9SQ9
 
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9OJD
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9YX5
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9OJW
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7KO0
 | | Crystal structure of the second bromodomain (BD2) of human BRD4 bound to SG3-179 | | 分子名称: | 1,2-ETHANEDIOL, 4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{N}-(1-methylpiperidin-4-yl)benzamide, Bromodomain-containing protein 4 | | 著者 | Karim, M.R, Zhu, J.Y, Schonbrunn, E. | | 登録日 | 2020-11-06 | | 公開日 | 2021-10-20 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors.
J.Med.Chem., 64, 2021
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6PO2
 | | In situ structure of BTV RNA-dependent RNA polymerase in BTV core | | 分子名称: | Inner core structural protein VP3, RNA-directed RNA polymerase | | 著者 | He, Y, Shivakoti, S, Ding, K, Cui, Y, Roy, P, Zhou, Z.H. | | 登録日 | 2019-07-03 | | 公開日 | 2019-08-07 | | 最終更新日 | 2025-05-21 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | In situ structures of RNA-dependent RNA polymerase inside bluetongue virus before and after uncoating.
Proc.Natl.Acad.Sci.USA, 116, 2019
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5VZ4
 | | Receptor-growth factor crystal structure at 2.20 Angstrom resolution | | 分子名称: | 1,2-ETHANEDIOL, BROMIDE ION, GDNF family receptor alpha-like, ... | | 著者 | Lakshminarasimhan, D, White, A, Suto, R.K. | | 登録日 | 2017-05-26 | | 公開日 | 2017-09-27 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.
Nature, 550, 2017
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9OP5
 | | Herpes simplex virus type 1 (HSV-1) B-capsid pUL6 portal protein, dodecameric complex | | 分子名称: | Capsid portal protein, Capsid scaffolding protein | | 著者 | Crofut, E.H, Kashyap, S, Stevens, A, Jih, J, Liu, Y.-T, Zhou, Z.H. | | 登録日 | 2025-05-16 | | 公開日 | 2025-05-28 | | 最終更新日 | 2025-07-30 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structure of a new capsid form and comparison with A-, B-, and C-capsids clarify herpesvirus assembly.
J.Virol., 99, 2025
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9OPC
 | | Herpes simplex virus type 1 (HSV-1) C-capsid pUL6 portal protein, dodecameric complex | | 分子名称: | Capsid portal protein | | 著者 | Crofut, E.H, Kashyap, S, Stevens, A, Jih, J, Liu, Y.-T, Zhou, Z.H. | | 登録日 | 2025-05-18 | | 公開日 | 2025-05-28 | | 最終更新日 | 2025-08-06 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Structure of a new capsid form and comparison with A-, B-, and C-capsids clarify herpesvirus assembly.
J.Virol., 99, 2025
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5ITD
 | | Crystal structure of PI3K alpha with PI3K delta inhibitor | | 分子名称: | 5-{4-[3-(4-acetylpiperazine-1-carbonyl)phenyl]quinazolin-6-yl}-2-methoxypyridine-3-carbonitrile, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | | 著者 | Knapp, M.S, Elling, R.A. | | 登録日 | 2016-03-16 | | 公開日 | 2016-09-07 | | 最終更新日 | 2025-04-09 | | 実験手法 | X-RAY DIFFRACTION (3.02 Å) | | 主引用文献 | Discovery and Pharmacological Characterization of Novel Quinazoline-Based PI3K Delta-Selective Inhibitors.
Acs Med.Chem.Lett., 7, 2016
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9OP8
 | | Herpes simplex virus type 1 (HSV-1) D-capsid pUL6 portal protein, dodecameric complex | | 分子名称: | Capsid portal protein | | 著者 | Crofut, E.H, Kashyap, S, Stevens, A, Jih, J, Liu, Y.-T, Zhou, Z.H. | | 登録日 | 2025-05-17 | | 公開日 | 2025-05-28 | | 最終更新日 | 2025-07-30 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structure of a new capsid form and comparison with A-, B-, and C-capsids clarify herpesvirus assembly.
