6A3C

MVM NES mutant Nm12 in complex with CRM1-Ran-RanBP1

Summary for 6A3C

Entry DOI	10.2210/pdb6a3c/pdb
Descriptor	GTP-binding nuclear protein Ran, SODIUM ION, Ran-specific GTPase-activating protein 1, ... (11 entities in total)
Functional Keywords	transport protein, nuclear export, complex, mutant, inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	161100.96
Authors	Sun, Q.,Li, Y. (deposition date: 2018-06-15, release date: 2019-06-19, Last modification date: 2023-11-22)
Primary citation	Sui, M.,Xiong, M.,Li, Y.,Zhou, Q.,Shen, X.,Jia, D.,Gou, M.,Sun, Q. Cancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor. Int J Nanomedicine, 16:2833-2847, 2021 Cited by PubMed Abstract: Peptides can be rationally designed as non-covalent inhibitors for molecularly targeted therapy. However, it remains challenging to efficiently deliver the peptides into the targeted cells, which often severely affects their therapeutic efficiency. PubMed: 33883894 DOI: 10.2147/IJN.S266398 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation