6R06
 
 | | T. CRUZI FPPS IN COMPLEX WITH (3S,4S)-4-(3,4-dimethylphenoxy)-1-(prop-2-yn-1-yl)piperidin-3-ol | | 分子名称: | (3~{S},4~{S})-4-(3,4-dimethylphenoxy)-1-prop-2-ynyl-piperidin-3-ol, ACETATE ION, Farnesyl diphosphate synthase, ... | | 著者 | Petrick, J.K, Muenzker, L, Schleberger, C, Wolfgang, J. | | 登録日 | 2019-03-12 | | 公開日 | 2020-04-01 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.559 Å) | | 主引用文献 | Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery
Thesis, 2019
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8F8K
 | | The structure of Rv2173 from M. tuberculosis with IPP bound | | 分子名称: | (2E,6E)-farnesyl diphosphate synthase, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ACETATE ION, ... | | 著者 | Johnston, J.M, Allison, T.M, Titterington, J, Beasley, C.P.H. | | 登録日 | 2022-11-22 | | 公開日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The structure of Rv2173 from M. tuberculosis in APO-, IPP-, and DMAP-bound forms.
To be Published
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8F8F
 | | The structure of Rv2173 from M. tuberculosis (APO form) | | 分子名称: | (2E,6E)-farnesyl diphosphate synthase, GLYCEROL, MAGNESIUM ION | | 著者 | Johnston, J.M, Allison, T.M, Titterington, J. | | 登録日 | 2022-11-22 | | 公開日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The structure of Rv2173 from M. tuberculosis in APO-, IPP-, and DMAP-bound forms.
To be Published
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8F8L
 | | The structure of Rv2173 from M. tuberculosis with DMAP bound | | 分子名称: | (2E,6E)-farnesyl diphosphate synthase, CALCIUM ION, DIMETHYLALLYL DIPHOSPHATE, ... | | 著者 | Johnston, J.M, Allison, T.M, Titterington, J. | | 登録日 | 2022-11-22 | | 公開日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The structure of Rv2173 from M. tuberculosis in APO-, IPP-, and DMAP-bound forms.
To be Published
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6V0K
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6W7I
 | | LmFPPS mutant T164W in complex with 476A, IPP & Ca | | 分子名称: | 3-butyl-1-(2,2-diphosphonoethyl)pyridinium, ACETATE ION, CALCIUM ION, ... | | 著者 | Maheshwari, S, Kim, Y.S, Aripirala, S, Gabelli, S.B. | | 登録日 | 2020-03-19 | | 公開日 | 2020-10-07 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Identifying Structural Determinants of Product Specificity in Leishmania major Farnesyl Diphosphate Synthase.
Biochemistry, 59, 2020
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6VJC
 | | LmFPPS mutant T164Y in complex with 476A, IPP & Ca | | 分子名称: | 3-butyl-1-(2,2-diphosphonoethyl)pyridinium, ACETATE ION, CALCIUM ION, ... | | 著者 | Maheshwari, S, Kim, Y.S, Aripirala, S, Gabelli, S.B. | | 登録日 | 2020-01-15 | | 公開日 | 2020-11-25 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Identifying Structural Determinants of Product Specificity in Leishmania major Farnesyl Diphosphate Synthase.
Biochemistry, 59, 2020
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5XN6
 | | Heterodimer crystal structure of geranylgeranyl diphosphate synthases 1 with GGPPS Recruiting Protein(OsGRP) from Oryza sativa | | 分子名称: | Os02g0668100 protein, Os07g0580900 protein | | 著者 | Wang, C, Zhou, F, Lu, S, Zhang, P. | | 登録日 | 2017-05-18 | | 公開日 | 2017-06-28 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.598 Å) | | 主引用文献 | A recruiting protein of geranylgeranyl diphosphate synthase controls metabolic flux toward chlorophyll biosynthesis in rice
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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4WK5
 | | Crystal structure of a Isoprenoid Synthase family member from Thermotoga neapolitana DSM 4359, target EFI-509458 | | 分子名称: | Geranyltranstransferase | | 著者 | Toro, R, Bhosle, R, Vetting, M.W, Al Obaidi, N.F, Morisco, L.L, Wasserman, S.R, Sojitra, S, Stead, M, Washington, E, Scott Glenn, A, Chowdhury, S, Evans, B, Hillerich, B, Love, J, Seidel, R.D, Whalen, K.L, Gerlt, J.A, Poulter, C.D, Almo, S.C, Enzyme Function Initiative (EFI) | | 登録日 | 2014-10-01 | | 公開日 | 2014-11-19 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Crystal structure of a Isoprenoid Synthase family member from Thermotoga neapolitana DSM 4359, target EFI-509458
To be published
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5XN5
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2J1O
 | | Geranylgeranyl diphosphate synthase from Sinapis alba | | 分子名称: | GERANYLGERANYL PYROPHOSPHATE SYNTHETASE, GLYCEROL | | 著者 | Kloer, D.P, Welsch, R, Beyer, P, Schulz, G.E. | | 登録日 | 2006-08-15 | | 公開日 | 2007-01-02 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure and Reaction Geometry of Geranylgeranyl Diphosphate Synthase from Sinapis Alba.
