity Inhibitor to Human CtBP. Acs Chem.Biol., 10, 2015
8BXX	Crystal structure of formate dehydrogenase FDH2 enzyme from Granulicella mallensis MP5ACTX8 in complex with NAD and azide. 分子名称: 1,2-ETHANEDIOL, AZIDE ION, Formate dehydrogenase, ... 著者 Robescu, M.S, Rubini, R, Filippini, F, Bergantino, B, Cendron, L. 登録日 2022-12-10 公開日 2023-01-18 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 From the amelioration of a NADP+-dependent formate dehydrogenase to the discovery of a new enzyme: round trip from theory to practice ChemCatChem, 2020

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