PDB: 2435 件ウェブページステータス検索Chemie searchBIRD

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6BX3	Structure of histone H3k4 methyltransferase 分子名称: COMPASS component BRE2, COMPASS component SDC1, COMPASS component SPP1, ... 著者 Skiniotis, G, Qu, Q.H. 登録日 2017-12-16 公開日 2018-09-05 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex. Cell, 174, 2018
6BLY	Cryo-EM structure of human CPSF-160-WDR33 complex at 3.36A resolution 分子名称: Cleavage and polyadenylation specificity factor subunit 1, pre-mRNA 3' end processing protein WDR33 著者 Sun, Y, Zhang, Y, Hamilton, K, Walz, T, Tong, L. 登録日 2017-11-12 公開日 2017-11-22 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.36 Å) 主引用文献 Molecular basis for the recognition of the human AAUAAA polyadenylation signal. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6CRK	Heterotrimeric G-protein in complex with an antibody fragment 分子名称: CITRATE ANION, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Maeda, S, Dawson, R, Kobilka, B. 登録日 2018-03-19 公開日 2018-10-24 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Development of an antibody fragment that stabilizes GPCR/G-protein complexes. Nat Commun, 9, 2018
6CKC	Structure of PRMT5:MEP50 in complex with LLY-283, a potent and selective inhibitor of PRMT5, with antitumor activity 分子名称: 7-[(5R)-5-C-phenyl-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Methylosome protein 50, Protein arginine N-methyltransferase 5 著者 Antonysamy, S. 登録日 2018-02-27 公開日 2018-05-16 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity. ACS Med Chem Lett, 9, 2018
6C23	Cryo-EM structure of PRC2 bound to cofactors AEBP2 and JARID2 in the Compact Active State 分子名称: Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH2, JARID2-substrate, ... 著者 Kasinath, V, Faini, M, Poepsel, S, Reif, D, Feng, A, Stjepanovic, G, Aebersold, R, Nogales, E. 登録日 2018-01-05 公開日 2018-01-24 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structures of human PRC2 with its cofactors AEBP2 and JARID2. Science, 359, 2018
6CHG	Crystal structure of the yeast COMPASS catalytic module 分子名称: H3, Histone-lysine N-methyltransferase, H3 lysine-4 specific, ... 著者 Hsu, P.L, Li, H, Zheng, N. 登録日 2018-02-22 公開日 2018-08-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.985 Å) 主引用文献 Crystal Structure of the COMPASS H3K4 Methyltransferase Catalytic Module. Cell, 174, 2018
6B3W	Structure of Hs/AcPRC2 in complex with 5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one 分子名称: 5,8-dichloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-2-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one, Enhancer of zeste 2 polycomb repressive complex 2 subunit,Enhancer of zeste 2 polycomb repressive complex 2 subunit, Polycomb protein EED, ... 著者 Gajiwala, K.S, Brooun, A, Liu, W, Deng, Y, Stewart, A.E. 登録日 2017-09-25 公開日 2017-12-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497). J. Med. Chem., 61, 2018
6C24	Cryo-EM structure of PRC2 bound to cofactors AEBP2 and JARID2 in the Extended Active State 分子名称: Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH2, JARID2-substrate, ... 著者 Kasinath, V, Faini, M, Poepsel, S, Reif, D, Feng, A, Stjepanovic, G, Aebersold, R, Nogales, E. 登録日 2018-01-06 公開日 2018-01-24 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structures of human PRC2 with its cofactors AEBP2 and JARID2. Science, 359, 2018
6BW3	Crystal structure of RBBP4 in complex with PRDM3 N-terminal peptide 分子名称: Histone-binding protein RBBP4, MDS1 and EVI1 complex locus protein MDS1, UNKNOWN ATOM OR ION 著者 Ivanochko, D, Halabelian, L, Hutchinson, A, Seitova, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC) 登録日 2017-12-14 公開日 2017-12-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex. Nucleic Acids Res., 47, 2019