Biochemistry, 45, 2006
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2J1P
 | | Geranylgeranyl diphosphate synthase from Sinapis alba in complex with GGPP | | 分子名称: | BETA-MERCAPTOETHANOL, GERANYLGERANYL DIPHOSPHATE, GERANYLGERANYL PYROPHOSPHATE SYNTHETASE, ... | | 著者 | Kloer, D.P, Welsch, R, Beyer, P, Schulz, G.E. | | 登録日 | 2006-08-15 | | 公開日 | 2007-01-02 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structure and Reaction Geometry of Geranylgeranyl Diphosphate Synthase from Sinapis Alba.
Biochemistry, 45, 2006
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4XQR
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6N82
 | | Crystal structure of human FPPS in complex with an allosteric inhibitor YF-02037 | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Farnesyl pyrophosphate synthase, ... | | 著者 | Park, J, Schilling, M.A, Berghuis, A.M. | | 登録日 | 2018-11-28 | | 公開日 | 2019-11-06 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Chirality-Driven Mode of Binding of alpha-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS).
J.Med.Chem., 62, 2019
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4XQT
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4XQS
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6N7Z
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5YGI
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6N83
 | | Crystal structure of human FPPS in complex with an allosteric inhibitor YF-02037 | | 分子名称: | CHLORIDE ION, Farnesyl pyrophosphate synthase, PHOSPHATE ION, ... | | 著者 | Park, J, Schilling, M.A, Berghuis, A.M. | | 登録日 | 2018-11-28 | | 公開日 | 2019-11-06 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Chirality-Driven Mode of Binding of alpha-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS).
J.Med.Chem., 62, 2019
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7BUX
 | | Eucommia ulmoides FPS1 | | 分子名称: | FPS2 | | 著者 | Kajiura, H, Yoshizawa, T, Tokumoto, Y, Suzuki, N, Takeno, S, Takeno, K.J, Yamashita, T, Tanaka, S, Kaneko, Y, Fujiyama, K, Matsumura, H, Nakazawa, Y. | | 登録日 | 2020-04-08 | | 公開日 | 2021-02-17 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure-function studies of ultrahigh molecular weight isoprenes provide key insights into their biosynthesis.
Commun Biol, 4, 2021
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7BUW
 | | Eucommia ulmoides TPT3 mutant -C94Y/A95F | | 分子名称: | FPS3 | | 著者 | Kajiura, H, Yoshizawa, T, Tokumoto, Y, Suzuki, N, Takeno, S, Takeno, K.J, Yamashita, T, Tanaka, S, Kaneko, Y, Fujiyama, K, Matsumura, H, Nakazawa, Y. | | 登録日 | 2020-04-08 | | 公開日 | 2021-02-17 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structure-function studies of ultrahigh molecular weight isoprenes provide key insights into their biosynthesis.
Commun Biol, 4, 2021
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7BUV
 | | Eucommia ulmoides TPT3, crystal form 2 | | 分子名称: | FPS3 | | 著者 | Kajiura, H, Yoshizawa, T, Tokumoto, Y, Suzuki, N, Takeno, S, Takeno, K.J, Yamashita, T, Tanaka, S, Kaneko, Y, Fujiyama, K, Matsumura, H, Nakazawa, Y. | | 登録日 | 2020-04-08 | | 公開日 | 2021-02-17 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structure-function studies of ultrahigh molecular weight isoprenes provide key insights into their biosynthesis.
Commun Biol, 4, 2021
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7BUU
 | | Eucommia ulmoides TPT3, crystal form 1 | | 分子名称: | FPS3 | | 著者 | Kajiura, H, Yoshizawa, T, Tokumoto, Y, Suzuki, N, Takeno, S, Takeno, K.J, Yamashita, T, Tanaka, S, Kaneko, Y, Fujiyama, K, Matsumura, H, Nakazawa, Y. | | 登録日 | 2020-04-08 | | 公開日 | 2021-02-17 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structure-function studies of ultrahigh molecular weight isoprenes provide key insights into their biosynthesis.
Commun Biol, 4, 2021
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6N7Y
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2H8O
 | | The 1.6A crystal structure of the geranyltransferase from Agrobacterium tumefaciens | | 分子名称: | Geranyltranstransferase | | 著者 | Zhang, R, Xu, X, Gu, J, Savchenko, A, Edwards, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2006-06-07 | | 公開日 | 2006-07-04 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | The 1.6A crystal structure of the geranyltransferase from Agrobacterium tumefaciens
To be Published
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