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6B0T

Structural Insights into the Induced-fit Inhibition of Fascin by a Small Molecule

Functional Information from GO Data
ChainGOidnamespacecontents
A0001725cellular_componentstress fiber
A0001726cellular_componentruffle
A0002102cellular_componentpodosome
A0003723molecular_functionRNA binding
A0003779molecular_functionactin binding
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005902cellular_componentmicrovillus
A0005911cellular_componentcell-cell junction
A0005938cellular_componentcell cortex
A0007015biological_processactin filament organization
A0007043biological_processcell-cell junction assembly
A0007163biological_processestablishment or maintenance of cell polarity
A0008144molecular_functionobsolete drug binding
A0010592biological_processpositive regulation of lamellipodium assembly
A0015629cellular_componentactin cytoskeleton
A0016477biological_processcell migration
A0030027cellular_componentlamellipodium
A0030035biological_processmicrospike assembly
A0030036biological_processactin cytoskeleton organization
A0030046biological_processparallel actin filament bundle assembly
A0030175cellular_componentfilopodium
A0030426cellular_componentgrowth cone
A0030674molecular_functionprotein-macromolecule adaptor activity
A0031253cellular_componentcell projection membrane
A0032534biological_processregulation of microvillus assembly
A0032956biological_processregulation of actin cytoskeleton organization
A0035089biological_processestablishment of apical/basal cell polarity
A0042995cellular_componentcell projection
A0044393cellular_componentmicrospike
A0045296molecular_functioncadherin binding
A0048870biological_processcell motility
A0051015molecular_functionactin filament binding
A0051017biological_processactin filament bundle assembly
A0051491biological_processpositive regulation of filopodium assembly
A0070062cellular_componentextracellular exosome
A0070161cellular_componentanchoring junction
A0071803biological_processpositive regulation of podosome assembly
A0090091biological_processpositive regulation of extracellular matrix disassembly
B0001725cellular_componentstress fiber
B0001726cellular_componentruffle
B0002102cellular_componentpodosome
B0003723molecular_functionRNA binding
B0003779molecular_functionactin binding
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005902cellular_componentmicrovillus
B0005911cellular_componentcell-cell junction
B0005938cellular_componentcell cortex
B0007015biological_processactin filament organization
B0007043biological_processcell-cell junction assembly
B0007163biological_processestablishment or maintenance of cell polarity
B0008144molecular_functionobsolete drug binding
B0010592biological_processpositive regulation of lamellipodium assembly
B0015629cellular_componentactin cytoskeleton
B0016477biological_processcell migration
B0030027cellular_componentlamellipodium
B0030035biological_processmicrospike assembly
B0030036biological_processactin cytoskeleton organization
B0030046biological_processparallel actin filament bundle assembly
B0030175cellular_componentfilopodium
B0030426cellular_componentgrowth cone
B0030674molecular_functionprotein-macromolecule adaptor activity
B0031253cellular_componentcell projection membrane
B0032534biological_processregulation of microvillus assembly
B0032956biological_processregulation of actin cytoskeleton organization
B0035089biological_processestablishment of apical/basal cell polarity
B0042995cellular_componentcell projection
B0044393cellular_componentmicrospike
B0045296molecular_functioncadherin binding
B0048870biological_processcell motility
B0051015molecular_functionactin filament binding
B0051017biological_processactin filament bundle assembly
B0051491biological_processpositive regulation of filopodium assembly
B0070062cellular_componentextracellular exosome
B0070161cellular_componentanchoring junction
B0071803biological_processpositive regulation of podosome assembly
B0090091biological_processpositive regulation of extracellular matrix disassembly
C0001725cellular_componentstress fiber
C0001726cellular_componentruffle
C0002102cellular_componentpodosome
C0003723molecular_functionRNA binding
C0003779molecular_functionactin binding
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005902cellular_componentmicrovillus
C0005911cellular_componentcell-cell junction
C0005938cellular_componentcell cortex
C0007015biological_processactin filament organization
C0007043biological_processcell-cell junction assembly
C0007163biological_processestablishment or maintenance of cell polarity
C0008144molecular_functionobsolete drug binding
C0010592biological_processpositive regulation of lamellipodium assembly
C0015629cellular_componentactin cytoskeleton
C0016477biological_processcell migration
C0030027cellular_componentlamellipodium
C0030035biological_processmicrospike assembly
C0030036biological_processactin cytoskeleton organization
C0030046biological_processparallel actin filament bundle assembly
C0030175cellular_componentfilopodium
C0030426cellular_componentgrowth cone
C0030674molecular_functionprotein-macromolecule adaptor activity
C0031253cellular_componentcell projection membrane
C0032534biological_processregulation of microvillus assembly
C0032956biological_processregulation of actin cytoskeleton organization
C0035089biological_processestablishment of apical/basal cell polarity
C0042995cellular_componentcell projection
C0044393cellular_componentmicrospike
C0045296molecular_functioncadherin binding
C0048870biological_processcell motility
C0051015molecular_functionactin filament binding
C0051017biological_processactin filament bundle assembly
C0051491biological_processpositive regulation of filopodium assembly
C0070062cellular_componentextracellular exosome
C0070161cellular_componentanchoring junction
C0071803biological_processpositive regulation of podosome assembly
C0090091biological_processpositive regulation of extracellular matrix disassembly
D0001725cellular_componentstress fiber
D0001726cellular_componentruffle
D0002102cellular_componentpodosome
D0003723molecular_functionRNA binding
D0003779molecular_functionactin binding
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005902cellular_componentmicrovillus
D0005911cellular_componentcell-cell junction
D0005938cellular_componentcell cortex
D0007015biological_processactin filament organization
D0007043biological_processcell-cell junction assembly
D0007163biological_processestablishment or maintenance of cell polarity
D0008144molecular_functionobsolete drug binding
D0010592biological_processpositive regulation of lamellipodium assembly
D0015629cellular_componentactin cytoskeleton
D0016477biological_processcell migration
D0030027cellular_componentlamellipodium
D0030035biological_processmicrospike assembly
D0030036biological_processactin cytoskeleton organization
D0030046biological_processparallel actin filament bundle assembly
D0030175cellular_componentfilopodium
D0030426cellular_componentgrowth cone
D0030674molecular_functionprotein-macromolecule adaptor activity
D0031253cellular_componentcell projection membrane
D0032534biological_processregulation of microvillus assembly
D0032956biological_processregulation of actin cytoskeleton organization
D0035089biological_processestablishment of apical/basal cell polarity
D0042995cellular_componentcell projection
D0044393cellular_componentmicrospike
D0045296molecular_functioncadherin binding
D0048870biological_processcell motility
D0051015molecular_functionactin filament binding
D0051017biological_processactin filament bundle assembly
D0051491biological_processpositive regulation of filopodium assembly
D0070062cellular_componentextracellular exosome
D0070161cellular_componentanchoring junction
D0071803biological_processpositive regulation of podosome assembly
D0090091biological_processpositive regulation of extracellular matrix disassembly
E0001725cellular_componentstress fiber
E0001726cellular_componentruffle
E0002102cellular_componentpodosome
E0003723molecular_functionRNA binding
E0003779molecular_functionactin binding
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005856cellular_componentcytoskeleton
E0005902cellular_componentmicrovillus
E0005911cellular_componentcell-cell junction
E0005938cellular_componentcell cortex
E0007015biological_processactin filament organization
E0007043biological_processcell-cell junction assembly
E0007163biological_processestablishment or maintenance of cell polarity
E0008144molecular_functionobsolete drug binding
E0010592biological_processpositive regulation of lamellipodium assembly
E0015629cellular_componentactin cytoskeleton
E0016477biological_processcell migration
E0030027cellular_componentlamellipodium
E0030035biological_processmicrospike assembly
E0030036biological_processactin cytoskeleton organization
E0030046biological_processparallel actin filament bundle assembly
E0030175cellular_componentfilopodium
E0030426cellular_componentgrowth cone
E0030674molecular_functionprotein-macromolecule adaptor activity
E0031253cellular_componentcell projection membrane
E0032534biological_processregulation of microvillus assembly
E0032956biological_processregulation of actin cytoskeleton organization
E0035089biological_processestablishment of apical/basal cell polarity
E0042995cellular_componentcell projection
E0044393cellular_componentmicrospike
E0045296molecular_functioncadherin binding
E0048870biological_processcell motility
E0051015molecular_functionactin filament binding
E0051017biological_processactin filament bundle assembly
E0051491biological_processpositive regulation of filopodium assembly
E0070062cellular_componentextracellular exosome
E0070161cellular_componentanchoring junction
E0071803biological_processpositive regulation of podosome assembly
E0090091biological_processpositive regulation of extracellular matrix disassembly
F0001725cellular_componentstress fiber
F0001726cellular_componentruffle
F0002102cellular_componentpodosome
F0003723molecular_functionRNA binding
F0003779molecular_functionactin binding
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0005902cellular_componentmicrovillus
F0005911cellular_componentcell-cell junction
F0005938cellular_componentcell cortex
F0007015biological_processactin filament organization
F0007043biological_processcell-cell junction assembly
F0007163biological_processestablishment or maintenance of cell polarity
F0008144molecular_functionobsolete drug binding
F0010592biological_processpositive regulation of lamellipodium assembly
F0015629cellular_componentactin cytoskeleton
F0016477biological_processcell migration
F0030027cellular_componentlamellipodium
F0030035biological_processmicrospike assembly
F0030036biological_processactin cytoskeleton organization
F0030046biological_processparallel actin filament bundle assembly
F0030175cellular_componentfilopodium
F0030426cellular_componentgrowth cone
F0030674molecular_functionprotein-macromolecule adaptor activity
F0031253cellular_componentcell projection membrane
F0032534biological_processregulation of microvillus assembly
F0032956biological_processregulation of actin cytoskeleton organization
F0035089biological_processestablishment of apical/basal cell polarity
F0042995cellular_componentcell projection
F0044393cellular_componentmicrospike
F0045296molecular_functioncadherin binding
F0048870biological_processcell motility
F0051015molecular_functionactin filament binding
F0051017biological_processactin filament bundle assembly
F0051491biological_processpositive regulation of filopodium assembly
F0070062cellular_componentextracellular exosome
F0070161cellular_componentanchoring junction
F0071803biological_processpositive regulation of podosome assembly
F0090091biological_processpositive regulation of extracellular matrix disassembly
Functional Information from PDB Data
site_idAC1
Number of Residues11
Detailsbinding site for residue C7V A 501
ChainResidue
APHE14
AARG217
ASER218
ALEU16
ALEU48
AGLN50
ALEU62
ATRP101
ALEU103
AGLU215
APHE216

