PDB: 2471 件ウェブページステータス検索Chemie searchBIRD

---

4JSN	structure of mTORdeltaN-mLST8 complex 分子名称: Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 著者 Pavletich, N.P. 登録日 2013-03-22 公開日 2013-05-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 mTOR kinase structure, mechanism and regulation. Nature, 497, 2013
4JT6	structure of mTORDeltaN-mLST8-PI-103 complex 分子名称: 3-(4-MORPHOLIN-4-YLPYRIDO[3',2':4,5]FURO[3,2-D]PYRIMIDIN-2-YL)PHENOL, mLST8, mTOR 著者 Pavletich, N.P, Yang, H. 登録日 2013-03-22 公開日 2013-05-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 mTOR kinase structure, mechanism and regulation. Nature, 497, 2013
4JSV	mTOR kinase structure, mechanism and regulation. 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Serine/threonine-protein kinase mTOR, ... 著者 Pavletich, N.P, Yang, H. 登録日 2013-03-22 公開日 2013-05-01 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 mTOR kinase structure, mechanism and regulation. Nature, 497, 2013
4JSP	structure of mTORDeltaN-mLST8-ATPgammaS-Mg complex 分子名称: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase mTOR, ... 著者 Pavletich, N.P, Yang, H. 登録日 2013-03-22 公開日 2013-05-01 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 mTOR kinase structure, mechanism and regulation. Nature, 497, 2013
4JT5	mTORdeltaN-mLST8-pp242 complex 分子名称: 2-[4-amino-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-1H-indol-5-ol, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 著者 Pavletich, N.P, Yang, H. 登録日 2013-03-22 公開日 2013-05-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.45 Å) 主引用文献 mTOR kinase structure, mechanism and regulation. Nature, 497, 2013
4JSX	structure of mTORDeltaN-mLST8-Torin2 complex 分子名称: 9-(6-aminopyridin-3-yl)-1-[3-(trifluoromethyl)phenyl]benzo[h][1,6]naphthyridin-2(1H)-one, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 著者 Pavletich, N.P, Yang, H. 登録日 2013-03-22 公開日 2013-05-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 mTOR kinase structure, mechanism and regulation. Nature, 497, 2013
4GQB	Crystal Structure of the human PRMT5:MEP50 Complex 分子名称: (2S,5S,6E)-2,5-diamino-6-[(3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxydihydrofuran-2(3H)-ylidene]hexanoic acid, Histone H4 peptide, Methylosome protein 50, ... 著者 Antonysamy, S, Bonday, Z, Campbell, R, Doyle, B, Druzina, Z, Gheyi, T, Han, B, Jungheim, L.N, Qian, Y, Rauch, C, Russell, M, Sauder, J.M, Wasserman, S.R, Weichert, K, Willard, F.S, Zhang, A, Emtage, S. 登録日 2012-08-22 公開日 2012-10-17 最終更新日 2018-11-21 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Crystal structure of the human PRMT5:MEP50 complex. Proc.Natl.Acad.Sci.USA, 109, 2012
4KFM	Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in complex with the beta-gamma G protein subunits 分子名称: DODECYL-BETA-D-MALTOSIDE, G protein-activated inward rectifier potassium channel 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Whorton, M.R, MacKinnon, R. 登録日 2013-04-27 公開日 2013-06-12 最終更新日 2013-09-11 実験手法 X-RAY DIFFRACTION (3.45 Å) 主引用文献 X-ray structure of the mammalian GIRK2-beta gamma G-protein complex. Nature, 498, 2013
5XWR	Crystal Structure of RBBP4-peptide complex 分子名称: Histone-binding protein RBBP4, MET-SER-ARG-ARG-LYS-GLN-ALA-LYS-PRO-GLN-HIS-ILE 著者 Jobichen, C, Lui, B.H, Daniel, G.T, Sivaraman, J. 登録日 2017-06-30 公開日 2018-07-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5XXQ	Crystal structure of RBBP4: ZNF827 and its function in telomere 分子名称: Histone-binding protein RBBP4, Zinc finger protein 827 著者 Sun, A, Shi, Y. 登録日 2017-07-04 公開日 2018-08-08 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of RBBP4: ZNF827 and its function in telomere To Be Published
5Y1U	Crystal structure of RBBP4 bound to AEBP2 RRK motif 分子名称: Histone-binding protein RBBP4, SULFATE ION, Zinc finger protein AEBP2 著者 Sun, A, Li, F, Wu, J, Shi, Y. 登録日 2017-07-21 公開日 2018-04-18 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.141 Å) 主引用文献 Structural and biochemical insights into human zinc finger protein AEBP2 reveals interactions with RBBP4 Protein Cell, 2017
5TEE	Crystal structure of Gemin5 WD40 repeats in apo form 分子名称: GLYCEROL, Gem-associated protein 5, SODIUM ION, ... 著者 Chao, X, Tempel, W, Bian, C, Cerovina, T, He, H, Walker, J.R, Seitova, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2016-09-21 公開日 2016-10-19 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly. Genes Dev., 30, 2016
5TQR	ctPRC2 in an autoinhibited conformation bound to S-adenosylmethionine 分子名称: Histone-lysine N-methyltransferase EZH2, Polycomb protein SUZ12, Polycomb Protein EED, ... 著者 Bratkowski, M.A, Liu, X. 登録日 2016-10-24 公開日 2017-06-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.571 Å) 主引用文献 Polycomb repressive complex 2 in an autoinhibited state. J. Biol. Chem., 292, 2017