6BW4	Crystal structure of RBBP4 in complex with PRDM16 N-terminal peptide 分子名称: Histone-binding protein RBBP4, PR domain zinc finger protein 16, UNKNOWN ATOM OR ION 著者 Ivanochko, D, Halabelian, L, Hutchinson, A, Seitova, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Structural Genomics Consortium (SGC) 登録日 2017-12-14 公開日 2017-12-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex. Nucleic Acids Res., 47, 2019
7S1Q	PRMT5/MEP50 crystal structure with MTA and a phthalazinone inhibitor bound (Compound 9) 分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein 50, Protein arginine N-methyltransferase 5, ... 著者 Gunn, R.J, Thomas, N.C, Lawson, J.D, Ivetac, A, Smith, C.R, Kulyk, S, Marx, M.A. 登録日 2021-09-02 公開日 2022-01-26 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.78 Å) 主引用文献 Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP -Deleted Cancers. J.Med.Chem., 65, 2022
7S1S	PRMT5/MEP50 crystal structure with MTA and MRTX-1719 bound 分子名称: (7-{(5M)-5-[3-chloro-6-cyano-5-(cyclopropyloxy)-2-fluorophenyl]-1-methyl-1H-pyrazol-4-yl}-4-oxo-3,4-dihydrophthalazin-1-yl)methanaminium, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein 50, ... 著者 Gunn, R.J, Thomas, N.C, Lawson, J.D, Ivetac, A, Kulyk, S, Smith, C.R, Marx, M.A. 登録日 2021-09-02 公開日 2022-01-26 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.62 Å) 主引用文献 Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP -Deleted Cancers. J.Med.Chem., 65, 2022
7SES	PRMT5/MEP50 with compound 29 bound 分子名称: (2P)-2-{4-[4-(aminomethyl)-1-oxo-1,2-dihydrophthalazin-6-yl]-1-methyl-1H-pyrazol-5-yl}naphthalene-1-carbonitrile, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein 50, ... 著者 Gunn, R.J, Thomas, N.C, Lawson, J.D, Ivetac, A, Smith, C.R, Kulyk, S, Marx, M.A. 登録日 2021-10-01 公開日 2022-01-26 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP -Deleted Cancers. J.Med.Chem., 65, 2022
7S1R	PRMT5/MEP50 crystal structure with MTA and a phthalazinone inhibitor bound (compound (M)-31) 分子名称: 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein 50, Protein arginine N-methyltransferase 5, ... 著者 Gunn, R.J, Thomas, N.C, Lawson, J.D, Ivetac, A, Kulyk, S, Smith, C.R, Marx, M.A. 登録日 2021-09-02 公開日 2022-01-26 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP -Deleted Cancers. J.Med.Chem., 65, 2022
7SER	PRMT5/MEP50 with compound 30 bound 分子名称: (2M)-2-{4-[4-(aminomethyl)-1-oxo-1,2-dihydrophthalazin-6-yl]-1-methyl-1H-pyrazol-5-yl}-1-benzothiophene-3-carbonitrile, 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein 50, ... 著者 Gunn, R.J, Thomas, N.C, Lawson, J.D, Ivetac, A, Smith, C.R, Kulyk, S, Marx, M.A. 登録日 2021-10-01 公開日 2022-01-26 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP -Deleted Cancers. J.Med.Chem., 65, 2022
7S0U	PRMT5/MEP50 crystal structure with MTA and phthalazinone fragment bound 分子名称: 1,2-ETHANEDIOL, 4-(aminomethyl)phthalazin-1(2H)-one, 5'-DEOXY-5'-METHYLTHIOADENOSINE, ... 著者 Gunn, R.J, Thomas, N.C, Lawson, J.D, Ivetac, A, Smith, C.R, Kulyk, S, Marx, M.A. 登録日 2021-08-31 公開日 2022-01-26 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP -Deleted Cancers. J.Med.Chem., 65, 2022
7S1P	PRMT5/MEP50 crystal structure with sinefungin bound 分子名称: Methylosome protein 50, Protein arginine N-methyltransferase 5, SINEFUNGIN 著者 Gunn, R.J, Thomas, N.C, Lawson, J.D, Ivetac, A, Kulyk, S, Smith, C.R, Marx, M.A. 登録日 2021-09-02 公開日 2022-03-16 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP -Deleted Cancers. J.Med.Chem., 65, 2022