J.Virol., 99, 2025
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4XJM
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9FD8
 | | Re-engineered peroxygenase variant of 2-deoxy-D-ribose-5-phosphate aldolase, Schiff-base complex with 4-chloro-cinnamaldehyde | | 分子名称: | (2E)-3-(4-chlorophenyl)prop-2-enal, Deoxyribose-phosphate aldolase, GLYCEROL | | 著者 | Thunnissen, A.M.W.H, Zhou, H, Frietema, H.O.T, Poelarends, G.J. | | 登録日 | 2024-05-16 | | 公開日 | 2025-03-12 | | 最終更新日 | 2025-05-21 | | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | | 主引用文献 | Engineering 2-Deoxy-D-ribose-5-phosphate Aldolase for anti- and syn-Selective Epoxidations of alpha , beta-Unsaturated Aldehydes.
Angew.Chem.Int.Ed.Engl., 64, 2025
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9QCU
 | | Crystal structure of Rhizobium etli L-asparaginase ReAV S48A mutant | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Pokrywka, K, Grzechowiak, M, Loch, J.I, Ruszkowski, M, Gilski, M, Jaskolski, M. | | 登録日 | 2025-03-05 | | 公開日 | 2025-07-16 | | 最終更新日 | 2025-08-06 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Probing the Active Site of Class 3 L-Asparaginase by Mutagenesis: Mutations of the Ser-Lys Tandems of ReAV.
Biomolecules, 15, 2025
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7PLF
 | | Human Carbonic Anhydrase I in complex with clorsulon | | 分子名称: | 4-azanyl-6-[1,2,2-tris(chloranyl)ethenyl]benzene-1,3-disulfonamide, Carbonic anhydrase 1, ZINC ION | | 著者 | Angeli, A, Ferraroni, M. | | 登録日 | 2021-08-31 | | 公開日 | 2022-09-07 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.461 Å) | | 主引用文献 | Inhibition of Schistosoma mansoni carbonic anhydrase by the antiparasitic drug clorsulon: X-ray crystallographic and in vitro studies.
Acta Crystallogr D Struct Biol, 78, 2022
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8TDU
 | | STX-478, a Mutant-Selective, Allosteric Inhibitor bound to PI3Kalpha | | 分子名称: | N-(2-aminopyrimidin-5-yl)-N'-[(1R)-1-(5,7-difluoro-3-methyl-1-benzofuran-2-yl)-2,2,2-trifluoroethyl]urea, N~2~-{(4S,11aP)-2-[(4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}-L-alaninamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, ... | | 著者 | Hilbert, B.J, Brooijmans, N, Buckbinder, L, St.Jean Jr, D.J. | | 登録日 | 2023-07-05 | | 公開日 | 2023-09-06 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.11 Å) | | 主引用文献 | STX-478, a Mutant-Selective, Allosteric PI3K alpha Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3K alpha-Mutant Xenografts.
Cancer Discov, 13, 2023
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6XJU
 | | Crystal Structure of KPT-8602 bound to CRM1 (E582K, 537-DLTVK-541 to GLCEQ) | | 分子名称: | (2R)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(pyrimidin-5-yl)propanamide, Exportin-1, GTP-binding nuclear protein Ran, ... | | 著者 | Baumhardt, J.M, Chook, Y.M. | | 登録日 | 2020-06-24 | | 公開日 | 2021-01-27 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.193 Å) | | 主引用文献 | Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia.
J Hematol Oncol, 14, 2021
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8VH8
 | | Crystal structure of heparosan synthase 2 from Pasteurella multocida at 2.85 A | | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Pedersen, L.C, Liu, J, Stancanelli, E, krahn, J.M. | | 登録日 | 2023-12-31 | | 公開日 | 2024-09-04 | | 最終更新日 | 2025-03-12 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Structural and Functional Analysis of Heparosan Synthase 2 from Pasteurella multocida (PmHS2) to Improve the Synthesis of Heparin.
