3B2W
Crystal structure of pyrimidine amide 11 bound to Lck
Summary for 3B2W
Entry DOI | 10.2210/pdb3b2w/pdb |
Related | 2OFV |
Descriptor | Proto-oncogene tyrosine-protein kinase LCK, N-[5-({[2-fluoro-3-(trifluoromethyl)phenyl]amino}carbonyl)-2-methylphenyl]-4-methoxy-2-[(4-piperazin-1-ylphenyl)amino]pyrimidine-5-carboxamide (3 entities in total) |
Functional Keywords | lck, kinase domain, alternative splicing, atp-binding, chromosomal rearrangement, cytoplasm, disease mutation, host-virus interaction, lipoprotein, membrane, myristate, nucleotide-binding, palmitate, phosphorylation, proto-oncogene, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P06239 |
Total number of polymer chains | 1 |
Total formula weight | 32682.26 |
Authors | Huang, X. (deposition date: 2007-10-19, release date: 2007-12-18, Last modification date: 2023-08-30) |
Primary citation | Deak, H.L.,Newcomb, J.R.,Nunes, J.J.,Boucher, C.,Cheng, A.C.,DiMauro, E.F.,Epstein, L.F.,Gallant, P.,Hodous, B.L.,Huang, X.,Lee, J.H.,Patel, V.F.,Schneider, S.,Turci, S.M.,Zhu, X. N-(3-(phenylcarbamoyl)arylpyrimidine)-5-carboxamides as potent and selective inhibitors of Lck: structure, synthesis and SAR. Bioorg.Med.Chem.Lett., 18:1172-1176, 2008 Cited by PubMed: 18083554DOI: 10.1016/j.bmcl.2007.11.123 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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