5U5T	Crystal structure of EED in complex with H3K27Me3 peptide and 3-(benzo[d][1,3]dioxol-4-ylmethyl)piperidine-1-carboximidamide 分子名称: (3R)-3-[(2H-1,3-benzodioxol-4-yl)methyl]piperidine-1-carboximidamide, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, ... 著者 Bussiere, D, Shu, W. 登録日 2016-12-07 公開日 2017-01-11 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase. J. Med. Chem., 60, 2017
5ZCS	4.9 Angstrom Cryo-EM structure of human mTOR complex 2 分子名称: Rapamycin-insensitive companion of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex 2 subunit MAPKAP1, ... 著者 Chen, X, Liu, M, Tian, Y, Wang, H, Wang, J, Xu, Y. 登録日 2018-02-20 公開日 2018-03-21 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4.9 Å) 主引用文献 Cryo-EM structure of human mTOR complex 2. Cell Res., 28, 2018
5U62	Crystal structure of EED in complex with H3K27Me3 peptide and 6-(benzo[d][1,3]dioxol-4-ylmethyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-3-amine 分子名称: (6S)-6-[(2H-1,3-benzodioxol-4-yl)methyl]-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-3-amine, GLYCEROL, Histone-lysine N-methyltransferase EZH2, ... 著者 Bussiere, D, Shu, W. 登録日 2016-12-07 公開日 2017-01-11 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase. J. Med. Chem., 60, 2017
5TEF	Crystal structure of Gemin5 WD40 repeats in complex with m7GpppG 分子名称: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, GLYCEROL, Gem-associated protein 5, ... 著者 Chao, X, Tempel, W, Bian, C, He, H, Cerovina, T, Seitova, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2016-09-21 公開日 2016-10-19 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly. Genes Dev., 30, 2016
5WBU	Crystal structure of mTOR(deltaN)-mLST8-PRAS40(alpha-helix & beta-strand) complex 分子名称: Proline-rich AKT1 substrate 1, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 著者 Pavletich, N.P, Yang, H. 登録日 2017-06-29 公開日 2017-12-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.42 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5WBJ	Crystal structure of the arabidopsis thaliana Raptor in complex with the TOS peptide of human 4EBP1 分子名称: Eukaryotic translation initiation factor 4E-binding protein 1, Regulatory-associated protein of TOR 1 著者 Pavletich, N.P, Jiang, X. 登録日 2017-06-29 公開日 2017-12-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5WBY	Crystal structure of mTOR(deltaN)-mLST8-PRAS40(beta-strand) complex 分子名称: Proline-rich AKT1 substrate 1, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 著者 Pavletich, N.P, Yang, H. 登録日 2017-06-29 公開日 2017-12-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5V4B	Crystal structure of the Skp1-FBXW7-DISC1 complex 分子名称: DISC1 peptide, F-box/WD repeat-containing protein 7, IMIDAZOLE, ... 著者 Li, Y, Baillie, G.S, Hao, B. 登録日 2017-03-08 公開日 2017-09-20 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system. Mol. Psychiatry, 23, 2018
5WAI	Crystal Structure of a Suz12-Rbbp4-Jarid2-Aebp2 Heterotetrameric Complex 分子名称: Histone-binding protein RBBP4, Jumonji, AT-rich interactive domain 2, ... 著者 Chen, S, Jiao, L, Liu, X. 登録日 2017-06-26 公開日 2018-03-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding. Mol. Cell, 69, 2018
5WBI	Crystal structure of the Arabidopsis thaliana Raptor 分子名称: Regulatory-associated protein of TOR 1 著者 Pavletich, N.P, Jiang, X. 登録日 2017-06-29 公開日 2017-12-20 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
5WFD	Humanized mutant of the Chaetomium thermophilum Polycomb Repressive Complex 2 bound to the inhibitor GSK126 分子名称: 1-[(2S)-butan-2-yl]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-methyl-6-[6-(piperazin-1-yl)pyridin-3-yl]-1H-indole-4-carboxamide, Histone-lysine-N-methyltransferase EZH2, Polycomb protein SUZ12 chimera, ... 著者 Bratkowski, M.A, Liu, X. 登録日 2017-07-11 公開日 2018-06-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.654 Å) 主引用文献 An Evolutionarily Conserved Structural Platform for PRC2 Inhibition by a Class of Ezh2 Inhibitors. Sci Rep, 8, 2018
5WF7	Chaetomium thermophilum Polycomb Repressive Complex 2 bound to GSK126 分子名称: 1-[(2S)-butan-2-yl]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-methyl-6-[6-(piperazin-1-yl)pyridin-3-yl]-1H-indole-4-carboxamide, Histone-lysine-N-methyltransferase EZH2, Polycomb protein SUZ12 chimera, ... 著者 Bratkowski, M.A, Liu, X. 登録日 2017-07-11 公開日 2018-06-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 An Evolutionarily Conserved Structural Platform for PRC2 Inhibition by a Class of Ezh2 Inhibitors. Sci Rep, 8, 2018

<12131415161718192021222324252627>