5V30
| Crystal structure of the sensor domain of the transcriptional regulator HcpR from Porphyromonas Gingivalis | 分子名称: | GLYCEROL, SULFATE ION, Transcriptional regulator | 著者 | Musayev, F.N, Belvin, B.R, Escalante, C.R, Turner, J, Lewis, J.P. | 登録日 | 2017-03-06 | 公開日 | 2018-06-13 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | Nitrosative stress sensing in Porphyromonas gingivalis: structure of and heme binding by the transcriptional regulator HcpR. Acta Crystallogr D Struct Biol, 75, 2019
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1Q5O
| HCN2J 443-645 in the presence of cAMP, selenomethionine derivative | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | 著者 | Zagotta, W.N, Olivier, N.B, Black, K.D, Young, E.C, Olson, R, Gouaux, J.E. | 登録日 | 2003-08-08 | 公開日 | 2003-09-09 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | STRUCTURAL BASIS FOR MODULATION AND AGONIST SPECIFICITY OF HCN PACEMAKER CHANNELS Nature, 425, 2003
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1Q43
| HCN2I 443-640 in the presence of cAMP, selenomethionine derivative | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | 著者 | Zagotta, W.N, Olivier, N.B, Black, K.D, Young, E.C, Olson, R, Gouaux, J.E. | 登録日 | 2003-08-01 | 公開日 | 2003-09-09 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis for modulation and agonist specificity of HCN pacemaker channels Nature, 425, 2003
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1Q3E
| HCN2J 443-645 in the presence of cGMP | 分子名称: | CYCLIC GUANOSINE MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | 著者 | Zagotta, W.N, Olivier, N.B, Black, K.D, Young, E.C, Olson, R, Gouaux, J.E. | 登録日 | 2003-07-29 | 公開日 | 2003-09-09 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural basis for modulation and agonist specificity of HCN pacemaker channels Nature, 425, 2003
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1RL3
| Crystal structure of cAMP-free R1a subunit of PKA | 分子名称: | CYCLIC GUANOSINE MONOPHOSPHATE, GLYCEROL, cAMP-dependent protein kinase type I-alpha regulatory chain | 著者 | Wu, J, Brown, S, Xuong, N.-H, Taylor, S.S. | 登録日 | 2003-11-24 | 公開日 | 2004-07-06 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | RIalpha subunit of PKA: a cAMP-free structure reveals a hydrophobic capping mechanism for docking cAMP into site B. Structure, 12, 2004
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2K0G
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1RGS
| REGULATORY SUBUNIT OF CAMP DEPENDENT PROTEIN KINASE | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CAMP DEPENDENT PROTEIN KINASE | 著者 | Su, Y, Dostmann, W.R.G, Herberg, F.W, Durick, K, Xuong, N.-H, Ten Eyck, L, Taylor, S.S, Varughese, K.I. | 登録日 | 1995-06-21 | 公開日 | 1996-12-07 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains. Science, 269, 1995
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2KXL
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1NE6
| Crystal structure of Sp-cAMP binding R1a subunit of cAMP-dependent protein kinase | 分子名称: | 6-(6-AMINO-PURIN-9-YL)-2-THIOXO-TETRAHYDRO-2-FURO[3,2-D][1,3,2]DIOXAPHOSPHININE-2,7-DIOL, cAMP-dependent protein kinase type I-alpha regulatory chain | 著者 | Wu, J, Jones, J.M, Xuong, N.H, Taylor, S.S. | 登録日 | 2002-12-10 | 公開日 | 2004-01-13 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal Structures of RIalpha Subunit of Cyclic Adenosine 5'-Monophosphate (cAMP)-Dependent Protein Kinase Complexed with (R(p))-Adenosine 3',5'-Cyclic Monophosphothioate and (S(p))-Adenosine 3',5'-Cyclic Monophosphothioate, the Phosphothioate Analogues of cAMP. Biochemistry, 43, 2004
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1NE4
| Crystal Structure of Rp-cAMP Binding R1a Subunit of cAMP-dependent Protein Kinase | 分子名称: | 6-(6-AMINO-PURIN-9-YL)-2-THIOXO-TETRAHYDRO-2-FURO[3,2-D][1,3,2]DIOXAPHOSPHININE-2,7-DIOL, cAMP-dependent protein kinase type I-alpha regulatory chain | 著者 | Wu, J, Jones, J.M, Xuong, N.H, Taylor, S.S. | 登録日 | 2002-12-10 | 公開日 | 2004-01-13 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal Structures of RIalpha Subunit of Cyclic Adenosine 5'-Monophosphate (cAMP)-Dependent Protein Kinase Complexed with (R(p))-Adenosine 3',5'-Cyclic Monophosphothioate and (S(p))-Adenosine 3',5'-Cyclic Monophosphothioate, the Phosphothioate Analogues of cAMP. Biochemistry, 43, 2004
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2MHF
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2MNG
| Apo Structure of human HCN4 CNBD solved by NMR | 分子名称: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | 著者 | Akimoto, M, Zhang, Z, Boulton, S, Selvaratnam, R, VanSchouwen, B, Gloyd, M, Accili, E.A, Lange, O.F, Melacini, G. | 登録日 | 2014-04-03 | 公開日 | 2014-06-04 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | A mechanism for the auto-inhibition of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel opening and its relief by cAMP. J.Biol.Chem., 289, 2014
