5MT0
COMPLEMENT FACTOR D IN COMPLEX WITH A REVERSIBLE INDOLE CARBOXYLIC ACID BASED INHIBITOR
Summary for 5MT0
Entry DOI | 10.2210/pdb5mt0/pdb |
Descriptor | Complement factor D, 5-fluoranyl-3-[[(1~{S},2~{S})-2-phenylcyclopropyl]carbonylamino]-1~{H}-indole-2-carboxylic acid, SULFATE ION, ... (4 entities in total) |
Functional Keywords | hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 25173.52 |
Authors | Mac Sweeney, A.,Ostermann, N. (deposition date: 2017-01-06, release date: 2017-02-15, Last modification date: 2024-05-01) |
Primary citation | Vulpetti, A.,Randl, S.,Rudisser, S.,Ostermann, N.,Erbel, P.,Mac Sweeney, A.,Zoller, T.,Salem, B.,Gerhartz, B.,Cumin, F.,Hommel, U.,Dalvit, C.,Lorthiois, E.,Maibaum, J. Structure-Based Library Design and Fragment Screening for the Identification of Reversible Complement Factor D Protease Inhibitors. J. Med. Chem., 60:1946-1958, 2017 Cited by PubMed: 28157311DOI: 10.1021/acs.jmedchem.6b01684 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.29 Å) |
Structure validation
Download full validation report