PDB: 129 件ウェブページステータス検索Chemie searchBIRD

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6L8O	Crystal structure of the K. lactis Rad5 (Hg-derivative) 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DNA repair protein RAD5, MERCURY (II) ION 著者 Shen, M, Xiang, S. 登録日 2019-11-06 公開日 2020-11-11 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Structural basis for the multi-activity factor Rad5 in replication stress tolerance. Nat Commun, 12, 2021
6L8N	Crystal structure of the K. lactis Rad5 分子名称: DNA repair protein RAD5, ZINC ION 著者 Shen, M, Xiang, S. 登録日 2019-11-06 公開日 2020-11-11 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Structural basis for the multi-activity factor Rad5 in replication stress tolerance. Nat Commun, 12, 2021
4KBL	Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism 分子名称: E3 ubiquitin-protein ligase ARIH1, ZINC ION 著者 Duda, D.M, Olszewski, J.L, Schulman, B.A. 登録日 2013-04-23 公開日 2013-05-29 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism. Structure, 21, 2013
8A58	X-ray structure of TRIM21 RING E3 ligase in complex with E2 enzyme Ube2W 分子名称: E3 ubiquitin-protein ligase TRIM21, Ubiquitin-conjugating enzyme E2 W, ZINC ION 著者 James, L.C, Kiss, L. 登録日 2022-06-14 公開日 2023-04-26 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Trim-Away ubiquitinates and degrades lysine-less and N-terminally acetylated substrates. Nat Commun, 14, 2023
8AMR	Coiled-coil domain of human TRIM3 分子名称: 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, GLYCEROL, Tripartite motif-containing protein 3 著者 Perez-Borrajero, C, Murciano, B, Hennig, J. 登録日 2022-08-04 公開日 2023-11-15 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.8 Å) 主引用文献 Structural and biophysical studies of TRIM2 and TRIM3 To Be Published
5O76	Structure of phosphoY371 c-CBL in complex with ZAP70-peptide and UbV.pCBL ubiquitin variant 分子名称: CALCIUM ION, E3 ubiquitin-protein ligase CBL, Tyrosine protein kinase ZAP70 peptide, ... 著者 Gabrielsen, M, Buetow, L, Huang, D.T. 登録日 2017-06-08 公開日 2017-11-01 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.473 Å) 主引用文献 A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants. Mol. Cell, 68, 2017
2Y1N	Structure of c-Cbl-ZAP-70 peptide complex 分子名称: CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE, TYROSINE-PROTEIN KINASE ZAP-70 ZAP-70,70 KDA ZETA-ASSOCIATED PROTEIN, ... 著者 Dou, H, Sibbet, G.J, Huang, D.T. 登録日 2010-12-08 公開日 2012-01-18 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.999 Å) 主引用文献 Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl. Nat.Struct.Mol.Biol., 19, 2012
8IEG	Bre1(mRBD-RING)/Rad6-Ub/nucleosome complex 分子名称: DNA (147-MER), E3 ubiquitin-protein ligase BRE1, Histone H2A type 1-B/E, ... 著者 Ai, H, Deng, Z, Pan, M, Liu, L. 登録日 2023-02-15 公開日 2023-09-06 最終更新日 2023-09-20 実験手法 ELECTRON MICROSCOPY (3.44 Å) 主引用文献 Mechanistic insights into nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A. Mol.Cell, 83, 2023
2Y1M	Structure of native c-Cbl 分子名称: CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE, ZINC ION 著者 Dou, H, Sibbet, G.J, Huang, D.T. 登録日 2010-12-08 公開日 2012-01-18 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.67 Å) 主引用文献 Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl. Nat.Struct.Mol.Biol., 19, 2012
