4AV1
| Crystal structure of the human PARP-1 DNA binding domain in complex with DNA | 分子名称: | 5'-D(*AP*AP*GP*TP*GP*TP*TP*GP*CP*AP*TP*TP)-3', 5'-D(*TP*AP*AP*TP*GP*CP*AP*AP*CP*AP*CP*TP)-3', POLY [ADP-RIBOSE] POLYMERASE 1, ... | 著者 | Ali, A.A.E, Timinszky, G, Arribas-Bosacoma, R, Kozlowski, M, Hassa, P.O, Hassler, M, Ladurner, A.G, Pearl, L.H, Oliver, A.W. | 登録日 | 2012-05-23 | 公開日 | 2012-06-13 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | The Zinc-Finger Domains of Parp1 Cooperate to Recognise DNA Strand-Breaks Nat.Struct.Mol.Biol., 19, 2012
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3WE3
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4AU7
| The structure of the Suv4-20h2 ternary complex with histone H4 | 分子名称: | 1,2-ETHANEDIOL, HISTONE H4 PEPTIDE, HISTONE-LYSINE N-METHYLTRANSFERASE SUV420H2, ... | 著者 | Southall, S.M, Cronin, N.B, Wilson, J.R. | 登録日 | 2012-05-14 | 公開日 | 2013-05-22 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | A Novel Route to Product Specificity in the Suv4-20 Family of Histone H4K20 Methyltransferases. Nucleic Acids Res., 42, 2014
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8H0J
| Annexin A5 mutant | 分子名称: | Annexin A5, CALCIUM ION | 著者 | Hua, Z.C, Tang, W. | 登録日 | 2022-09-29 | 公開日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | structure dissection of the membrane aggregation mechanism induced by Annexin A5 mutation To Be Published
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6HT7
| Crystal structure of the WT human mitochondrial chaperonin (ADP:BeF3)14 complex | 分子名称: | 10 kDa heat shock protein, mitochondrial, 60 kDa heat shock protein, ... | 著者 | Jebara, F, Patra, M, Azem, A, Hirsch, J. | 登録日 | 2018-10-03 | 公開日 | 2020-04-29 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | 主引用文献 | Crystal structure of the WT human mitochondrial football Hsp60-Hsp10(ADPBeFx)14 complex Nat Commun, 2020
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6HVO
| Crystal structure of human PCNA in complex with three peptides of p12 subunit of human polymerase delta | 分子名称: | DNA polymerase delta subunit 4, Proliferating cell nuclear antigen, SULFATE ION | 著者 | Gonzalez-Magana, A, Romano-Moreno, M, Rojas, A.L, Blanco, F.J, De Biasio, A. | 登録日 | 2018-10-11 | 公開日 | 2019-01-23 | 最終更新日 | 2019-03-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The p12 subunit of human polymerase delta uses an atypical PIP box for molecular recognition of proliferating cell nuclear antigen (PCNA). J.Biol.Chem., 294, 2019
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8HLW
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8HQY
| Cryo-EM structure of SSX1 bound to the H2AK119Ub nucleosome at a resolution of 3.05 angstrom | 分子名称: | DNA (136-MER), DNA (137-MER), Histone H2A type 1-B/E, ... | 著者 | Zebin, T, Ai, H.S, Ziyu, X, GuoChao, C, Man, P, Liu, L. | 登録日 | 2022-12-14 | 公開日 | 2023-09-27 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes. Nat.Struct.Mol.Biol., 31, 2024
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6I0M
| Structure of human IMP dehydrogenase, isoform 2, bound to GDP | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-MONOPHOSPHATE, Inosine-5'-monophosphate dehydrogenase 2, ... | 著者 | Buey, R.M, Fernandez-Justel, D, Revuelta, J.L. | 登録日 | 2018-10-26 | 公開日 | 2019-01-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.567 Å) | 主引用文献 | A Nucleotide-Dependent Conformational Switch Controls the Polymerization of Human IMP Dehydrogenases to Modulate their Catalytic Activity. J. Mol. Biol., 431, 2019
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8GYC
| Annexin A5 protein dimer mutant | 分子名称: | Annexin A5, CALCIUM ION | 著者 | Hua, Z.C, Tang, W. | 登録日 | 2022-09-22 | 公開日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | structure dissection of the membrane aggregation mechanism induced by Annexin A5 mutation To Be Published
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6I0O
| Structure of human IMP dehydrogenase, isoform 2, bound to GTP | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, Inosine-5'-monophosphate dehydrogenase 2, SULFATE ION | 著者 | Buey, R.M, Fernandez-Justel, D, Revuelta, J.L. | 登録日 | 2018-10-26 | 公開日 | 2019-01-30 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.623 Å) | 主引用文献 | A Nucleotide-Dependent Conformational Switch Controls the Polymerization of Human IMP Dehydrogenases to Modulate their Catalytic Activity. J. Mol. Biol., 431, 2019
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8H3H
| Human ATAD2 Walker B mutant, ATP state | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATPase family AAA domain-containing protein 2 | 著者 | Cho, C, Song, J. | 登録日 | 2022-10-08 | 公開日 | 2023-10-18 | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | 主引用文献 | Structure of the human ATAD2 AAA+ histone chaperone reveals mechanism of regulation and inter-subunit communication. Commun Biol, 6, 2023
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8HQ6
| KL2 in complex with CRM1-Ran-RanBP1 | 分子名称: | CHLORIDE ION, CRM1 isoform 1, DIMETHYL SULFOXIDE, ... | 著者 | Sun, Q, Jian, L. | 登録日 | 2022-12-13 | 公開日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors. J.Med.Chem., 66, 2023
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8HQ3
| KL1 in complex with CRM1-Ran-RanBP1 | 分子名称: | CHLORIDE ION, CRM1 isoform 1, DIMETHYL SULFOXIDE, ... | 著者 | Sun, Q, Jian, L. | 登録日 | 2022-12-13 | 公開日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors. J.Med.Chem., 66, 2023
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6I0Z
| CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 1 | 分子名称: | Fascin, ~{N}-(2,4-dichlorophenyl)-~{N}-methyl-ethanamide | 著者 | Schuettelkopf, A.W. | 登録日 | 2018-10-27 | 公開日 | 2019-02-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents. Bioorg.Med.Chem.Lett., 29, 2019
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6I13
| CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 7 | 分子名称: | 1,2-ETHANEDIOL, 2-[(3-chlorophenyl)methyl]-~{N}-(1-methylpyrazol-4-yl)-1-oxidanylidene-isoquinoline-4-carboxamide, ACETATE ION, ... | 著者 | Schuettelkopf, A.W. | 登録日 | 2018-10-27 | 公開日 | 2019-02-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents. Bioorg.Med.Chem.Lett., 29, 2019
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8H9Z
| Annexin A5 protein mutant | 分子名称: | Annexin A5, CALCIUM ION | 著者 | Hua, Z.C, Tang, W. | 登録日 | 2022-10-26 | 公開日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | structure dissection of the membrane aggregation mechanism induced by Annexin A5 mutation To Be Published
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8HE7
| ADP-ribosyltransferase 1 (PARP1) catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor | 分子名称: | 1-[[4-fluoranyl-3-(3-oxidanylidene-4-pentan-3-yl-piperazin-1-yl)carbonyl-phenyl]methyl]quinazoline-2,4-dione, Poly [ADP-ribose] polymerase 1, processed C-terminus, ... | 著者 | Wang, X.Y, Zhou, J, Xu, B.L. | 登録日 | 2022-11-07 | 公開日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Discovery of Quinazoline-2,4(1 H ,3 H )-dione Derivatives Containing a Piperizinone Moiety as Potent PARP-1/2 Inhibitors─Design, Synthesis, In Vivo Antitumor Activity, and X-ray Crystal Structure Analysis. J.Med.Chem., 66, 2023
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6I42
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6I17
| CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 24 | 分子名称: | 1,2-ETHANEDIOL, 2-[(3,4-dichlorophenyl)methyl]-~{N}-(1-methylpyrazol-4-yl)-1-oxidanylidene-6-piperidin-4-yl-2,7-naphthyridine-4-carboxamide, ACETATE ION, ... | 著者 | Schuettelkopf, A.W. | 登録日 | 2018-10-27 | 公開日 | 2019-02-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents. Bioorg.Med.Chem.Lett., 29, 2019
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6IGX
| Crystal structure of human CAP-G in complex with CAP-H | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Condensin complex subunit 2, Condensin complex subunit 3 | 著者 | Hara, K, Migita, T, Shimizu, K, Hashimoto, H. | 登録日 | 2018-09-26 | 公開日 | 2019-03-13 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.995 Å) | 主引用文献 | Structural basis of HEAT-kleisin interactions in the human condensin I subcomplex. Embo Rep., 20, 2019
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8HQ4
| B27 in complex with CRM1-Ran-RanBP1 | 分子名称: | 3-[(4-fluorophenyl)carbonylamino]-4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]benzoic acid, CHLORIDE ION, CRM1 isoform 1, ... | 著者 | Lei, Y, Sun, Q. | 登録日 | 2022-12-13 | 公開日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | B27 in complex with CRM1-Ran-RanBP1 To Be Published
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6IQ6
| Crystal structure of GAPDH | 分子名称: | (2Z)-4-methoxy-4-oxobut-2-enoic acid, Glyceraldehyde-3-phosphate dehydrogenase | 著者 | Park, J.B, Park, H.Y. | 登録日 | 2018-11-06 | 公開日 | 2019-08-28 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Structural Study of Monomethyl Fumarate-Bound Human GAPDH. Mol.Cells, 42, 2019
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6I16
| CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 15 | 分子名称: | 6-[(3,4-dichlorophenyl)methyl]-~{N}-(1-methylpyrazol-4-yl)-5-oxidanylidene-1,6-naphthyridine-8-carboxamide, ACETATE ION, Fascin | 著者 | Schuettelkopf, A.W. | 登録日 | 2018-10-27 | 公開日 | 2019-02-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents. Bioorg.Med.Chem.Lett., 29, 2019
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8HQ5
| G6 in complex with CRM1-Ran-RanBP1 | 分子名称: | 3-[(4-bromophenyl)carbonylamino]-4-[4-(5-chloranyl-2-methyl-phenyl)piperazin-1-yl]benzoic acid, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, ... | 著者 | Sun, Q, Lei, Y. | 登録日 | 2022-12-13 | 公開日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | F1 in complex with CRM1-Ran-RanBP1 To Be Published
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