7STY	Crystal structure of human CORO1C 分子名称: Coronin-1C 著者 Zeng, H, Dong, A, Hutchinson, A, Seitova, A, Loppnau, P, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) 登録日 2021-11-15 公開日 2021-12-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of human CORO1C To Be Published
6JPL	The X-ray structure of yeast tRNA methyltransferase Trm7-Trm734 in complex with S-adenosyl-L-methionine 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, S-ADENOSYLMETHIONINE, SULFATE ION, ... 著者 Hirata, A, Okada, K, Yoshii, K, Shiraisi, H, Saijo, S, Yonezawa, K, Shimizu, N, Hori, H. 登録日 2019-03-27 公開日 2019-10-02 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.32 Å) 主引用文献 Structure of tRNA methyltransferase complex of Trm7 and Trm734 reveals a novel binding interface for tRNA recognition. Nucleic Acids Res., 47, 2019
7T1Y	Structure of the Fbw7-Skp1-MycCdegron complex 分子名称: F-box/WD repeat-containing protein 7, Myc proto-oncogene protein C terminal degron, S-phase kinase-associated protein 1, ... 著者 Wang, B, Rusnac, D.V, Clurman, B.E, Zheng, N. 登録日 2021-12-02 公開日 2022-02-16 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor. Sci Adv, 8, 2022
7T1Z	Structure of the Fbw7-Skp1-MycNdegron complex 分子名称: F-box/WD repeat-containing protein 7, Myc proto-oncogene N terminal degron, S-phase kinase-associated protein 1, ... 著者 Wang, B, Rusnac, D.V, Clurman, B.E, Zheng, N. 登録日 2021-12-02 公開日 2022-02-16 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.77 Å) 主引用文献 Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor. Sci Adv, 8, 2022
6JLQ	Crystal structure of human USP46-WDR48-WDR20 complex 分子名称: GLYCEROL, PHOSPHATE ION, Ubiquitin carboxyl-terminal hydrolase 46, ... 著者 Zhu, H, Zhang, T, Ding, J. 登録日 2019-03-06 公開日 2019-07-10 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.101 Å) 主引用文献 Structural insights into the activation of USP46 by WDR48 and WDR20. Cell Discov, 5, 2019
6JP6	The X-ray structure of yeast tRNA methyltransferase complex of Trm7 and Trm734 essential for 2'-O-methylation at the first position of anticodon in specific tRNAs 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, SULFATE ION, tRNA (cytidine(34)/guanosine(34)-2'-O)-methyltransferase, ... 著者 Hirata, A, Okada, K, Yoshii, K, Shiraisi, H, Saijo, S, Yonezawa, K, Sihimzu, N, Hori, H. 登録日 2019-03-26 公開日 2019-10-02 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.699 Å) 主引用文献 Structure of tRNA methyltransferase complex of Trm7 and Trm734 reveals a novel binding interface for tRNA recognition. Nucleic Acids Res., 47, 2019
6HQA	Molecular structure of promoter-bound yeast TFIID 分子名称: Histone-fold, Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation, ... 著者 Kolesnikova, O, Ben-Shem, A, Luo, J, Ranish, J, Schultz, P, Papai, G. 登録日 2018-09-24 公開日 2018-11-21 最終更新日 2022-03-30 実験手法 ELECTRON MICROSCOPY (7.1 Å) 主引用文献 Molecular structure of promoter-bound yeast TFIID. Nat Commun, 9, 2018
6K1S	Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase (PRMT5) Inhibitors 分子名称: 1,2-ETHANEDIOL, 2-[[7-[(2~{R},3~{R},4~{S},5~{R})-5-[(~{R})-(4-chlorophenyl)-oxidanyl-methyl]-3,4-bis(oxidanyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidin-4-yl]amino]ethanal, DIMETHYL SULFOXIDE, ... 著者 Tong, S, Lin, H. 登録日 2019-05-12 公開日 2019-06-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Discovery of Potent and Selective Covalent Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors. Acs Med.Chem.Lett., 10, 2019

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