PDB: 76 件ウェブページステータス検索Chemie searchBIRD

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2V27	Structure of the cold active phenylalanine hydroxylase from Colwellia psychrerythraea 34H 分子名称: FE (III) ION, PHENYLALANINE HYDROXYLASE, SULFATE ION 著者 Leiros, H.-K.S, Pey, A.L, Innselset, M, Moe, E, Leiros, I, Steen, I.H, Martinez, A. 登録日 2007-06-03 公開日 2007-06-19 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structure of Phenylalanine Hydroxylase from Colwellia Psychrerythraea 34H, a Monomeric Cold Active Enzyme with Local Flexibility Around the Active Site and High Overall Stability. J.Biol.Chem., 282, 2007
1TG2	Crystal structure of phenylalanine hydroxylase A313T mutant with 7,8-dihydrobiopterin bound 分子名称: 2-AMINO-6-(1,2-DIHYDROXY-PROPYL)-7,8-DIHYDRO-6H-PTERIDIN-4-ONE, FE (III) ION, Phenylalanine-4-hydroxylase 著者 Erlandsen, H, Pey, A.L, Gamez, A, Perez, B, Desviat, L.R, Aguado, C, Koch, R, Surendran, S, Tyring, S, Matalon, R, Scriver, C.R, Ugarte, M, Martinez, A, Stevens, R.C. 登録日 2004-05-28 公開日 2004-11-30 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations. Proc.Natl.Acad.Sci.Usa, 101, 2004
3TK2	Crystallographic structure of phenylalanine hydroxylase from Chromobacterium violaceum cocrystallized with phenylalanine in a site distal to the active site 分子名称: COBALT (II) ION, PHENYLALANINE, Phenylalanine-4-hydroxylase 著者 Ronau, J.A, Abu-Omar, M.M, Das, C. 登録日 2011-08-25 公開日 2012-09-05 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 An additional substrate binding site in a bacterial phenylalanine hydroxylase. Eur.Biophys.J., 42, 2013
3TK4	Crystal structure of phenylalanine hydroxylase from Chromobacterium violaceum bound to cobalt 分子名称: COBALT (II) ION, Phenylalanine-4-hydroxylase 著者 Ronau, J.A, Abu-Omar, M.M, Das, C. 登録日 2011-08-25 公開日 2012-09-05 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 An additional substrate binding site in a bacterial phenylalanine hydroxylase. Eur.Biophys.J., 42, 2013
3E2T	The catalytic domain of chicken tryptophan hydroxylase 1 with bound tryptophan 分子名称: FE (III) ION, IMIDAZOLE, SULFATE ION, ... 著者 Windahl, M.S, Petersen, C.R, Christensen, H.E.C, Harris, P. 登録日 2008-08-06 公開日 2008-11-04 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of tryptophan hydroxylase with bound amino acid substrate Biochemistry, 47, 2008
5J6D	Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-[(N-{[2-(3-methoxyphenoxy)-6-(piperidin-1-yl)phenyl]methyl}carbamimidoyl)carbamoyl]-L-phenylalanine, FE (III) ION, ... 著者 Stein, A.J, Goldberg, D.R, De Lombaert, S. 登録日 2016-04-04 公開日 2016-05-25 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors. Bioorg.Med.Chem.Lett., 26, 2016
5JK5	Phenylalanine hydroxylase from dictyostelium - BH2 complex 分子名称: 7,8-DIHYDROBIOPTERIN, FE (III) ION, PIPERAZINE-N,N'-BIS(2-ETHANESULFONIC ACID), ... 著者 Zhuang, N, Lee, K.H. 登録日 2016-04-26 公開日 2017-04-26 実験手法 X-RAY DIFFRACTION (2.071 Å) 主引用文献 Phenylalanine hydroxylase from dictyostelium - BH2 complex To Be Published
5JK8	Phenylalanine hydroxylase from dictyostelium - BH2, norleucine complex 分子名称: 7,8-DIHYDROBIOPTERIN, FE (III) ION, NORLEUCINE, ... 著者 Zhuang, N, Lee, K.H. 登録日 2016-04-26 公開日 2017-05-03 実験手法 X-RAY DIFFRACTION (2.394 Å) 主引用文献 Phenylalanine hydroxylase from dictyostelium - BH2, norleucine complex To Be Published
5JK6	Phenylalanine hydroxylase from dictyostelium - apo form 分子名称: FE (III) ION, PIPERAZINE-N,N'-BIS(2-ETHANESULFONIC ACID), Phenylalanine-4-hydroxylase 著者 Zhuang, N, Lee, K.H. 登録日 2016-04-26 公開日 2017-04-26 実験手法 X-RAY DIFFRACTION (2.072 Å) 主引用文献 Phenylalanine hydroxylase from dictyostelium - apo form To Be Published
