7YZK
| Structure of Mycobacterium tuberculosis adenylyl cyclase Rv1625c / Cya | 分子名称: | 3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATE, Adenylate cyclase, MANGANESE (II) ION, ... | 著者 | Mehta, V, Khanppnavar, B, Korkhov, V.M. | 登録日 | 2022-02-20 | 公開日 | 2022-08-31 | 実験手法 | ELECTRON MICROSCOPY (3.57 Å) | 主引用文献 | Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases. Elife, 11, 2022
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7YZI
| Structure of Mycobacterium tuberculosis adenylyl cyclase Rv1625c / Cya | 分子名称: | 3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATE, Adenylate cyclase, MANGANESE (II) ION, ... | 著者 | Mehta, V, Khanppnavar, B, Korkhov, V.M. | 登録日 | 2022-02-20 | 公開日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (3.83 Å) | 主引用文献 | Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases. Elife, 11, 2022
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7Z6C
| Crystal structure of human Dihydroorotate Dehydrogenase in complex with the inhibitor 2-Hydroxy-N-(2-ispropyl-5-methyl-4-phenoxyphenyl)pyrazolo[1,5-a]pyridine-3-carboxamide. | 分子名称: | ACETATE ION, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | 著者 | Alberti, M, Lolli, M.L, Boschi, D, Sainas, S, Rizzi, M, Ferraris, D.M, Miggiano, R. | 登録日 | 2022-03-11 | 公開日 | 2022-10-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5- a ]pyridine Scaffold: SAR of the Aryloxyaryl Moiety. J.Med.Chem., 65, 2022
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5EZ6
| Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Transforming protein RhoA | 著者 | Yan, Z, Ma, S, Zhang, Y, Ma, L, Wang, F, Li, J, Miao, L. | 登録日 | 2015-11-26 | 公開日 | 2016-12-07 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystallization and preliminary X-ray crystallographic analysis of a small GTPase RhoA To Be Published
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7EDM
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7EDN
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3BC8
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7YTJ
| Cryo-EM structure of VTC complex | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, INOSITOL HEXAKISPHOSPHATE, PHOSPHATE ION, ... | 著者 | Guan, Z.Y, Chen, J, Liu, R.W, Chen, Y.K, Xing, Q, Du, Z.M, Liu, Z. | 登録日 | 2022-08-15 | 公開日 | 2023-02-22 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | The cytoplasmic synthesis and coupled membrane translocation of eukaryotic polyphosphate by signal-activated VTC complex. Nat Commun, 14, 2023
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1KVP
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1PP7
| Crystal structure of the T. vaginalis Initiator binding protein bound to the ferredoxin Inr | 分子名称: | 39 kDa initiator binding protein, FERREDOXIN INR, ZINC ION | 著者 | Schumacher, M.A, Lau, A.O.T, Johnson, P.J. | 登録日 | 2003-06-16 | 公開日 | 2003-11-18 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Structural Basis of Core Promoter Recognition in a Primitive Eukaryote Cell(Cambridge,Mass.), 115, 2003
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2YIX
| Triazolopyridine Inhibitors of p38 | 分子名称: | 1-ethyl-3-(2-{[3-(1-methylethyl)[1,2,4]triazolo[4,3-a]pyridin-6-yl]sulfanyl}benzyl)urea, MITOGEN-ACTIVATED PROTEIN KINASE 14 | 著者 | Millan, D.S, Anderson, M, Bunnage, M.E, Burrows, J.L, Butcher, K.J, Dodd, P.G, Evans, T.J, Fairman, D.A, Han, s, Hughes, S.J, Irving, S.L, Kilty, I.C, Lemaitre, A, Lewthawaite, R.A, Mahke, A, Marr, E, Mathias, J.P, Philip, J, Phillips, C, Smith, R.T, Stefaniak, M.H, Yeadon, M. | 登録日 | 2011-05-17 | 公開日 | 2011-11-30 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Design and Synthesis of Inhaled P38 Inhibitors for the Treatment of Chronic Obstructive Pulmonary Disease. J.Med.Chem., 54, 2011
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1YBV
| STRUCTURE OF TRIHYDROXYNAPHTHALENE REDUCTASE IN COMPLEX WITH NADPH AND AN ACTIVE SITE INHIBITOR | 分子名称: | 5-METHYL-1,2,4-TRIAZOLO[3,4-B]BENZOTHIAZOLE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TRIHYDROXYNAPHTHALENE REDUCTASE | 著者 | Andersson, A, Schneider, G, Lindqvist, Y. | 登録日 | 1996-09-23 | 公開日 | 1997-10-15 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structure of the ternary complex of 1,3,8-trihydroxynaphthalene reductase from Magnaporthe grisea with NADPH and an active-site inhibitor. Structure, 4, 1996
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1PP8