4KC9	Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism 分子名称: E3 ubiquitin-protein ligase ARIH1, ZINC ION 著者 Duda, D.M, Olszewski, J.L, Schulman, B.A. 登録日 2013-04-24 公開日 2013-05-29 最終更新日 2013-07-03 実験手法 X-RAY DIFFRACTION (3.603 Å) 主引用文献 Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism. Structure, 21, 2013
5OLM	TRIM21 分子名称: E3 ubiquitin-protein ligase TRIM21, ZINC ION 著者 James, L.C. 登録日 2017-07-28 公開日 2018-04-25 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21. Elife, 7, 2018
6XNX	Structure of RAG1 (R848M/E649V)-RAG2-DNA Strand Transfer Complex (Dynamic-Form) 分子名称: 12RSS integration strand DNA (55-MER), 12RSS signal top strand DNA (34-MER), 23RSS integration strand DNA (66-MER), ... 著者 Zhang, Y, Corbett, E, Wu, S, Schatz, D.G. 登録日 2020-07-05 公開日 2020-08-26 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Structural basis for the activation and suppression of transposition during evolution of the RAG recombinase. Embo J., 39, 2020
6XNZ	Structure of RAG1 (R848M/E649V)-RAG2-DNA Target Capture Complex 分子名称: 12RSS integration strand (34-mer), 12RSS non-integration strand (34-mer), 23RSS integration strand (45-mer), ... 著者 Zhang, Y, Corbett, E, Wu, S, Schatz, D.G. 登録日 2020-07-05 公開日 2020-08-26 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structural basis for the activation and suppression of transposition during evolution of the RAG recombinase. Embo J., 39, 2020
6XNY	Structure of RAG1 (R848M/E649V)-RAG2-DNA Strand Transfer Complex (Paired-Form) 分子名称: 12RSS integration strand (55-mer), 12RSS signal DNA top strand (34-mer), 23RSS integration strand (66-mer), ... 著者 Zhang, Y, Corbett, E, Wu, S, Schatz, D.G. 登録日 2020-07-05 公開日 2020-08-26 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural basis for the activation and suppression of transposition during evolution of the RAG recombinase. Embo J., 39, 2020
6S53	Crystal structure of TRIM21 RING domain in complex with an isopeptide-linked Ube2N~ubiquitin conjugate 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, E3 ubiquitin-protein ligase TRIM21, Polyubiquitin-C, ... 著者 Kiss, L, Boland, A, Neuhaus, D, James, L.C. 登録日 2019-06-30 公開日 2019-09-11 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 A tri-ionic anchor mechanism drives Ube2N-specific recruitment and K63-chain ubiquitination in TRIM ligases. Nat Commun, 10, 2019
6TAY	Mouse RNF213 mutant R4753K modeling the Moyamoya-disease-related Human variant R4810K 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RNF213,E3 ubiquitin-protein ligase RNF213,E3 ubiquitin-protein ligase RNF213, ... 著者 Ahel, J, Meinhart, A, Haselbach, D, Clausen, T. 登録日 2019-10-31 公開日 2020-07-01 最終更新日 2021-01-13 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism. Elife, 9, 2020
6TAX	Mouse RNF213 wild type protein 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, RNF213,E3 ubiquitin-protein ligase RNF213,E3 ubiquitin-protein ligase RNF213, ... 著者 Ahel, J, Meinhart, A, Haselbach, D, Clausen, T. 登録日 2019-10-31 公開日 2020-07-01 最終更新日 2021-01-13 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism. Elife, 9, 2020
3JBY	Cryo-electron microscopy structure of RAG Paired Complex (C2 symmetry) 分子名称: '-D(P*GP*AP*TP*CP*TP*GP*GP*CP*CP*TP*GP*TP*CP*TP*TP*A)-3', 5'-D(P*CP*AP*CP*AP*GP*TP*GP*CP*TP*AP*CP*AP*GP*AP*C)-3', CALCIUM ION, ... 著者 Ru, H, Chambers, M.G, Fu, T.-M, Tong, A.B, Liao, M, Wu, H. 登録日 2015-10-22 公開日 2015-12-09 最終更新日 2024-02-21 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures. Cell(Cambridge,Mass.), 163, 2015
