PDB: 5470 件ウェブページステータス検索Chemie searchBIRD

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5Z9C	Solution NMR structures of BRD4 first bromodomain with small compound MMQO 分子名称: 8-methoxy-6-methylquinolin-4(1H)-one, Bromodomain-containing protein 4 著者 Zeng, L, Zhou, M.-M. 登録日 2018-02-02 公開日 2018-02-14 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 A New Quinoline BRD4 Inhibitor Targets a Distinct Latent HIV-1 Reservoir for Reactivation from Other "Shock" Drugs. J. Virol., 92, 2018
6A3A	MVM NES mutant Nm2 in complex with CRM1-Ran-RanBP1 分子名称: 1,2-ETHANEDIOL, Exportin-1, GLYCEROL, ... 著者 Sun, Q, Li, Y. 登録日 2018-06-15 公開日 2019-06-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor. Int J Nanomedicine, 16, 2021
6A3E	MVM NES mutant Nm15 in complex with CRM1-Ran-RanBP1 分子名称: Exportin-1, GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Sun, Q, Li, Y. 登録日 2018-06-15 公開日 2019-06-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor. Int J Nanomedicine, 16, 2021
6A5Q	Structure of 14-3-3 beta in complex with TFEB 14-3-3 binding motif 分子名称: 14-3-3 protein beta/alpha, MALONIC ACID, TFEB pS211-peptide 著者 Xu, Y, Ren, J.Q, Feng, W. 登録日 2018-06-25 公開日 2019-02-13 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization. Autophagy, 15, 2019
6A3C	MVM NES mutant Nm12 in complex with CRM1-Ran-RanBP1 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... 著者 Sun, Q, Li, Y. 登録日 2018-06-15 公開日 2019-06-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor. Int J Nanomedicine, 16, 2021
6ADE	Crystal structure of phosphorylated mutant of glyceraldehyde 3-phosphate dehydrogenase from human placenta at 3.15A resolution 分子名称: Glyceraldehyde-3-phosphate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Dilawari, R, Singh, P.K, Raje, M, Sharma, S, Singh, T.P. 登録日 2018-07-31 公開日 2018-08-22 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Crystal structure of phosphorylated mutant of glyceraldehyde 3-phosphate dehydrogenase from human placenta at 3.15A resolution To Be Published
6A3B	MVM NES mutant Nm13 in complex with CRM1-Ran-RanBP1 分子名称: 1,2-ETHANEDIOL, Exportin-1, GLYCEROL, ... 著者 Sun, Q, Li, Y. 登録日 2018-06-15 公開日 2019-06-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor. Int J Nanomedicine, 16, 2021
6AC9	Crystal structure of human Vaccinia-related kinase 1 (VRK1) in complex with AMP-PNP 分子名称: CHLORIDE ION, GLYCEROL, MAGNESIUM ION, ... 著者 Ngow, Y.S, Sreekanth, R, Yoon, H.S. 登録日 2018-07-25 公開日 2018-12-26 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Crystal structure of human vaccinia-related kinase 1 in complex with AMP-PNP, a non-hydrolyzable ATP analog. Protein Sci., 28, 2019
6AJV	Crystal structure of BRD4 in complex with isoliquiritigenin and DMSO (Cocktail No. 3) 分子名称: 2',4,4'-TRIHYDROXYCHALCONE, Bromodomain-containing protein 4, DIMETHYL SULFOXIDE, ... 著者 Yokoyama, T, Matsumoto, K, Nabeshima, Y, Mizuguchi, M. 登録日 2018-08-28 公開日 2019-06-12 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structural and thermodynamic characterization of the binding of isoliquiritigenin to the first bromodomain of BRD4. Febs J., 286, 2019
6AJY	Crystal structure of BRD4 in complex with 2',4'-dihydroxy-2-methoxychalcone 分子名称: 2',4'-dihydroxy-2-methoxychalcone, Bromodomain-containing protein 4, SODIUM ION 著者 Yokoyama, T, Matsumoto, K, Nabeshima, Y, Mizuguchi, M. 登録日 2018-08-28 公開日 2019-06-12 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural and thermodynamic characterization of the binding of isoliquiritigenin to the first bromodomain of BRD4. Febs J., 286, 2019
6B9M	Crystal structure of UHRF1 TTD domain in complex with the polybasic region 分子名称: E3 ubiquitin-protein ligase UHRF1 著者 Song, J, Tan, X. 登録日 2017-10-10 公開日 2018-02-14 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 An Intramolecular Interaction of UHRF1 Reveals Dual Control for Its Histone Association. Structure, 26, 2018
5YUF	Crystal Structure of PML RING tetramer 分子名称: Protein PML, ZINC ION 著者 Wang, P, Benhend, S, Wu, H, Breitenbach, V, Zhen, T, Jollivet, F, Peres, L, Li, Y, Chen, S, Chen, Z, de THE, H, Meng, G. 登録日 2017-11-22 公開日 2018-04-11 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 RING tetramerization is required for nuclear body biogenesis and PML sumoylation. Nat Commun, 9, 2018
5Z8R	BRD4 Bromodomain 1 with an inhibitor 分子名称: 1-ethyl-6-[(3S)-3-oxidanylpiperidin-1-yl]sulfonyl-benzo[cd]indol-2-one, Bromodomain-containing protein 4 著者 Xiao, S, Chen, S, Chen, H. 登録日 2018-02-01 公開日 2019-02-06 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 BRD4 Bromodomain 1 with an inhibitor To Be Published
