9FQH
E3 ligase Cbl-b in complex with a triazolone core inhibitor (compound 1)
This is a non-PDB format compatible entry.
Summary for 9FQH
Entry DOI | 10.2210/pdb9fqh/pdb |
Descriptor | E3 ubiquitin-protein ligase CBL-B, 8-[3-[3-methyl-1-(4-methyl-1,2,4-triazol-3-yl)cyclobutyl]phenyl]-3-[[(3~{S})-3-methylpiperidin-1-yl]methyl]-5-(trifluoromethyl)-1$l^{4},7,8-triazabicyclo[4.3.0]nona-1(6),2,4-trien-9-one, ZINC ION, ... (5 entities in total) |
Functional Keywords | ligase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 46502.92 |
Authors | |
Primary citation | Quinn, T.R. Accelerated Discovery of a Carbamate Scaffold Cbl-b Inhibitor using Generative Models and Structure-Based Drug Design To be published, |
Experimental method | X-RAY DIFFRACTION (1.786 Å) |
Structure validation
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