6B0T
Structural Insights into the Induced-fit Inhibition of Fascin by a Small Molecule
Summary for 6B0T
Entry DOI | 10.2210/pdb6b0t/pdb |
Descriptor | Fascin, 4-methyl-N-(1-{[4-(trifluoromethyl)phenyl]methyl}-1H-indazol-3-yl)-1,2-oxazole-5-carboxamide (3 entities in total) |
Functional Keywords | metastaic cancers, small-molecule inhibitors, actin-bundling, domain rotation, protein binding |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 6 |
Total formula weight | 326559.58 |
Authors | Dey, R.,Huang, X.Y. (deposition date: 2017-09-15, release date: 2018-04-18, Last modification date: 2023-10-04) |
Primary citation | Huang, J.,Dey, R.,Wang, Y.,Jakoncic, J.,Kurinov, I.,Huang, X.Y. Structural Insights into the Induced-fit Inhibition of Fascin by a Small-Molecule Inhibitor. J. Mol. Biol., 430:1324-1335, 2018 Cited by PubMed: 29573988DOI: 10.1016/j.jmb.2018.03.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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