6ZZU	Partial structure of the substrate-free tyrosine hydroxylase (apo-TH). 分子名称: FE (III) ION, Tyrosine 3-monooxygenase 著者 Bueno-Carrasco, M.T, Cuellar, J, Santiago, C, Valpuesta, J.M, Martinez, A, Flydal, M.I. 登録日 2020-08-05 公開日 2021-11-17 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. Nat Commun, 13, 2022
3HFB	Crystal structure of human tryoptophan hydroxylase type 1 with LP-534193 分子名称: 4-(5-{[(2'-methylbiphenyl-2-yl)methyl]amino}pyrazin-2-yl)-L-phenylalanine, FE (III) ION, Tryptophan 5-hydroxylase 1 著者 Tari, L.W, Swanson, R.V, Hunter, M.J. 登録日 2009-05-11 公開日 2010-04-21 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis. Curr Chem Genomics, 4, 2010
3HF6	Crystal structure of human tryptophan hydroxylase type 1 with bound LP-521834 and FE 分子名称: 4-(4-amino-6-{[(1R)-1-naphthalen-2-ylethyl]amino}-1,3,5-triazin-2-yl)-L-phenylalanine, FE (III) ION, Tryptophan 5-hydroxylase 1 著者 Tari, L.W, Swanson, R.V, Hunter, M.J. 登録日 2009-05-11 公開日 2009-11-24 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis Curr Chem Genomics, 4, 2010
3HF8	Crystal structure of human tryoptophan hydroxylase type 1 with bound LP-533401 and Fe 分子名称: 4-{2-amino-6-[(1R)-2,2,2-trifluoro-1-(3'-fluorobiphenyl-4-yl)ethoxy]pyrimidin-4-yl}-L-phenylalanine, FE (III) ION, Tryptophan 5-hydroxylase 1 著者 Tari, L.W, Swanson, R.V, Hunter, M.J. 登録日 2009-05-11 公開日 2010-04-21 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis. Curr Chem Genomics, 4, 2010
4Q3Y	Crystal structure of C. violaceum phenylalanine hydroxylase D139A mutation 分子名称: COBALT (II) ION, Phenylalanine-4-hydroxylase 著者 Ronau, J.A, Abu-Omar, M.M, Das, C. 登録日 2014-04-12 公開日 2015-02-18 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 A conserved acidic residue in phenylalanine hydroxylase contributes to cofactor affinity and catalysis. Biochemistry, 53, 2014
4Q3Z	Crystal structure of C. violaceum phenylalanine hydroxylase D139K mutation 分子名称: COBALT (II) ION, Phenylalanine-4-hydroxylase 著者 Ronau, J.A, Abu-Omar, M.M, Das, C. 登録日 2014-04-12 公開日 2015-02-18 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 A conserved acidic residue in phenylalanine hydroxylase contributes to cofactor affinity and catalysis. Biochemistry, 53, 2014
4Q3W	Crystal structure of C. violaceum phenylalanine hydroxylase D139E mutation 分子名称: 1,2-ETHANEDIOL, COBALT (II) ION, Phenylalanine-4-hydroxylase 著者 Ronau, J.A, Abu-Omar, M.M, Das, C. 登録日 2014-04-12 公開日 2015-02-18 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 A conserved acidic residue in phenylalanine hydroxylase contributes to cofactor affinity and catalysis. Biochemistry, 53, 2014
4PAH	HUMAN PHENYLALANINE HYDROXYLASE CATALYTIC DOMAIN DIMER WITH BOUND NOR-ADRENALINE INHIBITOR 分子名称: FE (III) ION, L-NOREPINEPHRINE, PHENYLALANINE HYDROXYLASE 著者 Erlandsen, H, Flatmark, T, Stevens, R.C. 登録日 1998-08-20 公開日 1999-04-27 最終更新日 2013-02-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystallographic analysis of the human phenylalanine hydroxylase catalytic domain with bound catechol inhibitors at 2.0 A resolution. Biochemistry, 37, 1998
4Q3X	Crystal structure of C. violaceum phenylalanine hydroxylase D139N mutation 分子名称: COBALT (II) ION, Phenylalanine-4-hydroxylase 著者 Ronau, J.A, Abu-Omar, M.M, Das, C. 登録日 2014-04-12 公開日 2015-02-18 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 A conserved acidic residue in phenylalanine hydroxylase contributes to cofactor affinity and catalysis. Biochemistry, 53, 2014