site_idAC2
Number of Residues11
Detailsbinding site for residue C7V B 501
ChainResidue
BPHE14
BLEU16
BLEU48
BGLN50
BTRP101
BLEU103
BLEU214
BGLU215
BPHE216
BARG217
BSER218

site_idAC3
Number of Residues11
Detailsbinding site for residue C7V C 501
ChainResidue
CLEU16
CLEU48
CGLN50
CILE93
CTRP101
CLEU103
CLEU214
CGLU215
CPHE216
CARG217
CSER218

site_idAC4
Number of Residues12
Detailsbinding site for residue C7V D 501
ChainResidue
DLEU16
DLEU48
DGLN50
DVAL60
DLEU62
DTRP101
DLEU103
DVAL134
DLEU214
DGLU215
DPHE216
DARG217

site_idAC5
Number of Residues13
Detailsbinding site for residue C7V E 501
ChainResidue
EGLN11
EPHE14
ELEU16
ELEU48
EGLN50
EILE93
ETRP101
ELEU103
ELEU214
EGLU215
EPHE216
EARG217
ESER218

site_idAC6
Number of Residues12
Detailsbinding site for residue C7V F 501
ChainResidue
FPHE14
FLEU16
FLEU48
FGLN50
FTRP101
FLEU103
FVAL134
FLEU214
FGLU215
FPHE216
FARG217
FSER218

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
ASER38
BSER38
CSER38
DSER38
ESER38
FSER38

site_idSWS_FT_FI2
Number of Residues6
DetailsMOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8999969, ECO:0000305|PubMed:22155786
ChainResidueDetails
ASER39
BSER39
CSER39
DSER39
ESER39
FSER39

site_idSWS_FT_FI3
Number of Residues6
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q61553
ChainResidueDetails
ALYS74
BLYS74
CLYS74
DLYS74
ELYS74
FLYS74

site_idSWS_FT_FI4
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER127
ESER234
FSER127
FSER234
ASER234
BSER127
BSER234
CSER127
CSER234
DSER127
DSER234
ESER127

site_idSWS_FT_FI5
Number of Residues6
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ATHR239
BTHR239
CTHR239
DTHR239
ETHR239
FTHR239

site_idSWS_FT_FI6
Number of Residues6
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P85845
ChainResidueDetails
ATHR403
BTHR403
CTHR403
DTHR403
ETHR403
FTHR403

site_idSWS_FT_FI7
Number of Residues12
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447
ChainResidueDetails
ALYS399
FLYS399
BLYS399
CLYS399
DLYS399
ELYS399

224201

PDB entries from 2024-08-28

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