Acs Catalysis, 14, 2024
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9FD9
 | | Re-engineered peroxygenase variant of 2-deoxy-D-ribose-5-phosphate aldolase, Schiff-base complex with 4-nitro-cinnamaldehyde | | 分子名称: | 4-nitro-cinnamaldehyde, Deoxyribose-phosphate aldolase, GLYCEROL | | 著者 | Thunnissen, A.M.W.H, Zhou, H, Frietema, H.O.T, Poelarends, G.J. | | 登録日 | 2024-05-16 | | 公開日 | 2025-03-12 | | 最終更新日 | 2025-05-21 | | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | | 主引用文献 | Engineering 2-Deoxy-D-ribose-5-phosphate Aldolase for anti- and syn-Selective Epoxidations of alpha , beta-Unsaturated Aldehydes.
Angew.Chem.Int.Ed.Engl., 64, 2025
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6PBQ
 | | Structure of ClpC1-NTD | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ATP-dependent Clp protease ATP-binding subunit ClpC1, PHOSPHATE ION | | 著者 | Abad-Zapatero, C, Wolf, N.M. | | 登録日 | 2019-06-14 | | 公開日 | 2020-05-13 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structure of the N-terminal domain of ClpC1 in complex with the antituberculosis natural product ecumicin reveals unique binding interactions.
Acta Crystallogr D Struct Biol, 76, 2020
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9UKU
 | | CryoEM structure of the T.thermophilus transcription initiation complex bound to Gp4A-C, -1 dC in the template DNA strand | | 分子名称: | CHAPSO, CYTIDINE-5'-MONOPHOSPHATE, DNA-directed RNA polymerase subunit alpha, ... | | 著者 | Duan, W, Kaushik, A, Serganov, A. | | 登録日 | 2025-04-18 | | 公開日 | 2025-10-22 | | 最終更新日 | 2025-10-29 | | 実験手法 | ELECTRON MICROSCOPY (2.73 Å) | | 主引用文献 | Molecular basis for noncanonical transcription initiation from Np 4 A alarmones.
Nat.Chem.Biol., 2025
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5I94
 | | Crystal structure of human glutaminase C in complex with the inhibitor UPGL-00019 | | 分子名称: | 2-phenyl-N-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}oxy)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide, Glutaminase kidney isoform, mitochondrial | | 著者 | Huang, Q, Cerione, R. | | 登録日 | 2016-02-19 | | 公開日 | 2016-05-11 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.983 Å) | | 主引用文献 | Design and evaluation of novel glutaminase inhibitors.
Bioorg.Med.Chem., 24, 2016
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9OLZ
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9OP4
 | | Herpes simplex virus type 1 (HSV-1) A-capsid pUL6 portal protein, dodecameric complex | | 分子名称: | Capsid portal protein, Capsid scaffolding protein | | 著者 | Crofut, E.H, Kashyap, S, Stevens, A, Jih, J, Liu, Y.-T, Zhou, Z.H. | | 登録日 | 2025-05-16 | | 公開日 | 2025-06-11 | | 最終更新日 | 2025-07-30 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structure of a new capsid form and comparison with A-, B-, and C-capsids clarify herpesvirus assembly.
J.Virol., 99, 2025
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7PRI
 | | Carbonic Anhydrase from Schistosoma Mansoni in complex with clorsulon | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-azanyl-6-[1,2,2-tris(chloranyl)ethenyl]benzene-1,3-disulfonamide, Carbonic anhydrase, ... | | 著者 | Angeli, A, Ferraroni, M. | | 登録日 | 2021-09-21 | | 公開日 | 2022-10-05 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.679 Å) | | 主引用文献 | Inhibition of Schistosoma mansoni carbonic anhydrase by the antiparasitic drug clorsulon: X-ray crystallographic and in vitro studies.
Acta Crystallogr D Struct Biol, 78, 2022
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