6OEO	Cryo-EM structure of mouse RAG1/2 NFC complex (DNA1) 分子名称: CALCIUM ION, DNA (46-MER), DNA (57-MER), ... 著者 Chen, X, Cui, Y, Zhou, Z.H, Yang, W, Gellert, M. 登録日 2019-03-27 公開日 2020-01-29 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.69 Å) 主引用文献 Cutting antiparallel DNA strands in a single active site. Nat.Struct.Mol.Biol., 27, 2020
6OEQ	Cryo-EM structure of mouse RAG1/2 12RSS-PRC/23RSS-NFC complex (DNA1) 分子名称: CALCIUM ION, DNA (46-MER), DNA (57-MER), ... 著者 Chen, X, Cui, Y, Zhou, Z.H, Yang, W, Gellert, M. 登録日 2019-03-27 公開日 2020-01-29 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Cutting antiparallel DNA strands in a single active site. Nat.Struct.Mol.Biol., 27, 2020
6OER	Cryo-EM structure of mouse RAG1/2 NFC complex (DNA2) 分子名称: CALCIUM ION, DNA (46-MER), DNA (57-MER), ... 著者 Chen, X, Cui, Y, Zhou, Z.H, Yang, W, Gellert, M. 登録日 2019-03-27 公開日 2020-01-29 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.29 Å) 主引用文献 Cutting antiparallel DNA strands in a single active site. Nat.Struct.Mol.Biol., 27, 2020
3JBX	Cryo-electron microscopy structure of RAG Signal End Complex (C2 symmetry) 分子名称: 5'-D(*CP*AP*CP*AP*GP*TP*GP*CP*TP*AP*CP*AP*GP*AP*C)-3', 5'-D(*GP*CP*GP*AP*TP*GP*GP*TP*TP*AP*AP*CP*CP*A)-3', 5'-D(P*GP*TP*CP*TP*GP*TP*AP*GP*CP*AP*CP*TP*GP*TP*G)-3', ... 著者 Ru, H, Chambers, M.G, Fu, T.-M, Tong, A.B, Liao, M, Wu, H. 登録日 2015-10-22 公開日 2015-12-09 最終更新日 2024-02-21 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures. Cell(Cambridge,Mass.), 163, 2015
3JBW	Cryo-electron microscopy structure of RAG Paired Complex (with NBD, no symmetry) 分子名称: 12-RSS signal end forward strand, 5'-D(P*GP*AP*TP*CP*TP*GP*GP*CP*CP*TP*GP*TP*CP*TP*TP*A)-3', Nicked 12-RSS intermediate reverse strand, ... 著者 Ru, H, Chambers, M.G, Fu, T.-M, Tong, A.B, Liao, M, Wu, H. 登録日 2015-10-21 公開日 2015-12-09 最終更新日 2024-02-21 実験手法 ELECTRON MICROSCOPY (4.6 Å) 主引用文献 Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures. Cell(Cambridge,Mass.), 163, 2015
8GCY	Co-crystal structure of CBL-B in complex with N-Aryl isoindolin-1-one inhibitor 分子名称: 1,2-ETHANEDIOL, 2-{3-[(1s,3R)-3-methyl-1-(4-methyl-4H-1,2,4-triazol-3-yl)cyclobutyl]phenyl}-6-{[(3S)-3-methylpiperidin-1-yl]methyl}-4-(trifluoromethyl)-2,3-dihydro-1H-isoindol-1-one, E3 ubiquitin-protein ligase CBL-B, ... 著者 Kimani, S, Zeng, H, Dong, A, Li, Y, Santhakumar, V, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) 登録日 2023-03-03 公開日 2023-03-22 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 The co-crystal structure of Cbl-b and a small-molecule inhibitor reveals the mechanism of Cbl-b inhibition. Commun Biol, 6, 2023
5HKX	Crystal Structure of c-Cbl TKBD-RING domains (Y371E mutant) Refined to 1.85 A Resolution 分子名称: 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase CBL, SODIUM ION, ... 著者 Lovell, S, Battaile, K.P, Mehzabeen, N, Zhang, N, Cooper, A, Gao, P, Perez, R.P. 登録日 2016-01-14 公開日 2017-01-18 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Crystal Structure of c-Cbl TKBD-RING domains (Y371E mutant) Refined to 1.85 A Resolution To be published

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