7ZIH	Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor AG-01-128 分子名称: 8-(1~{H}-benzimidazol-2-ylmethyl)-3-ethyl-7-(phenylmethyl)purine-2,6-dione, DI(HYDROXYETHYL)ETHER, FE (III) ION, ... 著者 Schuetz, A, Gogolin, A, Pfeifer, J, Mallow, K, Nazare, M, Specker, E, Heinemann, U. 登録日 2022-04-08 公開日 2022-09-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.46890831 Å) 主引用文献 Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 65, 2022
7ZIK	Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor LP533401 分子名称: (2~{R})-2-azanyl-3-[4-[2-azanyl-6-[(1~{R})-1-[4-chloranyl-2-(3-methylpyrazol-1-yl)phenyl]-2,2,2-tris(fluoranyl)ethoxy]pyrimidin-4-yl]phenyl]propanoic acid, FE (III) ION, Tryptophan 5-hydroxylase 1 著者 Schuetz, A, Heinemann, U. 登録日 2022-04-08 公開日 2022-09-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.58925915 Å) 主引用文献 Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 65, 2022
7ZII	Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-05-193 分子名称: 8-(5~{H}-[1,3]dioxolo[4,5-f]benzimidazol-6-ylmethyl)-7-(phenylmethyl)-3-propyl-purine-2,6-dione, FE (III) ION, GLYCEROL, ... 著者 Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. 登録日 2022-04-08 公開日 2022-09-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.6280005 Å) 主引用文献 Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 65, 2022
7ZIJ	Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-05-080 分子名称: 8-(1~{H}-benzimidazol-2-ylmethyl)-3-cyclopropyl-7-(phenylmethyl)purine-2,6-dione, FE (III) ION, Tryptophan 5-hydroxylase 1 著者 Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. 登録日 2022-04-08 公開日 2022-09-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.94678366 Å) 主引用文献 Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 65, 2022
7ZIG	Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-05-060 分子名称: (2~{R})-2-azanyl-5-[[2-[[3-methyl-2,6-bis(oxidanylidene)-7-(phenylmethyl)purin-8-yl]methyl]-1~{H}-benzimidazol-5-yl]amino]-5-oxidanylidene-pentanoic acid, FE (III) ION, Tryptophan 5-hydroxylase 1 著者 Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. 登録日 2022-04-08 公開日 2022-09-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.808885 Å) 主引用文献 Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 65, 2022
7ZIF	Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-480 分子名称: (2R)-2-azanyl-5-[[2-[3-methyl-2,6-bis(oxidanylidene)-7-(phenylmethyl)purin-8-yl]sulfanyl-3H-benzimidazol-5-yl]amino]-5-oxidanylidene-pentanoic acid, FE (III) ION, GLYCEROL, ... 著者 Schuetz, A, Ziebart, N, Weise, M, Mallow, K, Pfeifer, J, Nazare, M, Specker, E, Heinemann, U. 登録日 2022-04-08 公開日 2022-09-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.86859715 Å) 主引用文献 Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 65, 2022
8CJI	Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor KM-07-052 分子名称: FE (III) ION, Tryptophan 5-hydroxylase 1, methyl (2~{S})-2-azanyl-3-[[3-[[3-ethyl-2,6-bis(oxidanylidene)-8-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-ylmethyl)purin-7-yl]methyl]phenyl]carbonylamino]propanoate 著者 Schuetz, A, Mallow, K, Nazare, M, Specker, E, Heinemann, U. 登録日 2023-02-13 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structure-Based Design of Xanthine-Imidazopyridines and -Imidazothiazoles as Highly Potent and In Vivo Efficacious Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 66, 2023

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