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2MPF
| Solution structure human HCN2 CNBD in the cAMP-unbound state | 分子名称: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | 著者 | Saponaro, A, Pauleta, S.R, Cantini, F, Matzapetakis, M, Hammann, C, Banci, L, Thiel, G, Santoro, B, Moroni, A. | 登録日 | 2014-05-16 | 公開日 | 2014-09-03 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function. Proc.Natl.Acad.Sci.USA, 111, 2014
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6BQ8
| Joint X-ray/neutron structure of PKG II CNB-B domain in complex with 8-pCPT-cGMP | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(~2~H_2_)amino-8-[(4-chlorophenyl)sulfanyl]-9-[(2S,4aR,6R,7R,7aS)-2-hydroxy-7-(~2~H)hydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl](~2~H)-1,9-dihydro-6H-purin-6-one, STRONTIUM ION, ... | 著者 | Kim, C, Kovalevsky, A, Gerlits, O. | 登録日 | 2017-11-27 | 公開日 | 2018-03-21 | 最終更新日 | 2024-04-03 | 実験手法 | NEUTRON DIFFRACTION (2 Å), X-RAY DIFFRACTION | 主引用文献 | Neutron Crystallography Detects Differences in Protein Dynamics: Structure of the PKG II Cyclic Nucleotide Binding Domain in Complex with an Activator. Biochemistry, 57, 2018
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6CPB
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5E16
| Co-crystal structure of the N-termial cGMP binding domain of Plasmodium falciparum PKG with cGMP | 分子名称: | CGMP-dependent protein kinase, CYCLIC GUANOSINE MONOPHOSPHATE | 著者 | El Bakkouri, M, Walker, J.R, Loppnau, P, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hui, R, Structural Genomics Consortium (SGC) | 登録日 | 2015-09-29 | 公開日 | 2015-11-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation. Proc.Natl.Acad.Sci.USA, 116, 2019
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5H5O
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6FTF
| Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma cruzi at 1.09 A resolution | 分子名称: | 1,2-ETHANEDIOL, 7-cyano-7-deazainosine, Protein kinase A regulatory subunit, ... | 著者 | Volpato Santos, Y, Lorentzen, E, Basquin, J, Boshart, M. | 登録日 | 2018-02-21 | 公開日 | 2019-04-03 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.09151936 Å) | 主引用文献 | Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma. Nat Commun, 10, 2019
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4MUV
| M. loti cyclic-nucleotide binding domain mutant displaying inverted ligand selectivity, cyclic-GMP bound | 分子名称: | CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated potassium channel mll3241, SODIUM ION | 著者 | Fonseca, F, Pessoa, J, Morais-Cabral, J.H. | 登録日 | 2013-09-23 | 公開日 | 2014-06-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Determinants of ligand selectivity in a cyclic nucleotide-regulated potassium channel. J.Gen.Physiol., 144, 2014
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6FLO
| Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma brucei at 2.1 Angstrom resolution | 分子名称: | GLYCEROL, INOSINE, Protein kinase A regulatory subunit | 著者 | Volpato Santos, Y, Lorentzen, E, Basquin, J, Boshart, M. | 登録日 | 2018-01-26 | 公開日 | 2019-08-14 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.13868666 Å) | 主引用文献 | Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens. Elife, 12, 2024
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4NVP
| Structure of the cyclic nucleotide-binding domain of HCN4 channel complexed with 7-CH-cAMP | 分子名称: | (2S,4aR,6R,7R,7aS)-6-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | 著者 | Alfieri, A, Moroni, A. | 登録日 | 2013-12-05 | 公開日 | 2014-03-19 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Cyclic Nucleotide Mapping of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels. Acs Chem.Biol., 9, 2014
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6H4G
| Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma brucei: E311A, T318R, V319A mutant bound to cAMP in the A site | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, INOSINE, Protein kinase A regulatory subunit | 著者 | Volpato Santos, Y, Lorentzen, E, Basquin, J, Boshart, M. | 登録日 | 2018-07-21 | 公開日 | 2019-08-14 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.143517 Å) | 主引用文献 | Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens. Elife, 12, 2024
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6HQ3
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4D7T
| Structure of the SthK Carboxy-Terminal Region in complex with cAMP | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, STHK_CNBD_CAMP | 著者 | Kesters, D, Brams, M, Nys, M, Wijckmans, E, Spurny, R, Voets, T, Tytgat, J, Ulens, C. | 登録日 | 2014-11-27 | 公開日 | 2015-02-11 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.582 Å) | 主引用文献 | Structure of the SthK Carboxy-Terminal Region Reveals a Gating Mechanism for Cyclic Nucleotide-Modulated Ion Channels. Plos One, 10, 2015
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6HQ2
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