5ZJD	Lactate dehydrogenase with NADH and MLA 分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, L-lactate dehydrogenase A chain, MALONATE ION 著者 Han, C.W, Jang, S.B. 登録日 2018-03-20 公開日 2019-07-24 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.394 Å) 主引用文献 Machilin A Inhibits Tumor Growth and Macrophage M2 Polarization Through the Reduction of Lactic Acid. Cancers (Basel), 11, 2019
5YU6	CRYSTAL STRUCTURE OF EXPORTIN-5:RANGTP COMPLEX 分子名称: 13-mer peptide, Exportin-5, GTP-binding nuclear protein Ran, ... 著者 Yamazawa, R, Jiko, C, Lee, S.J, Yamashita, E. 登録日 2017-11-20 公開日 2018-08-29 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.997 Å) 主引用文献 Structural Basis for Selective Binding of Export Cargoes by Exportin-5 Structure, 26, 2018
5YY9	Crystal structure of Tandem Tudor Domain of human UHRF1 in complex with LIG1-K126me3 分子名称: E3 ubiquitin-protein ligase UHRF1, Ligase 1 著者 Kori, S, Defossez, P.A, Arita, K. 登録日 2017-12-08 公開日 2018-12-12 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.653 Å) 主引用文献 Structure of the UHRF1 Tandem Tudor Domain Bound to a Methylated Non-histone Protein, LIG1, Reveals Rules for Binding and Regulation. Structure, 27, 2019
6BAX	Lactate Dehydrogenase in complex with inhibitor 6-(3-aminophenyl)-3-((2-chlorophenyl)thio)-4-hydroxy-6-(thiophen-3-yl)-5,6-dihydro-2H-pyran-2-one 分子名称: (6R)-6-(3-aminophenyl)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(thiophen-3-yl)-5,6-dihydro-2H-pyran-2-one, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, L-lactate dehydrogenase A chain, ... 著者 Ultsch, M, Eigenbrot, C. 登録日 2017-10-16 公開日 2018-10-24 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase To Be Published
5YYA	Crystal structure of Tandem Tudor Domain of human UHRF1 分子名称: 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase UHRF1, SULFATE ION 著者 Kori, S, Defossez, P.A, Arita, K. 登録日 2017-12-08 公開日 2018-12-12 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure of the UHRF1 Tandem Tudor Domain Bound to a Methylated Non-histone Protein, LIG1, Reveals Rules for Binding and Regulation. Structure, 27, 2019
6ASY	BiP-ATP2 分子名称: 78 kDa glucose-regulated protein, ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, ... 著者 Liu, Q, Yang, J, Zong, Y, Columbus, L, Zhou, L. 登録日 2017-08-26 公開日 2017-12-06 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Conformation transitions of the polypeptide-binding pocket support an active substrate release from Hsp70s. Nat Commun, 8, 2017
6B1G	Solution structure of TDP-43 N-terminal domain dimer. 分子名称: TAR DNA-binding protein 43, S48E Mutant, Y4R Mutant 著者 Naik, M.T, Wang, A, Conicella, A, Fawzi, N.L. 登録日 2017-09-18 公開日 2018-02-28 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing. EMBO J., 37, 2018
6BB3	Lactate Dehydrogenase in complex with inhibitor 3-((2-chlorophenyl)thio)-6-(6-((4-fluorophenyl)amino)pyridin-2-yl)-4-hydroxy-6-(thiophen-3-yl)-5,6-dihydro-2H-pyran-2-one 分子名称: (6R)-3-[(2-chlorophenyl)sulfanyl]-6-{6-[(4-fluorophenyl)amino]pyridin-2-yl}-4-hydroxy-6-(thiophen-3-yl)-5,6-dihydro-2H-pyran-2-one, L-lactate dehydrogenase A chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... 著者 Chen, Z, Eigenbrot, C. 登録日 2017-10-16 公開日 2018-10-24 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase To Be Published
6BCR	Complex of 14-3-3 theta with an IRSp53 peptide phosphorylated at T340 分子名称: 1,2-ETHANEDIOL, 14-3-3 protein theta, DI(HYDROXYETHYL)ETHER, ... 著者 Kast, D.J, Dominguez, R. 登録日 2017-10-20 公開日 2018-10-24 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.986 Å) 主引用文献 Mechanism of IRSp53 inhibition by 14-3-3. Nat Commun, 10, 2019
6B0T	Structural Insights into the Induced-fit Inhibition of Fascin by a Small Molecule 分子名称: 4-methyl-N-(1-{[4-(trifluoromethyl)phenyl]methyl}-1H-indazol-3-yl)-1,2-oxazole-5-carboxamide, Fascin 著者 Dey, R, Huang, X.Y. 登録日 2017-09-15 公開日 2018-04-18 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural Insights into the Induced-fit Inhibition of Fascin by a Small-Molecule Inhibitor. J. Mol. Biol., 430, 2018
5ZPU	LFS829 in complex with CRM1-Ran-RanBP1 分子名称: (Z)-{[(3E)-4-{(R)-[3,5-bis(trifluoromethyl)phenyl]sulfinyl}but-3-en-1-yl]imino}methanethiol, CHLORIDE ION, Exportin-1,Exportin-1, ... 著者 Sun, Q, Lei, Y. 登録日 2018-04-16 公開日 2019-04-17 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 To be published To Be Published
6BB1	Lactate Dehydrogenase in complex with inhibitor (R)-5-((2-chlorophenyl)thio)-6'-(4-fluorophenoxy)-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro-[2,2'-bipyridin]-6(1H)-one 分子名称: (2R)-5-[(2-chlorophenyl)sulfanyl]-6'-(4-fluorophenoxy)-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro[2,2'-bipyridin]-6(1H)-one, L-lactate dehydrogenase A chain, LACTIC ACID, ... 著者 Ultsch, M, Eigenbrot, C. 登録日 2017-10-16 公開日 2018-10-24 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase To Be Published

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