| crystal structure of the T. vaginalis IBP39 Initiator binding domain (IBD) bound to the alpha-SCS Inr element | 分子名称: | 39 kDa initiator binding protein, ALPHA-SCS INR, SULFATE ION | 著者 | Schumacher, M.A, Lau, A.O.T, Johnson, P.J. | 登録日 | 2003-06-16 | 公開日 | 2003-11-18 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Structural Basis of Core Promoter Recognition in a Primitive Eukaryote Cell(Cambridge,Mass.), 115, 2003
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2LC5
| Calmodulin-like Protein from Entamoeba histolytica: Solution Structure and Calcium-Binding Properties of a Partially Folded Protein | 分子名称: | CALCIUM ION, Calmodulin, putative | 著者 | Rout, A.K, Padhan, N, Barnwal, R.P, Bhattacharya, A, Chary, K.V. | 登録日 | 2011-04-23 | 公開日 | 2011-06-08 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Calmodulin like protein from Entamoeba histolytica: solution structure and calcium binding properties of a partially folded protein. Biochemistry, 50, 2010
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1TGS
| THREE-DIMENSIONAL STRUCTURE OF THE COMPLEX BETWEEN PANCREATIC SECRETORY INHIBITOR (KAZAL TYPE) AND TRYPSINOGEN AT 1.8 ANGSTROMS RESOLUTION. STRUCTURE SOLUTION, CRYSTALLOGRAPHIC REFINEMENT AND PRELIMINARY STRUCTURAL INTERPRETATION | 分子名称: | CALCIUM ION, PANCREATIC SECRETORY TRYPSIN INHIBITOR (KAZAL TYPE), SULFATE ION, ... | 著者 | Bolognesi, M, Gatti, G, Menegatti, E, Guarneri, M, Marquart, M, Papamokos, E, Huber, R. | 登録日 | 1982-09-27 | 公開日 | 1983-01-18 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Three-dimensional structure of the complex between pancreatic secretory trypsin inhibitor (Kazal type) and trypsinogen at 1.8 A resolution. Structure solution, crystallographic refinement and preliminary structural interpretation. J.Mol.Biol., 162, 1982
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3BCA
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3B2W
| Crystal structure of pyrimidine amide 11 bound to Lck | 分子名称: | N-[5-({[2-fluoro-3-(trifluoromethyl)phenyl]amino}carbonyl)-2-methylphenyl]-4-methoxy-2-[(4-piperazin-1-ylphenyl)amino]pyrimidine-5-carboxamide, Proto-oncogene tyrosine-protein kinase LCK | 著者 | Huang, X. | 登録日 | 2007-10-19 | 公開日 | 2007-12-18 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | N-(3-(phenylcarbamoyl)arylpyrimidine)-5-carboxamides as potent and selective inhibitors of Lck: structure, synthesis and SAR. Bioorg.Med.Chem.Lett., 18, 2008
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1TMM
| Crystal structure of ternary complex of E.coli HPPK(W89A) with MGAMPCPP and 6-Hydroxymethylpterin | 分子名称: | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 6-HYDROXYMETHYLPTERIN, ACETATE ION, ... | 著者 | Blaszczyk, J, Li, Y, Wu, Y, Shi, G, Ji, X, Yan, H. | 登録日 | 2004-06-10 | 公開日 | 2005-06-21 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Is the Critical Role of Loop 3 of Escherichia coli 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase in Catalysis Due to Loop-3 Residues Arginine-84 and Tryptophan-89? Site-Directed Mutagenesis, Biochemical, and Crystallographic Studies. Biochemistry, 44, 2005
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3BCB
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5M9Q
| Human angiogenin PD variant R95Q | 分子名称: | Angiogenin, DI(HYDROXYETHYL)ETHER, SULFATE ION, ... | 著者 | Bradshaw, W.J, Rehman, S, Pham, T.T.K, Thiyagarajan, N, Lee, R.L, Subramanian, V, Acharya, K.R. | 登録日 | 2016-11-02 | 公開日 | 2017-02-22 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis. Sci Rep, 7, 2017
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7KXE
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5M9T
| Human angiogenin ALS variant H114R | 分子名称: | Angiogenin, BORATE ION, GLYCEROL | 著者 | Bradshaw, W.J, Rehman, S, Pham, T.T.K, Thiyagarajan, N, Lee, R.L, Subramanian, V, Acharya, K.R. | 登録日 | 2016-11-02 | 公開日 | 2017-02-22 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis. Sci Rep, 7, 2017
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7KXF
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5MWC
| Crystal structure of the genetically-encoded green calcium indicator NTnC in its calcium bound state | 分子名称: | CALCIUM ION, genetically-encoded green calcium indicator NTnC | 著者 | Boyko, K.M, Nikolaeva, A.Y, Korzhenevskiy, D.A, Rakitina, T.V, Popov, V.O, Subach, O.M, Barykina, N.V, Subach, F.V. | 登録日 | 2017-01-18 | 公開日 | 2018-02-14 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Enchanced variant of genetically-encoded green calcium indicator NTnC To Be Published
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5MT0
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